Zobrazeno 1 - 10 of 14 pro vyhledávání: '"J. N. Cogburn"'
1
Diarylspiro[2.4]heptenes as Orally Active, Highly Selective Cyclooxygenase-2 Inhibitors: Synthesis and Structure−Activity Relationships
Autor: Gary D. Anderson, A. W. Veenhuizen, Carol M. Koboldt, Karen Seibert, Robert E. Manning, William E. Perkins, Yan Zhang, Horng-Chi Huang, J. N. Cogburn, D. J. Garland, Jinglin Li, Emily J. Reinhard, David B. Reitz, S. A. Gregory, Timothy S. Chamberlain, E. G. Burton, Peter C. Isakson
Publikováno v: Journal of Medicinal Chemistry. 39:253-266
A novel series of 5,6-diarylspiro[2.4]hept-5-enes was shown to provide highly potent and selective cyclooxygenase-2 (COX-2) inhibitors. A study of structure-activity relationships in this series suggests that 3,4-disubstituted phenyl analogs are gene
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c9ef2e75bc7cbe29bd4ca9744f026f5
https://doi.org/10.1021/jm950664x
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2
1,2-Diarylcyclopentenes as Selective Cyclooxygenase-2 Inhibitors and Orally Active Anti-inflammatory Agents
Autor: G. D. Anderson, Peter C. Isakson, James J. Li, E. G. Burton, Danny J. Garland, H.‐C. Huang, Collins Jt, J. N. Cogburn, Carol M. Koboldt, Gregory Susan A
Publikováno v: Journal of Medicinal Chemistry. 38:4570-4578
A series of 1,2-diarylcyclopentene methyl sulfones and sulfonamides have been shown to be remarkably potent and selective cyclooxygenase-2 (COX-2) inhibitors. The methyl sulfone analogs 7 showed excellent COX-2 activity, with IC50s ranging from 0.003
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f18a210e0c7d6b883fb8e7bd82e3394
https://doi.org/10.1021/jm00022a023
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5
[Untitled]
Autor: Matthew G. Donovan, J. N. Cogburn, Charles Steven Schasteen
Publikováno v: Pharmaceutical Research. :210-216
The Caco-2 cell culture model of human small intestinal absorptive cells was used to investigate transepithelial transport. Transport of permeability markers such as mannitol demonstrated that Caco-2 monolayers became less permeable with increasing a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1375cf24f59b9507baf8c4917ebbb15e
https://doi.org/10.1023/a:1015844104539
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6
Selective cyclooxygenase-2 inhibitors: heteroaryl modified 1,2-diarylimidazoles are potent, orally active antiinflammatory agents
Autor: Rita M. Huff, Yan Zhang, A. W. Veenhuizen, Jing Yuan, Karen Seibert, D.-C. Yang, Xiangdong Xu, C. M. Koboldt, P. W. Collins, Yi Yu, Richard Weier, J. N. Cogburn, Koszyk Francis, J. Masferrer, W. E. Perkins, Ish Kumar Khanna, Peter C. Isakson
Publikováno v: Journal of medicinal chemistry. 43(16)
A series of heteroaryl modified 1,2-diarylimidazoles has been synthesized and found to be potent and highly selective (1000-9000-fold) inhibitors of the human COX-2. 3-Pyridyl derived COX-2 selective inhibitor (25) exhibited excellent activity in acu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bfe34e90df25defe00df2c8d29d4cea
https://pubmed.ncbi.nlm.nih.gov/10956225
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7
Pharmacokinetics, tissue distribution, metabolism, and excretion of celecoxib in rats
Autor: S K, Paulson, J Y, Zhang, A P, Breau, J D, Hribar, N W, Liu, S M, Jessen, Y M, Lawal, J N, Cogburn, C J, Gresk, C S, Markos, T J, Maziasz, G L, Schoenhard, E G, Burton
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 28(5)
The pharmacokinetics, tissue distribution, metabolism, and excretion of celecoxib, 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide, a cyclooxygenase-2 inhibitor, were investigated in rats. Celecoxib was metabolized exten
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0829865b01cd91a88c07e223de34fa19
https://pubmed.ncbi.nlm.nih.gov/10772629
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9
Sulphation of proteochondroitin and 4-methylumbelliferyl beta-D-xyloside-chondroitin formed by mouse mastocytoma cells cultured in sulphate-deficient medium
Autor: Jeremiah E. Silbert, Geetha Sugumaran, J. N. Cogburn
Publikováno v: The Biochemical journal. 296
Mouse mastocytoma cells were cultured in medium containing [3H]GlcN and concentrations of [35S]sulphate varying from 0.01 to 0.5 mM. Intracellular [35S]sulphate incorporation increased severalfold from the lowest concentrations, reaching a maximum at
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf691e609831c333fcaedd683e63591
https://pubmed.ncbi.nlm.nih.gov/8250831
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10
A model of human small intestinal absorptive cells. 1. Transport barrier
Autor: J N, Cogburn, M G, Donovan, C S, Schasteen
Publikováno v: Pharmaceutical research. 8(2)
The Caco-2 cell culture model of human small intestinal absorptive cells was used to investigate transepithelial transport. Transport of permeability markers such as mannitol demonstrated that Caco-2 monolayers became less permeable with increasing a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0e2e7eb39f9ea212e0bdc4408a405c7a
https://pubmed.ncbi.nlm.nih.gov/2023869
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