Zobrazeno 1 - 10
of 10
pro vyhledávání: '"J. Magnus Fredriksson"'
Autor:
Carl-Fredrik Mandenius, Giorgio Minotti, Tina C. Stummann, Y. Jean Pierre Valentin, Robin L. Jones, J. Magnus Fredriksson, Thomas Meyer, Marina Hasiwa, Göran Duker, Y. James Kang, Mario Beilmann, Bernd J. Zünkler, Susanne Bremer, Berengere Dumotier
Publikováno v:
Cardiovascular Toxicology. 9:107-125
Cardiotoxicity is among the leading reasons for drug attrition and is therefore a core subject in non-clinical and clinical safety testing of new drugs. European Centre for the Validation of Alternative Methods held in March 2008 a workshop on “Alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a202da502ab43233d90ace4b429a4005
https://doi.org/10.1007/s12012-009-9045-3
https://doi.org/10.1007/s12012-009-9045-3
Publikováno v:
Analytical Biochemistry. 387:271-275
A novel cell-based fluorometric sensor system for toxicity monitoring is described, which uses functional spontaneously contracting cardiomyocytes (HL-1 cell line) as the biological recognition element. Based on these highly specialized cells, it has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f4db4103bc493b0b327c95c09dc16c
https://doi.org/10.1016/j.ab.2009.01.027
https://doi.org/10.1016/j.ab.2009.01.027
Autor:
Lars B. Nilsson, Göran Eklund, Stig Johan Wiklund, Göran Duker, Ahmad Al-Saffar, Tomas Forsberg, Johan Gabrielsson, Anna H. Persson, Anna Ollerstam, J. Magnus Fredriksson, Sandra A.G. Visser
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 55:35-48
Introduction: Drug-induced QT interval prolongation may lead to ventricular arrhythmias. The aim of the study was to optimize QT interval data processing to quantify drug-induced QT interval prolongation in the telemetry instrumented conscious dog mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea178a75325028559170c347f76cfad
https://doi.org/10.1016/j.vascn.2006.02.009
https://doi.org/10.1016/j.vascn.2006.02.009
Publikováno v:
Journal of Biological Chemistry. 275:13802-13811
To identify the signaling pathway that mediates the adrenergic stimulation of the expression of the gene for vascular endothelial growth factor (VEGF) during physiologically induced angiogenesis, we examined mouse brown adipocytes in primary culture.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58cc93ac63f62a23cb6223ff6df44e55
https://doi.org/10.1074/jbc.275.18.13802
https://doi.org/10.1074/jbc.275.18.13802
Autor:
Christine Batzl-Hartmann, J. Magnus Fredriksson, Petter Björquist, Sandra Coecke, Manuel J.T. Carrondo, Jörg C. Gerlach, Barbara Küppers-Munther, Fozia Noor, Josefina Edsbagge, Paula M. Alves, Katrin Zeilinger, Christophe Chesne, Carl-Fredrik Mandenius, Elmar Heinzle, Ursula Müller-Vieira, Inger Johansson, Tommy B. Andersson, Magnus Ingelman-Sundberg
Publikováno v:
Alternatives to laboratory animals : ATLA. 39(2)
Drug-induced liver injury is a common reason for drug attrition in late clinical phases, and even for post-launch withdrawals. As a consequence, there is a broad consensus in the pharmaceutical industry, and within regulatory authorities, that a sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f42b799ee7267c144a4a1cf28f0eb13
https://pubmed.ncbi.nlm.nih.gov/21639679
https://pubmed.ncbi.nlm.nih.gov/21639679
Publikováno v:
Biochemical and biophysical research communications. 337(1)
The cellular response to hypoxic stress is mainly mediated via activation of the transcription factor hypoxia-inducible factor-1alpha (HIF-1alpha). In the present study, the sympathetically controlled brown adipose tissue was used to investigate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29962bcc4b8d1661d3c1d7bd27ca8611
https://pubmed.ncbi.nlm.nih.gov/16171784
https://pubmed.ncbi.nlm.nih.gov/16171784
Publikováno v:
Scopus-Elsevier
Because of the central role of adrenergic mechanisms in the expression of crucial genes during brown adipocyte differentiation, we examined the activation (phosphorylation) of CREB (cAMP-response-element-binding protein) in mouse brown adipocytes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55344ca689617232c00156b92181e428
https://pubmed.ncbi.nlm.nih.gov/11988078
https://pubmed.ncbi.nlm.nih.gov/11988078
Autor:
Jan Nedergaard, J. Magnus Fredriksson
Publikováno v:
Experimental cell research. 274(2)
We have examined whether a qualitative switch occurs in the response of the ribonucleotide reductase (RNR) genes to the effect of the physiological cAMP-elevating agent norepinephrine (NE) during the development of brown adipocytes. Basal expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99bbfd5d5ae9b732c42d453220ab9180
https://pubmed.ncbi.nlm.nih.gov/11900481
https://pubmed.ncbi.nlm.nih.gov/11900481
Publikováno v:
The Journal of biological chemistry. 275(30)
A novel signaling pathway for mediation of beta(3)-adrenergic activation of the mitogen-activated protein kinases Erk1/2 (associated with proliferation, differentiation, and apoptosis) has recently been proposed, which implies mediation via constitut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f749614d1d2aae1d12d4b73c0e3b4aec
https://pubmed.ncbi.nlm.nih.gov/10770951
https://pubmed.ncbi.nlm.nih.gov/10770951
Publikováno v:
FEBS Letters. (25):5680-5684
To examine whether cold-induced vascular endothelial growth factor (VEGF) gene expression in brown adipose tissue involved generation of hypoxic oxygen levels by thermogenic processes, we cold-exposed wild-type mice, as well as uncoupling protein-1 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7be3ce55fb1733488321dabe9de0803