Therapeutic Drug Monitoring of Antimicrobial Drugs in Neonates: An Opinion Article

Autor: J N van den Anker, Daan J Touw

Publikováno v: Therapeutic Drug Monitoring, 44(1), 65-74. Lippincott Williams & Wilkins

BACKGROUND: Neonatal infections are associated with high morbidity and mortality rates. Optimal treatment of these infections requires knowledge of neonatal pharmacology and integration of neonatal developmental pharmacokinetics (PKs) of antimicrobia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf7b3da23306f112aef52495a5aa0b23
https://pure.eur.nl/en/publications/597d76cb-b031-4f5b-954e-d083df29a1c3

Challenges in conducting paediatric trials with off-patent drugs

Autor: J. N. van den Anker, Helle Holst, Inger Merete Jørgensen, Kim Dalhoff, Tine Brink Henriksen, Sissel Sundell Haslund-Krog, N.M. Debes

Publikováno v: Haslund-Krog, S S, Jorgensen, I M, Henriksen, T B, Dalhoff, K, Debes, N M, van den Anker, J & Holst, H 2021, ' Challenges in conducting paediatric trials with off-patent drugs ', Contemporary Clinical Trials Communications, vol. 23, 100783 . https://doi.org/10.1016/j.conctc.2021.100783
Contemporary Clinical Trials Communications
Contemporary Clinical Trials Communications, Vol 23, Iss, Pp 100783-(2021)

Introduction For more than two decades several initiatives have emerged to increase recruitment of paediatric patients in drug trials. While trials of newly approved drugs have successfully included paediatric patients in their drug development plan,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbec4ce3e7d3ef8bedce2dc0c7598d92
https://doi.org/10.1016/j.conctc.2021.100783

Sildenafil and Retinopathy of Prematurity Risk in Very Low Birth Weight Infants

Autor: Samira Samiee-Zafarghandy, Christoph P. Hornik, J N van den Anker, Reese H. Clark, M M Laughon, P B Smith

Publikováno v: Journal of perinatology : official journal of the California Perinatal Association
Journal of Perinatology, 36(2), 137-140. Nature Publishing Group

Objective To examine the effect of sildenafil therapy on development of severe retinopathy of prematurity (ROP) requiring surgical intervention in premature infants. Study Design We identified premature infants who were discharged from Pediatrix Medi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e945e9d7579d4e4856bc40b9154ed986
http://europepmc.org/articles/PMC4731250

Simultaneous determination of trimethoprim and sulfamethoxazole in dried plasma and urine spots

Autor: Gina A. Simone, Andrew Lewandowski, Katherine Y. Berezny, Amy Delinsky, Barrie Harper, Ian M. Paul, T. Bratton, Zhaoxia Ren, Edmund V. Capparelli, B. Poindexter, Andrew M. Atz, Kanecia O. Zimmerman, Kelly C. Wade, J. Sullivan, Thomas J. Walsh, Chiara Melloni, Alice Pagan, T. M. O'Shea, H. Al Nasiri, Daniel Gonzalez, A. Lewandowski, K. Tsilou, David A. Siegel, Gregory L. Kearns, Daniel K. Benjamin, Brenda B. Poindexter, L. Smiley, A. Muelenaer, P B Smith, L. Fern, Michael Cohen-Wolkowiez, Paula Delmore, Janice E. Sullivan, Ravinder Anand, J. N. van den Anker, Donna Cannonier, Anne Zajicek, Ram Yogev, Perdita Taylor-Zapata, R. Yogev, M M Laughon, Kenneth C. Lewis, Susan R. Mendley, B. Harper

Publikováno v: Bioanalysis. 7:1137-1149

Background: Trimethoprim-sulfamethoxazole (TMP-SMX) is an antimicrobial drug combination commonly prescribed in children and adults. The study objectives were to validate and apply an HPLC–MS/MS method to quantify TMP-SMX in dried plasma spots (DPS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00c3876b8334761b9e0b9141754396a
https://doi.org/10.4155/bio.15.38

Intestinal fatty-acid binding protein and metronidazole response in premature infants

Autor: P B Smith, Barry T. Bloom, Edmund V. Capparelli, Mario R. Sampson, Daniel K. Benjamin, Michael Cohen-Wolkowiez, J. N. van den Anker, Antonio Arrieta, G. L. Kearns

Publikováno v: Journal of Neonatal-Perinatal Medicine. 7:223-228

Fatty acid-binding proteins are small (14-15 kD) proteins that transport fatty acids in enterocytes. Human intestinal fatty acid-binding protein (I-FABP) is found in mature enterocytes of the small intestine [1]. This protein is rapidly released in b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::731fa28afac0a87e1e0cf1f812c73d64
https://doi.org/10.3233/npm-1477013