Zobrazeno 1 - 7
of 7
pro vyhledávání: '"J. N. Earnhardt"'
Autor:
J. N. Earnhardt, Philip J. Laipis, David N. Silverman, Chingkuang Tu, S. K. Wright, Ronald E. Viola, Minzhang Qian
Publikováno v:
Archives of Biochemistry and Biophysics. 361:264-270
The rate-limiting step in the catalysis of the hydration of CO2 by carbonic anhydrase involves transfer of protons between zinc-bound water and solution. This proton transfer can be enhanced by proton shuttle residues within the active-site cavity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad650f9c8a13a25f09ae560663451d1b
https://doi.org/10.1006/abbi.1998.0984
https://doi.org/10.1006/abbi.1998.0984
Publikováno v:
Journal of neurotrauma. 19(9)
Free radical-mediated mechanisms of cellular damage have been implicated in the early stages of spinal cord injury (SCI). Manganese superoxide dismutase (MnSOD) is a potent scavenger of superoxide radicals and likely serves an important cytoprotectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed3a20a76c9554597f83b0db0b67a676
https://pubmed.ncbi.nlm.nih.gov/12482119
https://pubmed.ncbi.nlm.nih.gov/12482119
Autor:
A. V. C. Tabernilla, F. Evelyn, M. Dobrzeniecka, Douglas K. Anderson, L. William, B. McCray, J. N. Earnhardt, Harry S. Nick, B. E. Keeler
Publikováno v:
Journal of Neurochemistry. 81:106-107
A unique gene expression pattern/transcriptome characterizes the presentation of every disease state. Strategies for identification of gene families with altered expression patterns offer an information rich approach to initially assess the relevance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7100bdb6291511ed679d7f04f48bfb35
https://doi.org/10.1046/j.1471-4159.81.s1.41_2.x
https://doi.org/10.1046/j.1471-4159.81.s1.41_2.x
Publikováno v:
Journal of Neurochemistry. 81:106-107
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5deefb30cf774fe718e4cd784478ffc
https://doi.org/10.1046/j.1471-4159.81.s1.41_1.x
https://doi.org/10.1046/j.1471-4159.81.s1.41_1.x
Autor:
Nils Bergenhem, J. N. Earnhardt, David N. Silverman, Chingkuang Tu, Maha M. Lakkis, Richard E. Tashian, P. J. Laipis, Minzhang Qian
Publikováno v:
Biochemistry. 37(30)
Carbonic anhydrase VII (CA VII) appears to be the most highly conserved of the active mammalian carbonic anhydrases. We have characterized the catalytic activity and inhibition properties of a recombinant murine CA VII. CA VII has steady-state consta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::195fbc83eddb0c28fd94077a8090dce6
https://pubmed.ncbi.nlm.nih.gov/9692974
https://pubmed.ncbi.nlm.nih.gov/9692974
Publikováno v:
Biochemistry. 37(20)
The hydration of CO2 catalyzed by carbonic anhydrase requires proton transfer from the zinc-bound water at the active site to solution for each cycle of catalysis. In the most efficient of the mammalian carbonic anhydrases, isozyme II, this transfer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48fa72d1466b64a08f7dc719b6d1b6ad
https://pubmed.ncbi.nlm.nih.gov/9585580
https://pubmed.ncbi.nlm.nih.gov/9585580
We investigated the efficiency of glutamic acid 64 and aspartic acid 64 as proton donors to the zinc-bound hydroxide in a series of site-specific mutants of human carbonic anhydrase III (HCA III). Rate constants for this intramolecular proton transfe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::105238e616cb0c4c2da792ebd5fc971a
https://europepmc.org/articles/PMC1299658/
https://europepmc.org/articles/PMC1299658/
