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Akademický článek

Beta bursts in the parkinsonian cortico-basal ganglia network form spatially discrete ensembles

Autor: Isaac Grennan, Nicolas Mallet, Peter J. Magill, Hayriye Cagnan, Andrew Sharott

Publikováno v: Neurobiology of Disease, Vol 201, Iss , Pp 106652- (2024)

Defining spatial synchronisation of pathological beta oscillations is important, given that many theories linking them to parkinsonian symptoms propose a reduction in the dimensionality of the coding space within and/or across cortico-basal ganglia s

Externí odkaz: https://doaj.org/article/3493040dbaec47f6af013ec8f8b6a635

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Akademický článek

Distributional coding of associative learning in discrete populations of midbrain dopamine neurons

Autor: Riccardo Avvisati, Anna-Kristin Kaufmann, Callum J. Young, Gabriella E. Portlock, Sophie Cancemi, Rui Ponte Costa, Peter J. Magill, Paul D. Dodson

Publikováno v: Cell Reports, Vol 43, Iss 4, Pp 114080- (2024)

Summary: Midbrain dopamine neurons are thought to play key roles in learning by conveying the difference between expected and actual outcomes. Recent evidence suggests diversity in dopamine signaling, yet it remains poorly understood how heterogeneou

Externí odkaz: https://doaj.org/article/756bc0140341414b838ae3a42e99d3de

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Akademický článek

DePolymerase Predictor (DePP): a machine learning tool for the targeted identification of phage depolymerases

Autor: Damian J. Magill, Timofey A. Skvortsov

Publikováno v: BMC Bioinformatics, Vol 24, Iss 1, Pp 1-11 (2023)

Abstract Biofilm production plays a clinically significant role in the pathogenicity of many bacteria, limiting our ability to apply antimicrobial agents and contributing in particular to the pathogenesis of chronic infections. Bacteriophage depolyme

Externí odkaz: https://doaj.org/article/f21524db3f7f41efb211699ff5209bde

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Akademický článek

The aperiodic exponent of subthalamic field potentials reflects excitation/inhibition balance in Parkinsonism

Autor: Christoph Wiest, Flavie Torrecillos, Alek Pogosyan, Manuel Bange, Muthuraman Muthuraman, Sergiu Groppa, Natasha Hulse, Harutomo Hasegawa, Keyoumars Ashkan, Fahd Baig, Francesca Morgante, Erlick A Pereira, Nicolas Mallet, Peter J Magill, Peter Brown, Andrew Sharott, Huiling Tan

Publikováno v: eLife, Vol 12 (2023)

Periodic features of neural time-series data, such as local field potentials (LFPs), are often quantified using power spectra. While the aperiodic exponent of spectra is typically disregarded, it is nevertheless modulated in a physiologically relevan

Externí odkaz: https://doaj.org/article/7387dc14ba204a988e5ed94e7914e603

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Akademický článek

Stimulating at the right time to recover network states in a model of the cortico-basal ganglia-thalamic circuit.

Autor: Timothy O West, Peter J Magill, Andrew Sharott, Vladimir Litvak, Simon F Farmer, Hayriye Cagnan

Publikováno v: PLoS Computational Biology, Vol 18, Iss 3, p e1009887 (2022)

Synchronization of neural oscillations is thought to facilitate communication in the brain. Neurodegenerative pathologies such as Parkinson's disease (PD) can result in synaptic reorganization of the motor circuit, leading to altered neuronal dynamic

Externí odkaz: https://doaj.org/article/84c4474a19554467833683b450b75837

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Akademický článek

GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model

Autor: Bradley M. Roberts, Natalie M. Doig, Katherine R. Brimblecombe, Emanuel F. Lopes, Ruth E. Siddorn, Sarah Threlfell, Natalie Connor-Robson, Nora Bengoa-Vergniory, Nicholas Pasternack, Richard Wade-Martins, Peter J. Magill, Stephanie J. Cragg

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)

GABA transporters expressed in the striatum may affect behaviour. Here the authors investigate the contribution of GABA transporters on astrocytes to the regulation of dopamine release in the striatum, and show decreased expression of GAT-1 and GAT-3

Externí odkaz: https://doaj.org/article/f4c24c167c97494e92ebdf24a5229496

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Akademický článek

Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility

Autor: Polina Kosillo, Natalie M. Doig, Kamran M. Ahmed, Alexander H.C.W. Agopyan-Miu, Corinna D. Wong, Lisa Conyers, Sarah Threlfell, Peter J. Magill, Helen S. Bateup

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)

Tuberous Sclerosis Complex (TSC) is a neurodevelopmental disorder caused by mutations in the TSC1 or TSC2 genes, which negatively regulate mTORC1 signalling. Here the authors selectively delete Tsc1 from dopamine neurons in mice and find impairments

Externí odkaz: https://doaj.org/article/8f206497b65e4d93a92d89d476e37c28

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