Zobrazeno 1 - 10
of 759
pro vyhledávání: '"J. McConville"'
MLKL deficiency elevates testosterone production in male mice independently of necroptotic functions
Autor:
Shene Chiou, Wayne Cawthorne, Thomas Soerianto, Vinzenz Hofferek, Komal M. Patel, Sarah E. Garnish, Emma C. Tovey Crutchfield, Cathrine Hall, Joanne M. Hildebrand, Malcolm J. McConville, Kate E. Lawlor, Edwin D. Hawkins, Andre L. Samson, James M. Murphy
Publikováno v:
Cell Death and Disease, Vol 15, Iss 11, Pp 1-10 (2024)
Abstract Mixed lineage kinase domain-like (MLKL) is a pseudokinase, best known for its role as the terminal effector of the necroptotic cell death pathway. MLKL-mediated necroptosis has long been linked to various age-related pathologies including ne
Externí odkaz:
https://doaj.org/article/3e983790f4d740f6875bec76ced943af
Autor:
Andre Mu, William P. Klare, Sarah L. Baines, C. N. Ignatius Pang, Romain Guérillot, Nichaela Harbison-Price, Nadia Keller, Jonathan Wilksch, Nguyen Thi Khanh Nhu, Minh-Duy Phan, Bernhard Keller, Brunda Nijagal, Dedreia Tull, Saravanan Dayalan, Hwa Huat Charlie Chua, Dominik Skoneczny, Jason Koval, Abderrahman Hachani, Anup D. Shah, Nitika Neha, Snehal Jadhav, Sally R. Partridge, Amanda J. Cork, Kate Peters, Olivia Bertolla, Stephan Brouwer, Steven J. Hancock, Laura Álvarez-Fraga, David M. P. De Oliveira, Brian Forde, Ashleigh Dale, Warasinee Mujchariyakul, Calum J. Walsh, Ian Monk, Anna Fitzgerald, Mabel Lum, Carolina Correa-Ospina, Piklu Roy Chowdhury, Robert G. Parton, James De Voss, James Beckett, Francois Monty, Jessica McKinnon, Xiaomin Song, John R. Stephen, Marie Everest, Matt I. Bellgard, Matthew Tinning, Michael Leeming, Dianna Hocking, Leila Jebeli, Nancy Wang, Nouri Ben Zakour, Serhat A. Yasar, Stefano Vecchiarelli, Tonia Russell, Thiri Zaw, Tyrone Chen, Don Teng, Zena Kassir, Trevor Lithgow, Adam Jenney, Jason N. Cole, Victor Nizet, Tania C. Sorrell, Anton Y. Peleg, David L. Paterson, Scott A. Beatson, Jemma Wu, Mark P. Molloy, Anna E. Syme, Robert J. A. Goode, Adam A. Hunter, Grahame Bowland, Nicholas P. West, Marc R. Wilkins, Steven P. Djordjevic, Mark R. Davies, Torsten Seemann, Benjamin P. Howden, Dana Pascovici, Sonika Tyagi, Ralf B. Schittenhelm, David P. De Souza, Malcolm J. McConville, Jonathan R. Iredell, Stuart J. Cordwell, Richard A. Strugnell, Timothy P. Stinear, Mark A. Schembri, Mark J. Walker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Severe sepsis has a high mortality rate. Here, the authors provide genomic, transcriptomic, proteomic and metabolomic data across four sepsis-causing pathogens and identify a signature of global increase in fatty acid and lipid biosynthesis as well a
Externí odkaz:
https://doaj.org/article/6d65b18b91de403488fe5eca204df6be
Autor:
Michael F. Duffy, Gerry Q. Tonkin-Hill, Leily Trianty, Rintis Noviyanti, Hanh H. T. Nguyen, Janavi S. Rambhatla, Malcolm J. McConville, Stephen J. Rogerson, Graham V. Brown, Ric N. Price, Nicholas M. Anstey, Karen P. Day, Anthony T. Papenfuss
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/4568f818a26f4356ab0ac8724eb7bce5
Autor:
Tianyao Lu, Lutz Freytag, Vinod K. Narayana, Zachery Moore, Shannon J. Oliver, Adam Valkovic, Brunda Nijagal, Amanda L. Peterson, David P. de Souza, Malcolm J. McConville, James R. Whittle, Sarah A. Best, Saskia Freytag
Publikováno v:
Metabolites, Vol 13, Iss 11, p 1139 (2023)
Matrix-assisted laser desorption/ionization mass spectrometry imaging allows for the study of metabolic activity in the tumor microenvironment of brain cancers. The detectable metabolites within these tumors are contingent upon the choice of matrix,
