Zobrazeno 1 - 10
of 34
pro vyhledávání: '"J. Matthew Rhett"'
Autor:
Imran Khan, Akiko Koide, Mariyam Zuberi, Gayatri Ketavarapu, Eric Denbaum, Kai Wen Teng, J. Matthew Rhett, Russell Spencer-Smith, G. Aaron Hobbs, Ernest Ramsay Camp, Shohei Koide, John P. O'Bryan
Publikováno v:
Cell Reports, Vol 38, Iss 6, Pp 110322- (2022)
Summary: RAS guanosine triphosphatases (GTPases) are mutated in nearly 20% of human tumors, making them an attractive therapeutic target. Following our discovery that nucleotide-free RAS (apo RAS) regulates cell signaling, we selectively target this
Externí odkaz:
https://doaj.org/article/c9a4430bc9ea408bb3a1d81302e52240
Autor:
Joelle N. Zambrano, Scott T. Eblen, Melissa Abt, J. Matthew Rhett, Robin Muise-Helmericks, Elizabeth S. Yeh
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 22, p 5813 (2019)
Background: Autophagy is a catabolic cellular recycling pathway that is essential for maintaining intracellular homeostasis. Autophagosome formation is achieved via the coordination of the Beclin-1 protein complex. Rubicon is a Beclin-1 associated pr
Externí odkaz:
https://doaj.org/article/4848286a19f745f9915a01762fabf57e
Publikováno v:
Journal of Diabetes Research, Vol 2016 (2016)
Total pancreatectomy and islet autotransplantation is a cutting-edge technique to treat chronic pancreatitis and postoperative diabetes. A major obstacle has been low islet cell survival due largely to the innate inflammatory response. Connexin43 (Cx
Externí odkaz:
https://doaj.org/article/5910f63da170480886ae9da5f469ed8f
Autor:
J. Matthew Rhett, Elizabeth S. Yeh
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 4, p 1043 (2018)
Over the past few decades, connexin hemichannels have become recognized as major players in modulating the inflammatory response. Chronic inflammation is documented to promote tumorigenesis and is a critical component of tumor progression. Furthermor
Externí odkaz:
https://doaj.org/article/37bb366fef6f4099b9b1f951de0d0f7c
Autor:
Gabriel Virella, Suzanne R. Thorpe, Nathan L. Alderson, M. Brooks Derrick, Charlyne Chassereau, J. Matthew Rhett, Maria F. Lopes-Virella
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 10, Pp 1859-1867 (2004)
Humans and laboratory animals recognize human modified LDL as immunogenic. Immune complexes (ICs) isolated from human sera contain malondialdehyde-modified LDL (MDA-LDL) and N ε(carboxymethyl)lysine-modified LDL (CML-LDL) as well as antibodies react
Externí odkaz:
https://doaj.org/article/849fa92d82034bf7958d07475752ed3f
Abstract B023: Inhibition of RAS signaling and tumorigenesis through targeting novel vulnerabilities
Autor:
Imran Kahn, Akiko Koide, Mariyam Zuberi, Gayatri Ketavarapu, Eric Denbaum, Kai Wen Teng, J. Matthew Rhett, Russell Spencer-Smith, G. Aaron Hobbs, Earnest Ramsay Camp, Shohei Koide, John P. O'Bryan
Publikováno v:
Molecular Cancer Research. 21:B023-B023
RAS GTPases are important mediators of oncogenesis with nearly 30% of human tumors harboring mutant RAS proteins. However, pharmacological inhibition of RAS has proven challenging. We have employed Monobody technology to discover novel vulnerabilitie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e59dc84a8514a1c5bd262386625793a9
https://doi.org/10.1158/1557-3125.ras23-b023
https://doi.org/10.1158/1557-3125.ras23-b023
Autor:
Francis Bustos, Katherine E. Degen, Jeffrey W. Holmes, L. Jane Jourdan, J. Matthew Rhett, Robert G. Gourdie, William J. Richardson, Gautam S. Ghatnekar, Christina L. Grek, Jade Montgomery, Spencer R. Marsh
Publikováno v:
FASEB J
Phase II clinical trials have reported that acute treatment of surgical skin wounds with the therapeutic peptide alpha Connexin Carboxy-Terminus 1 (αCT1) improves cutaneous scar appearance by 47% 9-month postsurgery. While Cx43 and ZO-1 have been id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea443561350c6884f265f32b8ff6cd6
https://europepmc.org/articles/PMC8667734/
https://europepmc.org/articles/PMC8667734/
Autor:
Robert G. Gourdie, William J. Richardson, Francis Bustos, Christina L. Grek, J. Matthew Rhett, Katherine E. Degen, L. Jane Jourdan, Spencer R. Marsh, Jeffrey W. Holmes, Jade Montgomery, Gautam S. Ghatnekar
Phase II clinical trials have reported that acute treatment of surgical skin wounds with the therapeutic peptide αCT1 improves cutaneous scar appearance by 47% 9-months post-surgery – though mode-of-action remains unknown. Scar matrix structure in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efc85eb88a735d7442547d6b27b3565d
https://doi.org/10.1101/2020.07.07.191742
https://doi.org/10.1101/2020.07.07.191742
Publikováno v:
Advances in Cancer Research ISBN: 9780128203279
Adv Cancer Res
Adv Cancer Res
RAS was identified as a human oncogene in the early 1980s and subsequently found to be mutated in nearly 30% of all human cancers. More importantly, RAS plays a central role in driving tumor development and maintenance. Despite decades of effort, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227d7f68df8b3e49f393e2762eb4d5c1
https://doi.org/10.1016/bs.acr.2020.05.002
https://doi.org/10.1016/bs.acr.2020.05.002
Autor:
Robert G. Gourdie, Heather Bainbridge, Bennett W. Calder, J. Matthew Rhett, Stephen A. Fann, Michael J. Yost
Publikováno v:
American Journal of Physiology-Cell Physiology. 313:C314-C326
Connexin-based therapeutics have shown the potential for therapeutic efficacy in improving wound healing. Our previous work demonstrated that the connexin43 (Cx43) mimetic peptide juxtamembrane 2 (JM2) reduced the acute inflammatory response to a sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25edef328c84301457657bd6e07b75a9
https://doi.org/10.1152/ajpcell.00229.2016
https://doi.org/10.1152/ajpcell.00229.2016