Zobrazeno 1 - 10
of 221
pro vyhledávání: '"J. Meakin"'
Autor:
Bashayer R. Al-Mubarak, Karen F.S. Bell, Sudhir Chowdhry, Paul J. Meakin, Paul S. Baxter, Sean McKay, Owen Dando, Michael L.J. Ashford, Irina Gazaryan, John D. Hayes, Giles E. Hardingham
Publikováno v:
Redox Biology, Vol 47, Iss , Pp 102158- (2021)
The transcription factor Nrf2 is a stress-responsive master regulator of antioxidant, detoxification and proteostasis genes. In astrocytes, Nrf2-dependent gene expression drives cell-autonomous cytoprotection and also non-cell-autonomous protection o
Externí odkaz:
https://doaj.org/article/bfac644fbd9a4a15bd392002c220b8e0
Autor:
Paul J. Meakin, Anna Mezzapesa, Eva Benabou, Mary E. Haas, Bernadette Bonardo, Michel Grino, Jean-Michel Brunel, Christèle Desbois-Mouthon, Sudha B. Biddinger, Roland Govers, Michael L. J. Ashford, Franck Peiretti
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
A soluble form of insulin receptor in human plasma has been previously reported. Here the authors demonstrate that insulin receptor is cleaved by BACE1 that can regulate biological active insulin receptor levels in a glucose concentration-dependent m
Externí odkaz:
https://doaj.org/article/527a3cb8a7ee44ba84d8fe3536cdc213
Autor:
Christopher. W. Wasson, Eva. M. Clavane, Rebecca. L. Ross, Gemma Migneco, Cristina Antinozzi, Jane. M. Y. Brown, Luigi Di Luigi, Clive. S. McKimmie, Francesco Del Galdo, Paul. J. Meakin
BackgroundThe beta-amyloid precursor protein cleaving enzyme 1 (BACE1) is well known for its role in the development of Alzheimer’s disease via the generation of β-amyloid. Recent publications, including our own, have demonstrated a role for this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65c1f79584eb3b2ec24beeb008fbb637
https://doi.org/10.1101/2022.12.22.521579
https://doi.org/10.1101/2022.12.22.521579
Autor:
Zachary J. Meakin, Andrés N. Richards Gonzales, Joshua R. Booth, Ross W. Jaggers, Robert A. Young, Stefan Antonius Franciscus Bon, Corinna M. Preuss-Weber
Publikováno v:
Journal of Materials Chemistry C. 9:7174-7185
Prototypes of flexible, electricity-free, ice warning signs for roads and pavements have been developed. A temperature triggered response in the form of an upper critical solution temperature (UCST) type phase separation targeted near the freezing po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8260faebef9fce370fe9bbca5f790d6a
https://doi.org/10.1039/d1tc01189h
https://doi.org/10.1039/d1tc01189h
Autor:
Hannah A. Taylor, Katie J. Simmons, Eva M. Clavane, Christopher J. Trevelyan, Jane M. Brown, Lena Przemyłska, Nicole T. Watt, Laura C. Matthews, Paul J. Meakin
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 9; Pages: 4568
The β-site Amyloid precursor protein Cleaving Enzyme 1 (BACE1) is an extensively studied therapeutic target for Alzheimer’s disease (AD), owing to its role in the production of neurotoxic amyloid beta (Aβ) peptides. However, despite numerous BACE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600584819b99fb9da8848ef1c29f1105
https://pubmed.ncbi.nlm.nih.gov/35562959
https://pubmed.ncbi.nlm.nih.gov/35562959
Autor:
Kenneth R. Watterson, Dawn Bestow, Jennifer Gallagher, D. Lee Hamilton, Fiona B. Ashford, Paul J. Meakin, Michael L.J. Ashford
Publikováno v:
Neurosignals, Vol 21, Iss 1-2, Pp 28-41 (2012)
Activation of mammalian target of rapamycin 1 (mTORC1) by nutrients, insulin and leptin leads to appetite suppression (anorexia). Contrastingly, increased AMP-activated protein kinase (AMPK) activity by ghrelin promotes appetite (orexia). However, th
Externí odkaz:
https://doaj.org/article/1e8e1898b1364d0e9499449a65c5fd65
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2441
The fibrin gel angiogenesis bead assay provides a controlled in vitro setting for observing endothelial angiogenic sprouting in response to modified variables. Endothelial cells are coated onto microcarriers and embedded into a fibrin clot containing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2bb347394573b18f439de9a0fac5281f
https://pubmed.ncbi.nlm.nih.gov/35099748
https://pubmed.ncbi.nlm.nih.gov/35099748
Publikováno v:
Obesity reviews : an official journal of the International Association for the Study of Obesity. 23(7)
β-site amyloid precursor protein cleaving enzyme-1 (BACE1) research has historically focused on its actions as the β-secretase responsible for the production of β-amyloid beta, observed in Alzheimer's disease. Although the greatest expression of B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376195bee909af3d80be877bcf12f706
https://pubmed.ncbi.nlm.nih.gov/35119166
https://pubmed.ncbi.nlm.nih.gov/35119166
Publikováno v:
Methods in Molecular Biology ISBN: 9781071620588
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::791706bb3831a7d197ab99d92c206f1b
https://doi.org/10.1007/978-1-0716-2059-5_25
https://doi.org/10.1007/978-1-0716-2059-5_25
A small molecule reveals role of insulin receptor-insulin like growth factor-1 receptor heterodimers
Autor:
Katie J Simmons, Chloe G Myers, Hema Viswambharan, Natalie J Haywood, Katherine Bridge, Samuel Turvey, Thomas Armstrong, Lydia Lunn, Paul J Meakin, Eva Clavane, David J Beech, Richard M Cubbon, Stephen B Wheatcroft, Martin J McPhillie, Colin WG Fishwick, Mark T Kearney
The insulin receptor and insulin like growth factor-1 receptor are heterodimers consisting of two extracellular α-subunits and two transmembrane β-subunits. IR αβ and IGF1R αβ hemi-receptors can heterodimerize to form hybrids composed of one IR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec7fd96d1aaf40f083426479d78383f7
https://doi.org/10.1101/2021.12.09.471780
https://doi.org/10.1101/2021.12.09.471780