Výsledky vyhledávání - "J. N. Wright"

The impact of aromatase mechanism on other P450s

Autor: J. N. Wright, Peter Lee-Robichaud, M. E. Akhtar, M. Akhtar

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 61:127-132

Experimental findings from a number of laboratories have converged to show that the conversion of androgens into oestrogen, catalysed by aromatase, involves three distinct reactions which occur at a single active site. That each one of these reaction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4c3c56c0f999163e0aa38ca777f48cb
https://doi.org/10.1016/s0960-0760(97)80003-9

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Crystallization and preliminary X-ray diffraction analysis of calexcitin fromLoligo pealei: a neuronal protein implicated in learning and memory

Autor: R. Gill, Fiyaz Mohammed, J. Vernon, J. N. Wright, Peter T. Erskine, Jonathan B. Cooper, K. P. Giese, Steve P. Wood, G. D. E. Beaven

Publikováno v: Acta Crystallographica Section F Structural Biology and Crystallization Communications. 61:879-881

The neuronal protein calexcitin from the long-finned squid Loligo pealei has been expressed in Escherichia coli and purified to homogeneity. Calexcitin is a 22 kDa calcium-binding protein that becomes up-regulated in invertebrates following Pavlovian

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68dbec7c4ce3f5ab6ad5dfd787ed5e08
https://doi.org/10.1107/s1744309105026758

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A transition from ionic to free-radical mechanisms in chemistry and enzymology

Autor: P. Robichaud, A. Z. Shyadehi, Muhammad Akhtar, J. N. Wright

Publikováno v: Pure and Applied Chemistry. 66:2387-2390

Examples were presented of enzymes which catalyse different generic reactions at the same These enzymes which belong to the P-450 class are aromatase, 1401- active site. demethylase, 17a-hydroxylase-17,20-lyase and nitric oxide synthase. 2) The multi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62c35f408d9c7024f76c0d968e0a9ad0
https://doi.org/10.1351/pac199466102387

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Crystallization and preliminary X-ray diffraction analysis of the protease from Southampton norovirus complexed with a Michael acceptor inhibitor

Autor: Paul R. Lambden, Leighton Coates, R. J. Hussey, Steve P. Wood, Ian N. Clarke, P. T. Erskine, Jonathan B. Cooper, J. N. Wright, S. Coker, R. Broadbridge, Peter M. Shoolingin-Jordan, M. Sarwar, R. Gill

Noroviruses are the predominant cause of human epidemic nonbacterial gastroenteritis. Viral replication requires a cysteine protease that cleaves a 200 kDa viral polyprotein into its constituent functional parts. Here, the crystallization of the reco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c862cde6562c4ed741984900230ac75b
https://europepmc.org/articles/PMC3001671/

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Crystallization and preliminary X-ray diffraction analysis of L-threonine dehydrogenase (TDH) from the hyperthermophilic archaeon Thermococcus kodakaraensis

Autor: J. N. Wright, Muhammad Akhtar, Jonathan B. Cooper, Alun R. Coker, Peter T. Erskine, Naeem Rashid, Farrukh Jamil, A. Bowyer, Qamar Bashir, Halina Mikolajek

Publikováno v: Acta crystallographica. Section F, Structural biology and crystallization communications. 64(Pt 9)

The enzyme L-threonine dehydrogenase catalyses the NAD(+)-dependent conversion of L-threonine to 2-amino-3-ketobutyrate, which is the first reaction of a two-step biochemical pathway involved in the metabolism of threonine to glycine. Here, the cryst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b248ea0723b6d578786365367613ed55
https://pubmed.ncbi.nlm.nih.gov/18765916

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Interaction of human CYP17 (P-450(17alpha), 17alpha-hydroxylase-17,20-lyase) with cytochrome b5: importance of the orientation of the hydrophobic domain of cytochrome b5

Autor: Peter Lee-Robichaud, M A Kaderbhai, Naheed Kaderbhai, J. N. Wright, M. Akhtar

Publikováno v: The Biochemical journal. 321

Human CYP17 (P-45017α, 17α-hydroxylase-17,20-lyase)-catalysed side-chain cleavage of 17α-hydroxyprogestogens into androgens is greatly dependent on the presence of cytochrome b5. The native form of cytochrome b5 is composed of a globular core, res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94dc97712e108a1ad8f69c92e67ff415
https://pubmed.ncbi.nlm.nih.gov/9032476

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Mechanistic kinship between hydroxylation and desaturation reactions: acyl-carbon bond cleavage promoted by pig and human CYP17 (P-450(17)alpha; 17 alpha-hydroxylase-17,20-lyase)

Autor: Akbar Z. Shyadehi, J N Wright, M. E. Akhtar, Muhammad Akhtar, Peter Lee-Robichaud

Publikováno v: Biochemistry. 34(43)

Using homogeneous pig and recombinant human CYP17, the mechanism of the acyl-carbon bond fission involved in the direct cleavage of pregnenolone was studied. It was found that the formation of androsta-5,16-dien-3 beta-ol (5,16-diene) and androst-5-e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0411f3d9e612867f24cfb2b2212be02e
https://pubmed.ncbi.nlm.nih.gov/7578007

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Human factors in rural road crashes

Autor: A J McLean, J. M. Barker, G.A. Ryan, J. N. Wright

Publikováno v: Australian journal of public health. 16(3)

An in-depth study of 79 vehicle crashes on rural roads in an area of about 100 km radius around Adelaide examined sociodemographic and psychophysiological characteristics of the drivers and riders involved. In many respects this sample of crashes was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04fb4c0e7536cbf85bb73ee989c6da40
https://pubmed.ncbi.nlm.nih.gov/1482719

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