Externí odkaz:
https://doaj.org/article/73a321252ad34bad8514e084e50fd8a7
Autor:
Farheen Farzana, Malcolm J. McConville, Thibault Renoir, Shanshan Li, Shuai Nie, Harvey Tran, Anthony J. Hannan, Danny M. Hatters, Berin A. Boughton
Publikováno v:
Neurobiology of Disease, Vol 176, Iss , Pp 105933- (2023)
In Huntington's disease (HD), a key pathological feature includes the development of inclusion-bodies of fragments of the mutant huntingtin protein in the neurons of the striatum and hippocampus. To examine the molecular changes associated with inclu
Externí odkaz:
https://doaj.org/article/076bba59de224e7fbf2275e6dd517b20
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The respiratory tract is a gateway for viruses and bacteria from the external environment to invade the human body. Critical to the protection against these invaders are dendritic cells (DCs) - a group of highly specialized myeloid cells that monitor
Externí odkaz:
https://doaj.org/article/d8ef80e78d5348f4ba01b7d9a00e52f3
Autor:
Simon A Cobbold, Madel V Tutor, Philip Frasse, Emma McHugh, Markus Karnthaler, Darren J Creek, Audrey Odom John, Leann Tilley, Stuart A Ralph, Malcolm J McConville
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 4, Pp 1-20 (2021)
Abstract The malaria parasite, Plasmodiumfalciparum, proliferates rapidly in human erythrocytes by actively scavenging multiple carbon sources and essential nutrients from its host cell. However, a global overview of the metabolic capacity of intraer
Externí odkaz:
https://doaj.org/article/85219461186340c79d8c14ae42b6810f
Autor:
Sarah H. Shafik, Simon A. Cobbold, Kawthar Barkat, Sashika N. Richards, Nicole S. Lancaster, Manuel Llinás, Simon J. Hogg, Robert L. Summers, Malcolm J. McConville, Rowena E. Martin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Plasmodium falciparum chloroquine resistance transporter (PfCRT) mediates multidrug resistance, but its natural function remains unclear. Here, Shafik et al. show that PfCRT transports host-derived peptides of 4-11 residues but not other ions or meta
Externí odkaz:
https://doaj.org/article/e62a9cfeb1b74e3793184dbfb72b16f7
Autor:
Kylie M. Quinn, Tabinda Hussain, Felix Kraus, Luke E. Formosa, Wai K. Lam, Michael J. Dagley, Eleanor C. Saunders, Lisa M. Assmus, Erica Wynne-Jones, Liyen Loh, Carolien E. van de Sandt, Lucy Cooper, Kim L. Good-Jacobson, Katherine Kedzierska, Laura K. Mackay, Malcolm J. McConville, Georg Ramm, Michael T. Ryan, Nicole L. La Gruta
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Fatty acid oxidation (FAO) is thought to contribute to high spare respiratory capacity (SRC), which in turn affects CD8+ T cell function. Here, the authors show that ex vivo virtual memory T cells (and not antigen experienced memory T cells) have hig
Externí odkaz:
https://doaj.org/article/6da73ceced984a059e48b4f7619a183a
Autor:
Kevin X. Lau, Elizabeth A. Mason, Joshua Kie, David P. De Souza, Joachim Kloehn, Dedreia Tull, Malcolm J. McConville, Andrew Keniry, Tamara Beck, Marnie E. Blewitt, Matthew E. Ritchie, Shalin H. Naik, Daniela Zalcenstein, Othmar Korn, Shian Su, Irene Gallego Romero, Catrina Spruce, Christopher L. Baker, Tracy C. McGarr, Christine A. Wells, Martin F. Pera
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Human pluripotent cells (hPSCs) in standard culture are similar to mouse epiblast cells, but heterogeneity within hPSC cultures complicates comparisons. Here the authors show that a subpopulation of hPSCs enriched for self-renewal capacity have disti
Externí odkaz:
https://doaj.org/article/1f87c566710a45a38bb6a81fc0b27bcc