Neuropsychiatric symptoms in at-risk groups for AD dementia and their association with worry and AD biomarkers—results from the DELCODE study

Autor: Lena Sannemann, Ann-Katrin Schild, Slawek Altenstein, Claudia Bartels, Frederic Brosseron, Katharina Buerger, Nicoleta Carmen Cosma, Klaus Fliessbach, Silka Dawn Freiesleben, Wenzel Glanz, Michael T. Heneka, Daniel Janowitz, Ingo Kilimann, Xenia Kobeleva, Christoph Laske, Coraline D. Metzger, Matthias H. J. Munk, Robert Perneczky, Oliver Peters, Alexandra Polcher, Josef Priller, Boris Rauchmann, Christina Rösch, Janna Rudolph, Anja Schneider, Annika Spottke, Eike Jakob Spruth, Stefan Teipel, Ruth Vukovich, Michael Wagner, Jens Wiltfang, Steffen Wolfsgruber, Emrah Duezel, Frank Jessen, for the DELCODE Study Group

Publikováno v: Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-11 (2020)

Abstract Background Early identification of individuals at risk of dementia is mandatory to implement prevention strategies and design clinical trials that target early disease stages. Subjective cognitive decline (SCD) and neuropsychiatric symptoms

Externí odkaz: https://doaj.org/article/71cc6c5f10bf4e1c92842f37cb1987af

Cortical thickness of the posterior cingulate cortex is associated with the ketamine-induced altered sense of self: An ultra-high field MRI study

Autor: Lena Vera Danyeli, Zumrut Duygu Sen, Lejla Colic, Nils Opel, Alexander Refisch, Nikolai Blekic, Tamar Macharadze, Moritz Kretzschmar, Matthias H. J. Munk, Christian Gaser, Oliver Speck, Martin Walter, Meng Li

Subanesthetic doses of ketamine induce an antidepressant effect within hours in individuals with treatment-resistant depression while it furthermore induces immediate but transient psychotomimetic effects. Among these psychotomimetic effects, an alte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad5b500312ef4114ef57bf1c77cfea25
https://doi.org/10.31234/osf.io/rc3zd

Correction: Association of the delayed changes in glutamate levels and functional connectivity with the immediate network effects of S-ketamine

Autor: Lena Vera Danyeli, Zümrüt Duygu Sen, Lejla Colic, Lisa Kurzweil, Sabrina Gensberger-Reigl, Tamar Macharadze, Florian Götting, Alexander Refisch, Thomas Liebe, Tara Chand, Moritz Kretzschmar, Gerd Wagner, Nils Opel, Fabrice Jollant, Oliver Speck, Matthias H. J. Munk, Meng Li, Martin Walter

Publikováno v: Translational Psychiatry

Ketamine shows rapid antidepressant effects peaking 24 h after administration. The antidepressant effects may occur through changes in glutamatergic metabolite levels and resting-state functional connectivity (rsFC) within the default mode network (D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18f2a5e8e73b49f46bfd33b38f78281
https://hdl.handle.net/21.11116/0000-000C-B1D3-D

Neural correlates of attentional control in social anxiety disorder: the impact of early-life adversity and DNA methylation

Autor: Ariane Wiegand, Matthias H. J. Munk, Sanja Drohm, Andreas J. Fallgatter, Julia L. MacIsaac, Michael S. Kobor, Vanessa Nieratschker, Benjamin Kreifelts

Publikováno v: Journal of Psychiatry & Neuroscience : JPN

Background: Social anxiety disorder is characterized by intense fear and avoidance of social interactions and scrutiny by others. Although alterations in attentional control seem to play a central role in the psychopathology of social anxiety disorde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec383d5da3bb41a1b988c4a4d18d5f4e
https://doi.org/10.1503/jpn.210064

Midlife occupational cognitive requirements protect cognitive function in old age by increasing cognitive reserve

Autor: Luca Kleineidam, Steffen Wolfsgruber, Anne-Sophie Weyrauch, Linn E. Zulka, Simon Forstmeier, Sandra Roeske, Hendrik van den Bussche, Hanna Kaduszkiewicz, Birgitt Wiese, Siegfried Weyerer, Jochen Werle, Angela Fuchs, Michael Pentzek, Christian Brettschneider, Hans-Helmut König, Dagmar Weeg, Horst Bickel, Melanie Luppa, Francisca S. Rodriguez, Silka Dawn Freiesleben, Selin Erdogan, Chantal Unterfeld, Oliver Peters, Eike J. Spruth, Slawek Altenstein, Andrea Lohse, Josef Priller, Klaus Fliessbach, Xenia Kobeleva, Anja Schneider, Claudia Bartels, Björn H. Schott, Jens Wiltfang, Franziska Maier, Wenzel Glanz, Enise I. Incesoy, Michaela Butryn, Emrah Düzel, Katharina Buerger, Daniel Janowitz, Michael Ewers, Boris-Stephan Rauchmann, Robert Perneczky, Ingo Kilimann, Doreen Görß, Stefan Teipel, Christoph Laske, Matthias H. J. Munk, Annika Spottke, Nina Roy, Frederic Brosseron, Michael T. Heneka, Alfredo Ramirez, Renat Yakupov, Martin Scherer, Wolfgang Maier, Frank Jessen, Steffi G. Riedel-Heller, Michael Wagner

Publikováno v: Kleineidam, L, Wolfsgruber, S, Weyrauch, A-S, Zulka, L E, Forstmeier, S, Roeske, S, van den Bussche, H, Kaduszkiewicz, H, Wiese, B, Weyerer, S, Werle, J, Fuchs, A, Pentzek, M, Brettschneider, C, König, H-H, Weeg, D, Bickel, H, Luppa, M, Rodriguez, F S, Freiesleben, S D, Erdogan, S, Unterfeld, C, Peters, O, Spruth, E J, Altenstein, S, Lohse, A, Priller, J, Fliessbach, K, Kobeleva, X, Schneider, A, Bartels, C, Schott, B H, Wiltfang, J, Maier, F, Glanz, W, Incesoy, E I, Butryn, M, Düzel, E, Buerger, K, Janowitz, D, Ewers, M, Rauchmann, B-S, Perneczky, R, Kilimann, I, Görß, D, Teipel, S, Laske, C, Munk, M H J, Spottke, A, Roy, N, Brosseron, F, Heneka, M T, Ramirez, A, Yakupov, R, Scherer, M, Maier, W, Jessen, F, Riedel-Heller, S G & Wagner, M 2022, ' Midlife occupational cognitive requirements protect cognitive function in old age by increasing cognitive reserve ', Frontiers in Psychology, vol. 13, pp. 957308 . https://doi.org/10.3389/fpsyg.2022.957308
Frontiers in psychology 13, 957308 (2022). doi:10.3389/fpsyg.2022.957308

IntroductionSeveral lifestyle factors promote protection against Alzheimer's disease (AD) throughout a person's lifespan. Although such protective effects have been described for occupational cognitive requirements (OCR) in midlife, it is currently u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5440cb5e7e5d0230354048add72c0c62
https://www.pure.ed.ac.uk/ws/files/319756584/fpsyg_13_957308_2_.pdf