Výsledky vyhledávání - "J. N. McDougal"

Determination of Skin:Air Partition Coefficients for Volatile Chemicals: Experimental Method and Applications

Autor: J. N. Mcdougal, G W Jepson, G D Bates, D. R. Mattie, Jeffrey W. Fisher

Publikováno v: Fundamental and Applied Toxicology. 22:51-57

Determination of Skin:Air Partition Coefficients for Volatile Chemicals: Experimental Method and Applications. Mattie, D. R., Bates, Jr., G. D., Jepson, G. W., Fisher, J. W., and McDougal, J. N. (1994). Fundam. Appl. Toxicol. 22, 51-57. The partition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39134bd0a36f0a3744b760b756c739c6
https://doi.org/10.1006/faat.1994.1007

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Comparative Study of Molecular Mechanisms of Skin Irritation After Acute Exposure to m-XYLENE in Rats and Guinea Pigs

Autor: C. M. Garrett, J. V. Rogers, W. W. Brinkely, J. N. McDougal, P. G. Gunasekar, M. B. Kabbur

Organic solvents like xylene are recognized as skin irritants after dermal exposure. The molecular responses to organic solvents that result in acute irritation are not understood. In the present study, we compared and quantified the molecular respon

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https://doi.org/10.21236/ada453214

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Effects of JP-8 on Molecular and Histological Parameters Related to Acute Skin Irritation

Autor: J. N. McDougal, W. W. Brinkley, C. M. Garrett, M. B. Kabbur, P. G. Gunasekar, K. T. Geiss, J. V. Rogers

Organic chemicals such as jet fuels and solvents are recognized to cause skin irritation after dermal exposure. The molecular responses to these chemicals that result in acute irritation are not understood well enough to allow the establishment and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a4610cee86ad577d0c5a4e926cf947e
https://doi.org/10.21236/ada453179

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Inflammatory damage to skin by prolonged contact with 1,2-dichlorobenzene and chloropentafluorobenzene

Autor: J N, McDougal, J H, Grabau, L, Dong, D R, Mattie, G W, Jepson

Publikováno v: Microscopy research and technique. 37(3)

Skin samples from Fischer-344 rats and Hartley guinea pigs exposed dermally to 1,2-dichlorobenzene (DCB) and chloropentafluorobenzene (CPFB) for up to 4 h were examined for chemical-induced damage. Samples were stained with hematoxylin and eosin and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::75dd72536d1e94a511f925d722a051d3
https://pubmed.ncbi.nlm.nih.gov/9144633

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Rat to human extrapolation of HCFC-123 kinetics deduced from halothane kinetics: a corollary approach to physiologically based pharmacokinetic modeling

Autor: J. N. Mcdougal, Jeffrey W. Fisher, Annie M. Jarabek, R. J. Williams, Allen Vinegar

Publikováno v: Fundamental and applied toxicology : official journal of the Society of Toxicology. 30(1)

The goal of this study was to develop a human physiologically based pharmacokinetic (PBPK) model for the chemical HCFC-123 (2,2-dichloro-1,1,1-trifluoroethane) and its major metabolite, trifluoroacetic acid (TFA). No human kinetic data for HCFC-123 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f875c5ded3e1b134714e663a48582f72
https://pubmed.ncbi.nlm.nih.gov/8812223

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Multilayered dermal subcompartments for modeling chemical absorption

Autor: D. W. Quinn, J. N. McDougal, C. R. McDaniel, R. L. Bookout

Publikováno v: SAR and QSAR in environmental research. 5(3)

Dermal penetration of chemicals and drugs is of concern to both toxicologists and pharmacologists. Environmental professionals try to limit exposure to chemicals using protective clothing and gloves or barrier creams to trap chemicals. Drug developer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3370adc719cdb29d3a2caeaf36f3c287
https://pubmed.ncbi.nlm.nih.gov/9114511

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Kinetics of water vapor sorption in porcine stratum corneum

Autor: Z, Liron, H J, Clewell, J N, McDougal

Publikováno v: Journal of pharmaceutical sciences. 83(5)

The kinetics of water vapor absorption-desorption was studied in the porcine stratum corneum (sc) at 25 degrees C. Dry sc samples were exposed to several relative humidities followed by exposure to dry air, and the change in weight was monitored over

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https://pubmed.ncbi.nlm.nih.gov/8071823

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Dermal absorption of organic chemical vapors in rats and humans

Autor: J N, McDougal, G W, Jepson, H J, Clewell, M L, Gargas, M E, Andersen

Publikováno v: Fundamental and applied toxicology : official journal of the Society of Toxicology. 14(2)

Quantitation of chemical vapor penetration through skin is necessary for assessment of health hazards involved in some occupational environments. Information on penetration of vapors through human skin is minimal because human exposures are not sanct

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https://pubmed.ncbi.nlm.nih.gov/2318354

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Autor: Thomas F. Burks, M. S. Miller, D. L. Kreulen, J. N. McDougal

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 247:G542-G546

Aging in humans is associated with changes in gastrointestinal function. We wanted to determine whether a similar phenomenon occurs in rats and whether rats would be a suitable model to study changes in the gastrointestinal tract with age. Intestinal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f57e69d417c580fee3a01c03c311070
https://doi.org/10.1152/ajpgi.1984.247.5.g542

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