Výsledky vyhledávání

Current status of adjuvant endocrine therapy for breast cancer

Autor: J N, Ingle

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7

Adjuvant endocrine therapy is a vitally important modality for treatment of women with resected hormone-sensitive breast cancer as indicated by the presence of estrogen and/or progesterone receptors in the tumor. It is not recommended in those patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8523cf09525f9fc363d42a700d7fdbf5
https://pubmed.ncbi.nlm.nih.gov/11916230

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Structural analysis of the 17q22-23 amplicon identifies several independent targets of amplification in breast cancer cell lines and tumors

Autor: G, Wu, C, Sinclair, S, Hinson, J N, Ingle, P C, Roche, F J, Couch

Publikováno v: Cancer research. 61(13)

A novel region of amplification in breast tumors has recently been identified on chromosome 17q22-23. In an effort to identify the oncogenes in the region that are targeted by the amplification process, we determined the structure of the amplicon in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::65a8dbd6dc9d564347449d85c37d45b3
https://pubmed.ncbi.nlm.nih.gov/11431322

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Aromatase inhibition and antiestrogen therapy in early breast cancer treatment and chemoprevention

Autor: J N, Ingle

Publikováno v: Oncology (Williston Park, N.Y.). 15(5 Suppl 7)

The aromatase inhibitors represent an important class of hormonal agents for the management of breast cancer. The third-generation aromatase inhibitors have replaced megestrol acetate as second-line hormonal therapy in advanced breast cancer, and lar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::23b85aff2ff07f0ba0de34becf1e0af7
https://pubmed.ncbi.nlm.nih.gov/11396362

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Bisphosphonates directly regulate cell proliferation, differentiation, and gene expression in human osteoblasts

Autor: G G, Reinholz, B, Getz, L, Pederson, E S, Sanders, M, Subramaniam, J N, Ingle, T C, Spelsberg

Publikováno v: Cancer research. 60(21)

Bisphosphonates are widely used clinically to treat bone diseases in which bone resorption is in excess. However, the mechanism of bisphosphonate action on bone is not fully understood. Studies of direct action of bisphosphonates on bone have been li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::039bd783e2515dd3c0032fe8f4408182
https://pubmed.ncbi.nlm.nih.gov/11085520

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17q23 amplifications in breast cancer involve the PAT1, RAD51C, PS6K, and SIGma1B genes

Autor: G J, Wu, C S, Sinclair, J, Paape, J N, Ingle, P C, Roche, C D, James, F J, Couch

Publikováno v: Cancer research. 60(19)

Amplification of the 17q23 region occurs frequently in breast tumors. To characterize the structure of 17q23 amplicons and to identify oncogene targets associated with this alteration, we performed a copy number analysis of 87 17q23 localized express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::23c2011551b02637782c12f6626def63
https://pubmed.ncbi.nlm.nih.gov/11034073

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External radiation exposure and mortality in a cohort of uranium processing workers

Autor: J. Watkins, J. N. Ingle, J. Phillips, E. Dupree-Ellis

Publikováno v: American journal of epidemiology. 152(1)

In a study of 2,514 White male workers employed between 1942 and 1966 at a US uranium processing plant, mortality was compared with overall US mortality, and the relation between external ionizing radiation and cancer was evaluated. Through 1993, 1,0

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272eb2d05682b30ec2c778f4509b6c34
https://pubmed.ncbi.nlm.nih.gov/10901334

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