Výsledky vyhledávání - "J. Matthew Kofron"

Akademický článek

Single-cell sequencing dissects the transcriptional identity of activated fibroblasts and identifies novel persistent distal tubular injury patterns in kidney fibrosis

Autor: Valeria Rudman-Melnick, Mike Adam, Kaitlynn Stowers, Andrew Potter, Qing Ma, Saagar M. Chokshi, Davy Vanhoutte, Iñigo Valiente-Alandi, Diana M. Lindquist, Michelle L. Nieman, J. Matthew Kofron, Eunah Chung, Joo-Seop Park, S. Steven Potter, Prasad Devarajan

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)

Abstract Examining kidney fibrosis is crucial for mechanistic understanding and developing targeted strategies against chronic kidney disease (CKD). Persistent fibroblast activation and tubular epithelial cell (TEC) injury are key CKD contributors. H

Externí odkaz: https://doaj.org/article/fb7e56c701184434a55c7bc914d1b4b2

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Alveolar epithelial progenitor cells drive lung regeneration via dynamic changes in chromatin topology modulated by lineage-specific Nkx2-1 activity

Autor: Andrea Toth, Paranthaman Kannan, John Snowball, J. Matthew Kofron, Joseph A. Wayman, James P. Bridges, Emily R. Miraldi, Daniel Swarr, William J. Zacharias

Lung epithelial regeneration after acute injury requires coordination of extensive cellular and molecular processes controlling proliferation and differentiation of specialized alveolar cells to pattern the morphologically complex alveolar gas exchan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55accab49cc7bb2db64be0bbde0117f3
https://doi.org/10.1101/2022.08.30.505919

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In situ mapping identifies distinct vascular niches for myelopoiesis

Autor: Giang Pham, Margot Lindsay May, J. Matthew Kofron, Courtney Johnson, Daniel Lucas, Nathan Salomonis, Andre Olsson, Qingqing Wu, Sing Sing Way, V. B. Surya Prasath, Angelo D'Alessandro, Anastasiya Slaughter, Jeremy M. Kinder, Benjamin Weinhaus, Jizhou Zhang, James Douglas Engel, L. Frank Huang, H. Leighton Grimes, Jean X. Jiang

Publikováno v: Nature

In contrast to nearly all other tissues, the anatomy of cell differentiation in the bone marrow remains unknown. This is owing to a lack of strategies for examining myelopoiesis—the differentiation of myeloid progenitors into a large variety of inn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667f29b12816cb2a02711d03c9da1643
http://europepmc.org/articles/PMC8020897

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Resilient anatomy and local microplasticity of naïve and stress hematopoiesis

Autor: Qingqing Wu, Jizhou Zhang, Courtney B. Johnson, Anastasiya Slaughter, Benjamin Weinhaus, Morgan McKnight, Bryan E. Sherman, Tzu-Yu Shao, Baobao Song, Marie Dominique Filippi, H. Leighton Grimes, Sing Sing Way, J. Matthew Kofron, Daniel Lucas

The bone marrow has an extraordinary capacity to adjust blood cell production to meet physiological demands in response to insults. The spatial organization of normal and stress responses is largely unknown due to the lack of methods to visualize mos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c55b5e50586b37a85885388b27c3c1e3
https://doi.org/10.1101/2022.05.23.492315

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Single-Cell Profiling of AKI in a Murine Model Reveals Novel Transcriptional Signatures, Profibrotic Phenotype, and Epithelial-to-Stromal Crosstalk

Autor: Prasad Devarajan, Qing Ma, Andrew S. Potter, Meredith P. Schuh, Valeria Rudman-Melnick, Saagar M. Chokshi, J. Matthew Kofron, Mike Adam, Keri A. Drake, S. Steven Potter

Publikováno v: J Am Soc Nephrol

Background Current management of AKI, a potentially fatal disorder that can also initiate or exacerbate CKD, is merely supportive. Therefore, deeper understanding of the molecular pathways perturbed in AKI is needed to identify targets with potential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cbd15327997063d38ef222ebd51b322
https://doi.org/10.1681/asn.2020010052

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Single Cell Profiling of Acute Kidney Injury Reveals Novel Transcriptional Signatures, Mixed Identities and Epithelial-to-Stromal Crosstalk

Autor: J. Matthew Kofron, Prasad Devarajan, Mike Adam, Qing Ma, Saagar M. Chokshi, Meredith P. Schuh, Keri A. Drake, Andrew S. Potter, S. Steven Potter, Valeria Rudman-Melnick

SummaryAcute kidney injury (AKI) is a rapid decline of renal function, with an incidence of up to 67% of intensive care unit patients. Current treatments are merely supportive, emphasizing the need for deeper understanding that could lead to improved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ccff3fc2d17320f7f64b23106aeb2fe

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Stretch regulates expression and binding of chymotrypsin-like elastase 1 in the postnatal lung

Autor: Sheng Liu, Yan Xu, Sarah Marie Young, Karen S. Apsley, Rashika Joshi, Timmothy E. Weaver, Brian M. Varisco, Montell D. Brown, Matthew Batie, J. Matthew Kofron

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 30(2)

Lung stretch is critical for normal lung development and for compensatory lung growth after pneumonectomy (PNX), but the mechanisms by which strain induces matrix remodeling are unclear. Our prior work demonstrated an association of chymotrypsin-like

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103d1b8380b2739a72bb766b18309b05
https://pubmed.ncbi.nlm.nih.gov/26443822

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