Zobrazeno 1 - 10
of 25
pro vyhledávání: '"J. Mike Southern"'
Publikováno v:
Chemical Communications. 56:3915-3918
Eukaryotic tRNA-guanine transglycosylase (TGT) - an enzyme recently recognised to be of potential therapeutic importance - catalyses base-exchange of guanine for queuine at the wobble position of tRNAs associated with 4 amino acids via a distinct mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1775aa19abc10237a29f2d170a652e8
https://doi.org/10.1039/c9cc09887a
https://doi.org/10.1039/c9cc09887a
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 59:128545
An investigation into the effect of modified β-lysines on the growth rates of eubacterial cells is reported. It is shown that the effects observed are due to the post translational modification of Elongation Factor P (EFP) with these compounds catal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e446808295eed0f53926e02bcee387
https://doi.org/10.1016/j.bmcl.2022.128545
https://doi.org/10.1016/j.bmcl.2022.128545
Autor:
Isabel Bermudez, Susan Wonnacott, Neasa McNabola, Emily H. Clark, J. Mike Southern, David Mangan
Publikováno v:
Organicbiomolecular chemistry. 17(46)
The synthesis of novel mecamylamine analogues is described in which one, two or three of the methyl groups of mecamylamine have been systematically replaced with ethyl groups. Assessment of the compounds highlights that simple ethyl for methyl change
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f1a88fba1e2f0ca470b838835ddae4
https://pubmed.ncbi.nlm.nih.gov/31713564
https://pubmed.ncbi.nlm.nih.gov/31713564
Autor:
Isabel Bermudez, David Mangan, Susan Wonnacott, Emily H. Clark, J. Mike Southern, Neasa McNabola
Publikováno v:
Organic & Biomolecular Chemistry. 14:10787-10798
A new synthesis of mecamylamine - a known anti-hypertensive drug with anti-addictive properties is described. The new route allowed access to two novel analogues whose activity at two nicotinic acetylcholine receptor subtypes was assessed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8396a5d156ea3a52e5e86cc867d5e181
https://doi.org/10.1039/c6ob01974a
https://doi.org/10.1039/c6ob01974a
Publikováno v:
Tetrahedron. 71:4598-4603
A one-pot approach to the synthesis of 3-nitrothiophene and 3-nitro-2-substituted thiophenes has been developed. Exposure of 1,4-dithane-2,5-diol to nitroacetates or nitroalkenes in the presence of 25% triethylamine and subsequent treatment with mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::954df66a7adf69711992ee92c3e20b0e
https://doi.org/10.1016/j.tet.2015.05.032
https://doi.org/10.1016/j.tet.2015.05.032
Autor:
Cornelius J. O' Connor, J. Mike Southern, Michael D. Wall, Mark D. Roydhouse, Anna M. Przybyl
Publikováno v:
The Journal of Organic Chemistry. 75:2534-2538
A new approach to 3-nitro-2-substituted thiophenes has been developed. Exposure of commercially available 1,4-dithane-2,5-diol to nitroalkenes in the presence of 20% triethylamine results in a tandem Michael-intramolecular Henry reaction to form the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4401d54d250b699abd33494cd6338d9
https://doi.org/10.1021/jo902656y
https://doi.org/10.1021/jo902656y
Publikováno v:
ChemInform. 46
A one-pot approach to the synthesis of 3-nitrothiophene and 3-nitro-2-substituted thiophenes has been developed. Exposure of 1,4-dithane-2,5-diol to nitroacetates or nitroalkenes in the presence of 25% triethylamine and subsequent treatment with mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23e63dad1553a1731dcd3ee7ae68b4a4
https://doi.org/10.1002/chin.201542138
https://doi.org/10.1002/chin.201542138
Publikováno v:
Tetrahedron Letters. 42:8251-8254
N -Alkyl hydroxylamines have been shown to undergo a highly stereospecific cis addition to α,β-unsaturated sulfones, nitriles and nitro compounds.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ff5cbf95d69e8231fd0149eed3e7553
https://doi.org/10.1016/s0040-4039(01)01746-4
https://doi.org/10.1016/s0040-4039(01)01746-4
Publikováno v:
Synlett. 2008:2158-2160
Cyclisation of a sulfenic acid and an alkene to generate 4-thiosugars has been developed. The first example of the cyclisation of a sulfenic acid and a vinyl chloride is included.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29d9edf5921ea207f56f9d1ff05e7136
https://doi.org/10.1055/s-2008-1078027
https://doi.org/10.1055/s-2008-1078027
Autor:
Ian A. O'Neil, J. Mike Southern
Publikováno v:
Tetrahedron Letters. 39:9089-9092
Functionalised epoxides have been found to undergo high yielding and regioselective ring opening with hydroxylamines in methanol to give β-hydroxyhydroxylamines. Suitable substrates were found to undergo a reverse Cope cyclisation on heating in CHCl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c50963f628de18fc9e73c99dda5ea5d5
https://doi.org/10.1016/s0040-4039(98)02001-2
https://doi.org/10.1016/s0040-4039(98)02001-2