Výsledky vyhledávání - "J. Masferrer"

COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer

Autor: J Anast, Alane Gresham, G Hruza, J. Masferrer, Alice P. Pentland, P Hale, S Y Buckman

Publikováno v: Carcinogenesis. 19:723-729

Extensive documentation has validated the role of UV irradiation as a tumor initiator and promoter, inducing both squamous and basal cell carcinomas. Human epidermis is a tissue which undergoes active metabolism of arachidonic acid to prostaglandins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a956513bae3df96311daebd2ce430d9
https://doi.org/10.1093/carcin/19.5.723

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COX-2 is expressed in human pulmonary, colonic, and mammary tumors

Autor: R A, Soslow, A J, Dannenberg, D, Rush, B M, Woerner, K N, Khan, J, Masferrer, A T, Koki

Publikováno v: Cancer. 89(12)

The cyclooxygenase (COX) enzyme catalyzes the formation of prostaglandins, which can affect cell proliferation and alter the response of the immune system to malignant cells. The inducible form of COX, COX-2, has been shown to be important in carcino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3306093de2a42650c4608e89a800107a
https://pubmed.ncbi.nlm.nih.gov/11135226

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Selective cyclooxygenase-2 inhibitors: heteroaryl modified 1,2-diarylimidazoles are potent, orally active antiinflammatory agents

Autor: Rita M. Huff, Yan Zhang, A. W. Veenhuizen, Jing Yuan, Karen Seibert, D.-C. Yang, Xiangdong Xu, C. M. Koboldt, P. W. Collins, Yi Yu, Richard Weier, J. N. Cogburn, Koszyk Francis, J. Masferrer, W. E. Perkins, Ish Kumar Khanna, Peter C. Isakson

Publikováno v: Journal of medicinal chemistry. 43(16)

A series of heteroaryl modified 1,2-diarylimidazoles has been synthesized and found to be potent and highly selective (1000-9000-fold) inhibitors of the human COX-2. 3-Pyridyl derived COX-2 selective inhibitor (25) exhibited excellent activity in acu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bfe34e90df25defe00df2c8d29d4cea
https://pubmed.ncbi.nlm.nih.gov/10956225

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Specific COX-2 inhibitors: from bench to bedside

Autor: J. Masferrer, B. Zweifel, P. Isakson, K. Seibert, S. Geis, P. Needleman, R. Hubbard, C. Koboldt

Publikováno v: Selective COX-2 Inhibitors ISBN: 9789401060417

Non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin have been used to treat various ailments for over 100 years. As a class, these drugs are anti-inflammatory, analgesic and anti-pyretic, and they are widely used to treat chronic inflammat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80d631085e2eb2175533b15b2cc0c0fe
https://doi.org/10.1007/978-94-011-4872-6_13

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Distribution of COX-1 and COX-2 in normal and inflamed tissues

Autor: K, Seibert, Y, Zhang, K, Leahy, S, Hauser, J, Masferrer, P, Isakson

Publikováno v: Advances in experimental medicine and biology.

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in the treatment of a number of inflammatory diseases and are believed to act via inhibition of the enzyme cyclooxygenase (COX). This enzyme catalyzes the conversion of arachidonic acid t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::665ec053b81c07bc6f75bbf8b581d0af
https://pubmed.ncbi.nlm.nih.gov/9547553

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FRI0003 Determination of interferon (IFN) signatures for sle patients may be critical for optimal treatment selection but depends on the genes chosen: report from the bold (biomarkers of lupus disease) study

Autor: Sudhakar Sridharan, P. W. Wu, Margot O'Toole, Andrew A. Hill, Immermann Frederick, Maryann Z. Whitley, T. Paradis, Joan T. Merrill, Judith A. James, J. Masferrer, Padmalatha S. Reddy, T. Zhou, Ying Zhang

Publikováno v: Annals of the Rheumatic Diseases. 72:A369.3-A370

Background Elevated expression of IFN pathway genes, known as the IFN signature (IS) is found in roughly half of SLE patients 1 . Various studies have used different IFN genes to define the IS, and different methods to assign patients to “IFN high�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b5e9b6a45ea46c5e46925946b5048f80
https://doi.org/10.1136/annrheumdis-2013-eular.1131

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OP0063 Impact of baseline interferon pathway activation on widespread gene expression changes with disease flare in lupus patients: Interim report from the bold (biomarkers of lupus disease) study

Autor: Maryann Z. Whitley, Padmalatha S. Reddy, Joan T. Merrill, W. Mounts, Attila A. Seyhan, T. Walker, T. Zhou, Immermann Frederick, Margot O'Toole, Sudhakar Sridharan, Ying Zhang, Andrew A. Hill, Judith A. James, Stan Kamp, Marek Honczarenko, J. Masferrer

Publikováno v: Annals of the Rheumatic Diseases. 71:74.2-74

Background Heterogeneity of clinical manifestations and underlying biology has confounded treatment development and optimal care of systemic lupus erythematosus (SLE) patients. About half of adult SLE patients tend to have stable, high expression lev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a87837fed6c2119cb690cc48730cdc98
https://doi.org/10.1136/annrheumdis-2012-eular.1746

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Increased synthesis of high-molecular-weight cPLA2 mediates early UV-induced PGE2 in human skin

Autor: Xi Chen, J. Masferrer, Alice P. Pentland, S. Leal-Khouri, Alane Gresham

Publikováno v: The American journal of physiology. 270(4 Pt 1)

Ultraviolet light (UV) B-induced inflammation is characterized by dramatic increases in prostaglandin E2 (PGE2) synthesis due to enhanced arachidonate deacylation from the membrane. Therefore, the effect of UV on sythesis, mass, and distribution of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e70f903bbfe9462976b1d6c9d5e36a6
https://pubmed.ncbi.nlm.nih.gov/8928731

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