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The highly lipophilic DNA topoisomerase I inhibitor DB-67 displays elevated lactone levels in human blood and potent anticancer activity

Autor: David Bom, Thomas G. Burke, Robert L. Bevins, J. N. Howe, Stefan Kruszewski, Lori J. Latus, Stephen G. Zimmer, AL Bingcang, Junhong Zhang, Dennis P. Curran

Publikováno v: Journal of Controlled Release. 74:325-333

The novel silatecan 7-t-butyldimethylsilyl-10-hydroxycamptothecin (DB-67) is 25- to 50-times more lipophilic than camptothecin and readily incorporates into lipid bilayers. Using the method of fluorescence anisotropy titration, we determined that DB-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d818169135afd043418c7f4b0b2a25c5
https://doi.org/10.1016/s0168-3659(01)00343-1

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Sensitivity of ocean circulation to warming during the Early Eocene greenhouse.

Autor: Turner, Sandra Kirtland, Ridgwell, Andy, Keller, Allison L., Vahlenkamp, Maximilian, Aleksinski, Adam K., Sexton, Philip F., Penman, Donald E., Hull, Pincelli M., Norris, Richard D.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America; 6/11/2024, Vol. 121 Issue 24, p1-8, 19p

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Geometry of the Meridional Overturning Circulation at the Last Glacial Maximum.

Autor: PAVIA, FRANK J.¹ fjpavia@caltech.edu, JONES, C. SPENCER^2,3, HINES, SOPHIA K.⁴

Publikováno v: Journal of Climate. Sep2022, Vol. 35 Issue 17, p5465-5482. 18p.

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Acoustic travel-time variability observed on a 150-km radius tomographic array in the Canada Basin during 2016–2017.

Autor: Worcester, Peter F., Dzieciuch, Matthew A., Vazquez, Heriberto J., Cornuelle, Bruce D., Colosi, John A., Krishfield, Richard A., Kemp, John N.

Publikováno v: Journal of the Acoustical Society of America; May2023, Vol. 153 Issue 5, p2621-2636, 16p

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Localization of a remote source in a noisy deep ocean sound channel using phase-only matched autoproduct processinga).

Autor: Geroski, David J., Johnson, Jay R., Dowling, David R.

Publikováno v: Journal of the Acoustical Society of America; Apr2023, Vol. 153 Issue 4, p2223-2237, 15p

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Deep-water first occurrences of Ediacara biota prior to the Shuram carbon isotope excursion in the Wernecke Mountains, Yukon, Canada.

Autor: Boag TH; Department of Earth and Planetary Science, Stanford University, Stanford, California, USA.; Department of Earth and Planetary Sciences, Yale University, New Haven, Connecticut, USA.; Department of Geosciences, Princeton University, Princeton, New Jersey, USA., Busch JF; Department of Earth Sciences, Dartmouth College, Hanover, New Hampshire, USA., Gooley JT; Alaska Science Center, U.S. Geological Survey, Anchorage, Alaska, USA., Strauss JV; Department of Earth Sciences, Dartmouth College, Hanover, New Hampshire, USA., Sperling EA; Department of Earth and Planetary Science, Stanford University, Stanford, California, USA.

Publikováno v: Geobiology [Geobiology] 2024 May-Jun; Vol. 22 (3), pp. e12597.

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