Zobrazeno 1 - 10
of 16
pro vyhledávání: '"J. N. T. Gilbert"'
Publikováno v:
Journal of Pharmacy and Pharmacology. 27:923-927
The urinary excretion of secbutobarbitone (I) and its metabolites has been studied quantitatively using combined gas chromatographymass spectrometry. After a single oral dose was given to healthy male volunteers, unchanged drug (5–9%), 2′-hydroxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304d46daaecafcd92694f243b566f713
https://doi.org/10.1111/j.2042-7158.1975.tb10249.x
https://doi.org/10.1111/j.2042-7158.1975.tb10249.x
Publikováno v:
Journal of Pharmacy and Pharmacology. 26:119-122
The human metabolism of 5-allyl-5-neopentylbarbituric acid (nealbarbitone, Censedal), taken orally, has been studied. Comparison of the gas chromatography—mass spectra of extracts from urine with the spectra of model compounds showed nealbarbitone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d7273081e361553063771a8e9111292
https://doi.org/10.1111/j.2042-7158.1974.tb09236.x
https://doi.org/10.1111/j.2042-7158.1974.tb09236.x
Publikováno v:
Journal of Pharmacy and Pharmacology. 26:16P-23P
Experimentally determined concentrations of butobarbitone, and three or its metabolites, in the urine of two volunteers, have been studied using a computer technique, which tests the data for limited capacity or first order kinetics. In both voluntee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23883a9fe251bf1c935ba1ebbdaca8e6
https://doi.org/10.1111/j.2042-7158.1974.tb10072.x
https://doi.org/10.1111/j.2042-7158.1974.tb10072.x
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 5:75-80
The metabolism of pentobarbitone has been investigated in two healthy volunteers, and the urinary excretion of unchanged drug, and the products of omega- and (omega-1)-oxidation, quantified for four days after each of three doses to each volunteer. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aa047114fd82f9ee2da7eabeb2b5db7
https://doi.org/10.1007/bf03189449
https://doi.org/10.1007/bf03189449
Publikováno v:
Journal of Pharmacy and Pharmacology. 30:220-232
The proportions of the main components present in gentamicin sulphate complex, gentamicins C1, C1a and C2, can be monitored by 1H nuclear magnetic resonance (nmr) spectrometry. The method depends on measurement of the peak heights of signals for N-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d981e841251ce21038a72bbfcfbc358b
https://doi.org/10.1111/j.2042-7158.1978.tb13208.x
https://doi.org/10.1111/j.2042-7158.1978.tb13208.x
Autor:
Brian J. Millard, J. N. T. Gilbert
Publikováno v:
Organic Mass Spectrometry. 2:17-31
The mass spectra of twenty-six commercially available medicinal phenothiazines have been determined at high resolution. In each compound, the side chain attached to the 10-position of the phenothiazine ring contains nitrogen and fission of the CC bon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36efcc1715bdc05c128ffebd3ade4be8
https://doi.org/10.1002/oms.1210020103
https://doi.org/10.1002/oms.1210020103
Publikováno v:
Journal of Pharmacy and Pharmacology. 26:123-125
The human metabolism of 5-ethyl-5-cycloheptenylbarbituric acid, heptabarbitone, Medomin, taken orally, has been studied. Comparison of g.c., and g.c.-m.s. data, from derivatized urine extracts, with data from authentic synthetic samples, has shown th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aadf3a8f7fe2691182b22c305062c6b
https://doi.org/10.1111/j.2042-7158.1974.tb09237.x
https://doi.org/10.1111/j.2042-7158.1974.tb09237.x
Autor:
J. N. T. Gilbert, J. W. Powell
Publikováno v:
Biomedical mass spectrometry. 1(2)
The urinary excretion of butobarbitone and its metabolites has been studied quantitatively using combined gas chromatography-mass fragmentography, tuned to ions at m/e 169 and 184. After a single oral dose (200 mg) to healthy male volunteers, unchang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a3a3d0e8cd92159f356c67f79d570e
https://pubmed.ncbi.nlm.nih.gov/4433727
https://pubmed.ncbi.nlm.nih.gov/4433727
Publikováno v:
The Journal of pharmacy and pharmacology. 27(5)
The human metabolism of (±)-5-allyl-5-(1′-methylbutyl) barbituric acid (I), quinalbarbitone, taken orally, has been studied. Comparison of g.c. and g.c.-m.s. data from derivatized extracts of urine with similar data from synthetic samples confirme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e911444803529e77ff034dded5cae8c9
https://pubmed.ncbi.nlm.nih.gov/239135
https://pubmed.ncbi.nlm.nih.gov/239135
Publikováno v:
The Journal of pharmacy and pharmacology. 30(3)
N-Hydroxyaprobarbitone (I) has been synthesized by oxidation of aprobarbitone, characterized, and a method developed for its estimation in urine. It has shown to be no more than a minor metabolite (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::349ee0fe910db47d8b6255d69c4f8909
https://pubmed.ncbi.nlm.nih.gov/24691
https://pubmed.ncbi.nlm.nih.gov/24691