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Akademický článek

Genetic pharmacotherapy as an early CNS drug development strategy: testing glutaminase inhibition for schizophrenia treatment in adult mice

Autor: Susana eMingote, Justine eMasson, Celia eGellman, Gretchen Miller Thomsen, Chyuan-Sheng eLin, Robert J. Merker, Inna eGaisler-Salomon, Yvonne eWang, Rachel eErnst, Rene eHen, Stephen eRayport

Publikováno v: Frontiers in Systems Neuroscience, Vol 9 (2016)

Genetic pharmacotherapy is an early drug development strategy for the identification of novel CNS targets in mouse models prior to the development of specific ligands. Here for the first time, we have implemented this strategy to address the potentia

Externí odkaz: https://doaj.org/article/0dddaffeafe1437387af34bb6b43a440

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Inklusion chronisch kranker Kinder und Jugendlicher in den Schulsport

Autor: J. Merker, M. Hartmann, N. Henner

Publikováno v: Arthritis und Rheuma. 38:408-415

ZusammenfassungChronische Erkrankungen verursachen im Kindesalter bisweilen erhebliche Auswirkungen auf die Funktionalität und körperliche Aktivität. Die Inklusion in den Schulsport ist von hoher Bedeutung und in den meisten Fällen möglich. Ein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f55793a79a630fb5bbda6d3c28a58056
https://doi.org/10.1055/s-0038-1677362

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Accuracy and precision of loadsol®insole force-sensors for the quantification of ground reaction force-based biomechanical running parameters

Autor: Ansgar Schwirtz, Marco Leitel, Elisabeth Jensen, Wolfgang Seiberl, J. Merker

Publikováno v: European Journal of Sport Science. 18:1100-1109

Force plates represent the “gold standard” in measuring running kinetics to predict performance or to identify the sources of running-related injuries. As these measurements are generally limited t...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48df7f5739b2dc5aa40c5514f69f00f8
https://doi.org/10.1080/17461391.2018.1477993

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Akademický článek

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AB1023 PHYSICAL ACTIVITY LEVEL IN PATIENTS WITH JUVENILE IDIOPATHIC ARTHRITISIN THE GERMAN NATIONAL PAEDIATRIC RHEUMATOLOGIC DATABASE: A COMPARISON WITH THE GENERAL POPULATION

Autor: M. Hartmann, J. Hörstermann, Peter Haas, Gerd Horneff, Tilmann Kallinich, Joachim Peitz, Martina Niewerth, N. Geisemeyer, F. Milatz, J. Merker, Kirsten Minden

Publikováno v: Abstracts Accepted for Publication.

Background Insights in pathogenesis and the availability of new biologic drugs have created requirements and an increasing interest for encouragement of physical activity (PA) as long-term treatment option in patients with juvenile idiopathic arthrit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9193bff65b53c3dac8563a5836eefe9b
https://doi.org/10.1136/annrheumdis-2019-eular.6031

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Biomechanics of walking in adolescents with progressive pseudorheumatoid arthropathy of childhood leads to physical activity recommendations as therapeutic focus

Autor: Ansgar Schwirtz, R. Haefner, M. Hartmann, J. Merker, Johannes-Peter Haas

Publikováno v: Clinical Biomechanics. 31:93-99

Background Progressive pseudorheumatoid arthropathy of childhood is a rare disease with an estimated prevalence of approximately 1/1,000,000. The disease manifests around the age of three to eight years and progresses with symptoms of early fatigue,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f861a68abb3ef37e00cbba6f0e3049
https://doi.org/10.1016/j.clinbiomech.2015.09.015

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[Back to school physical education despite rheumatism : Development and testing of a sport scientific-based physical education certification]

Autor: M, Hartmann, J, Merker, S, Schrödl, M, König, M, Georgi, C, Hinze, A, Schwirtz, J-P, Haas

Publikováno v: Zeitschrift fur Rheumatologie. 77(8)

Taking part in physical education is an important element of social participation for children with chronic diseases. Nevertheless, children suffering from rheumatism mostly receive recommendations to stop sport activities either completely or partia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::92838a41743f4d1b020cb0f06047804b
https://pubmed.ncbi.nlm.nih.gov/30069740

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Combined three-dimensional gait and plantar pressure analyses detecting significant functional deficits in children with juvenile idiopathic arthritis

Autor: J. Merker, Johannes-Peter Haas, Ansgar Schwirtz, M. Hartmann

Publikováno v: Gaitposture. 66

Background Children suffering from juvenile idiopathic arthritis (JIA), a heterogeneous group of chronic inflammatory joint diseases, adapt to individual gait patterns to avoid loading of inflamed, swollen and painful joints. As the interpretability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b58ec0a98378dc6bfe541e0f4cbf18
https://pubmed.ncbi.nlm.nih.gov/30218839

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