Zobrazeno 1 - 10
of 20
pro vyhledávání: '"J. N. Glover"'
Publikováno v:
Applied and Environmental Microbiology. 89
Oxygen-evolving photosynthetic cyanobacteria evolved ~3 billion years ago, performing fundamental roles in the biogeochemical evolution of the early Earth and continue to perform fundamental roles in nutrient cycling and primary productivity today. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24bc79bb1156475db718104d6d08f00f
https://doi.org/10.1128/aem.00015-23
https://doi.org/10.1128/aem.00015-23
Autor:
D McDonald, J. N. Glover, Msy Pulvino, J Zhao, Craig J. Markin, Curtis D. Hodge, Michael J. Hendzel, Msy Huen, Leo Spyracopoulos, Ross A. Edwards
Publikováno v:
ACS Chemical Biology. 10:1718-1728
Ubc13 is an E2 ubiquitin conjugating enzyme that functions in nuclear DNA damage signaling and cytoplasmic NF-κB signaling. Here, we present the structures of complexes of Ubc13 with two inhibitors, NSC697923 and BAY 11-7082, which inhibit DNA damag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f85a9cfd0cb1ef77984bd394ba3376
https://doi.org/10.1021/acschembio.5b00222
https://doi.org/10.1021/acschembio.5b00222
Publikováno v:
Proceedings of the National Academy of Sciences. 108:21022-21027
Polynucleotide kinase/phosphatase (PNKP) is a critical mammalian DNA repair enzyme that generates 5′-phosphate and 3′-hydroxyl groups at damaged DNA termini that are required for subsequent processing by DNA ligases and polymerases. The PNKP phos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a4d600b9fddd287b1c16ad5ca815a8
https://doi.org/10.1073/pnas.1112036108
https://doi.org/10.1073/pnas.1112036108
Publikováno v:
Biochemistry
The BRCA1 BRCT domain binds pSer-x-x-Phe motifs in partner proteins to regulate the cellular response to DNA damage. Approximately 120 distinct missense variants have been identified in the BRCA1 BRCT through breast cancer screening, and several of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d560233e4eac582f184100093950fe
https://doi.org/10.1021/bi2003795
https://doi.org/10.1021/bi2003795
Autor:
D.C Williams, E.R White, David E. Hacker, Ross A. Edwards, Jason M. Beckta, Luxin Sun, Kristoffer Valerie, B.A Danzig, Z Ma, Matthew C. T. Hartman, M Huie, J. N. Glover
Publikováno v:
ACS chemical biology. 10(5)
Many intracellular protein-protein interactions are mediated by the phosphorylation of serine, and phosphoserine-containing peptides can inhibit these interactions. However, hydrolysis of the phosphate by phosphatases, and the poor cell permeability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d50978042503446bf3dd750315c04ad
https://pubmed.ncbi.nlm.nih.gov/25654734
https://pubmed.ncbi.nlm.nih.gov/25654734
Autor:
Craig J. Markin, J. N. Glover, Wei Xiao, Manoj Kumar Rout, Curtis D. Hodge, Leo Spyracopoulos, Xin Xu
Publikováno v:
Journal of the American Chemical Society. 136(50)
Initiation of the DNA damage and innate immune responses is dependent upon the flow of chemical information through coupled protein-protein interaction networks and driven by the synthesis and recognition of Lys 63 linked polyubiquitin (polyUb) chain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3eef0151a1f02d7ce9320420ec726bb
https://pubmed.ncbi.nlm.nih.gov/25423605
https://pubmed.ncbi.nlm.nih.gov/25423605
Publikováno v:
Nature Structural Biology. 8:838-842
The C-terminal BRCT region of BRCA1 is essential for its DNA repair, transcriptional regulation and tumor suppressor functions. Here we determine the crystal structure of the BRCT domain of human BRCA1 at 2.5 A resolution. The domain contains two BRC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34b47f0690d2ac7399f01290a1f22903
https://doi.org/10.1038/nsb1001-838
https://doi.org/10.1038/nsb1001-838
Autor:
Trevor F. Moraes, Michael J. Ellison, Sean A. McKenna, Wei Xiao, Landon Pastushok, J. N. Glover, R.A. Edwards
Publikováno v:
Nature Structural Biology. 8:669-673
The ubiquitin conjugating enzyme complex Mms2-Ubc13 plays a key role in post-replicative DNA repair in yeast and the NF-kappaB signal transduction pathway in humans. This complex assembles novel polyubiquitin chains onto yet uncharacterized protein t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96e045d45144f1b0ae5613540c6479d5
https://doi.org/10.1038/90373
https://doi.org/10.1038/90373
Publikováno v:
Nature Structural Biology. 7:565-569
The conjugative transfer of F-like plasmids is repressed by FinO, an RNA binding protein. FinO interacts with the F-plasmid encoded traJ mRNA and its antisense RNA, FinP, stabilizing FinP against endonucleolytic degradation and facilitating sense–a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf23a938aec1fb9d316fec9de6b2f48c
https://doi.org/10.1038/76790
https://doi.org/10.1038/76790
Autor:
J. N. Glover
Publikováno v:
Physical Review A. 42:7050-7056
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5605a99cfa484ef0dd8cc7fa699b3b6
https://doi.org/10.1103/physreva.42.7050
https://doi.org/10.1103/physreva.42.7050