Zobrazeno 1 - 10
of 263
pro vyhledávání: '"J. Metge"'
Autor:
Brandon J. Metge, Heba Allah M. Alsheikh, Sarah C. Kammerud, Dongquan Chen, Devika Das, N. Miranda Nebane, J. Robert Bostwick, Lalita A. Shevde, Rajeev S. Samant
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-14 (2024)
Abstract Metastatic dissemination from the primary tumor is a complex process that requires crosstalk between tumor cells and the surrounding milieu and involves the interplay between numerous cellular-signaling programs. Epithelial–mesenchymal tra
Externí odkaz:
https://doaj.org/article/fdb5e2dddfe24017af39bdd3f65354a8
Autor:
Brandon J. Metge, Heba A. Alsheikh, Dongquan Chen, Amr R. Elhamamsy, Dominique C. Hinshaw, Bo-Ruei Chen, Barry P. Sleckman, Rajeev S. Samant, Lalita A. Shevde
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-15 (2023)
Abstract Hyperactivated ribosome biosynthesis is attributed to a need for elevated protein synthesis that accommodates cell growth and division, and is characterized by nucleomorphometric alterations and increased nucleolar counts. Ribosome biogenesi
Externí odkaz:
https://doaj.org/article/b2323fac90854d5292281b8d83c481fc
Autor:
Heba Allah M. Alsheikh, Brandon J. Metge, Hawley C. Pruitt, Sarah C. Kammerud, Dongquan Chen, Shi Wei, Lalita A. Shevde, Rajeev S. Samant
Publikováno v:
Oncogenesis, Vol 10, Iss 6, Pp 1-11 (2021)
Abstract Molecular dynamics of developmental processes are repurposed by cancer cells to support cancer initiation and progression. Disruption of the delicate balance between cellular differentiation and plasticity during mammary development leads to
Externí odkaz:
https://doaj.org/article/20b78b1d4c554e3aabb89d8344b10c60
Autor:
Mateus Mota, Brandon J. Metge, Dominique C. Hinshaw, Heba A. Alsheikh, Dongquan Chen, Rajeev S. Samant, Lalita A. Shevde
Publikováno v:
Molecular Oncology, Vol 15, Iss 4, Pp 942-956 (2021)
The expression of Merlin tumor suppressor protein encoded by Neurofibromin 2 (NF2) gene is remarkably decreased in metastatic breast cancer tissues. In order to recapitulate clinical evidence, we generated a unique, conditional Nf2‐knockout (Nf2−
Externí odkaz:
https://doaj.org/article/1835e7e70c3742fa93b7740ef879fdcc
Autor:
Shannon E. Weeks, Sarah C. Kammerud, Brandon J. Metge, Heba A. AlSheikh, David A. Schneider, Dongquan Chen, Shi Wei, James A. Mobley, Akinyemi I. Ojesina, Lalita A. Shevde, Rajeev S. Samant
Publikováno v:
Cell Death and Disease, Vol 12, Iss 3, Pp 1-13 (2021)
Abstract Triple-negative breast cancer (TNBC) patients with upregulated Wnt/β-catenin signaling often have poor clinical prognoses. During pathological examinations of breast cancer sections stained for β-catenin, we made the serendipitous observat
Externí odkaz:
https://doaj.org/article/9501db756b5244c1bd2c083ff6d813b3
Autor:
Dominique C. Hinshaw, Gloria A. Benavides, Brandon J. Metge, Courtney A. Swain, Sarah C. Kammerud, Heba A. Alsheikh, Amr Elhamamsy, Dongquan Chen, Victor Darley-Usmar, Jeffrey C. Rathmell, Robert S. Welner, Rajeev S. Samant, Lalita A. Shevde
Publikováno v:
Cancer Immunology Research. 11:687-702
The tumor immune microenvironment dynamically evolves to support tumor growth and progression. Immunosuppressive regulatory T cells (Treg) promote tumor growth and metastatic seeding in patients with breast cancer. Deregulation of plasticity between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1828ea8a49f25dbc1cbb49be11be1035
https://doi.org/10.1158/2326-6066.cir-22-0426
https://doi.org/10.1158/2326-6066.cir-22-0426
Publikováno v:
iScience, Vol 24, Iss 1, Pp 102010- (2021)
Summary: Hypoxia is one of the critical stressors encountered by various cells of the human body under diverse pathophysiologic conditions including cancer and has profound impacts on several metabolic and physiologic processes. Hypoxia prompts inter
Externí odkaz:
https://doaj.org/article/4f7f5d640a464387bf83baa46b410fa8
Autor:
Ann Hanna, Brandon J. Metge, Sarah K. Bailey, Dongquan Chen, Darshan S. Chandrashekar, Sooryanarayana Varambally, Rajeev S. Samant, Lalita A. Shevde
Publikováno v:
OncoImmunology, Vol 8, Iss 3 (2019)
Host responses to tumor cells include tumor suppressing or promoting mechanisms. We sought to detail the effect of Hedgehog (Hh) pathway inhibition on the composition of the mammary tumor immune portfolio. We hypothesized that Hh signaling mediates a
Externí odkaz:
https://doaj.org/article/7d5f821a0a1e412481c97966dc2af642
Autor:
Lalita A. Shevde, Rajeev S. Samant, Robert S. Welner, Jeffrey C. Rathmell, Victor Darley-Usmar, Dongquan Chen, Amr Elhamamsy, Heba A. Alsheikh, Sarah C. Kammerud, Courtney A. Swain, Brandon J. Metge, Gloria A. Benavides, Dominique C. Hinshaw
The tumor immune microenvironment dynamically evolves to support tumor growth and progression. Immunosuppressive regulatory T cells (Treg) promote tumor growth and metastatic seeding in patients with breast cancer. Deregulation of plasticity between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54bb51e17ee046fee5ad006653e206e9
https://doi.org/10.1158/2326-6066.c.6600106.v2
https://doi.org/10.1158/2326-6066.c.6600106.v2
Autor:
Donald J. Buchsbaum, Yonghe Li, Albert F. LoBuglio, Andres Forero-Torres, Michael Conner, William E. Grizzle, Bertha Hidalgo, Brandon J. Metge, Rajeev S. Samant, Wenyan Lu, Laura Aristizabal, Rebecca C. Arend, Angelina I. Londoño-Joshi
PDF file - 96KB, Supplementary Figure S4. Wnt/beta-catenin signaling proteins in LRP6 KD cells. Western blot for expression of Wnt/beta-catenin signaling proteins in adherent 2LMP shRNA LRP6 knockdown cells compared to shRNA control cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62391a1fdd262bc11149ca51aa330ba1
https://doi.org/10.1158/1535-7163.22501198.v1
https://doi.org/10.1158/1535-7163.22501198.v1