Zobrazeno 1 - 10
of 539
pro vyhledávání: '"J. Macrae"'
Autor:
Carolien Bastiaanssen, Pilar Bobadilla Ugarte, Kijun Kim, Giada Finocchio, Yanlei Feng, Todd A. Anzelon, Stephan Köstlbacher, Daniel Tamarit, Thijs J. G. Ettema, Martin Jinek, Ian J. MacRae, Chirlmin Joo, Daan C. Swarts, Fabai Wu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Argonaute proteins are the central effectors of RNA-guided RNA silencing pathways in eukaryotes, playing crucial roles in gene repression and defense against viruses and transposons. Eukaryotic Argonautes are subdivided into two clades: AGOs
Externí odkaz:
https://doaj.org/article/00119b4a7cf949e3816963ef58da50a7
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The RNA genome of the Hepatitis C Virus binds to the liver-specific miR122. Here the authors report the crystal structure of the Ago2:miR122:HCV complex showing that the viral RNA’s structural element traps the Ago2:miR-122 complex on the 5’ end
Externí odkaz:
https://doaj.org/article/d60f20e8b78f473e98b7f4aa71a57e00
Publikováno v:
FEBS Open Bio, Vol 9, Iss 6, Pp 1042-1051 (2019)
Viral suppressors of RNA silencing (VSRSs) are a diverse group of viral proteins that have evolved to disrupt eukaryotic RNA silencing pathways, thereby contributing to viral pathogenicity. The p19 protein is a VSRS that selectively binds to short in
Externí odkaz:
https://doaj.org/article/5e8d095a74aa4108b2c233abd8dbfd4e
Autor:
Timothy Wiryaman, Ian J. MacRae
Publikováno v:
Cell. 186:903-905
Autor:
Amena Arif, Shannon Bailey, Natsuko Izumi, Todd A. Anzelon, Deniz M. Ozata, Cecilia Andersson, Ildar Gainetdinov, Ian J. MacRae, Yukihide Tomari, Phillip D. Zamore
Publikováno v:
Nature. 608:618-625
Argonaute proteins use nucleic acid guides to find and bind specific DNA or RNA target sequences. Argonaute proteins have diverse biological functions and many retain their ancestral endoribonuclease activity, cleaving the phosphodiester bond between
Publikováno v:
Nature Structural & Molecular Biology.
Argonaute (AGO) proteins use small RNAs to recognize transcripts targeted for silencing in plants and animals. Many AGOs possess an endoribonuclease activity termed RNA slicing, which catalyzes rapid turnover of target RNAs. The nuclease activity of
Publikováno v:
EMBO reports.
Autor:
Todd A. Anzelon, Yao Xiao, Gabriel C. Lander, Saikat Chowdhury, Siobhan M. Hughes, Ian J. MacRae
Publikováno v:
Nature
PIWI proteins use PIWI-interacting RNAs (piRNAs) to identify and silence transposable elements and thereby maintain genome integrity between metazoan generations1. The targeting of transposable elements by PIWI has been compared to mRNA target recogn
Autor:
Duncan J, Macrae
Publikováno v:
Pediatr Crit Care Med
OBJECTIVE: Characterize the use of iNO for pediatric cardiac patients, and assess the relationship between patient characteristics before iNO initiation and outcomes following cardiac surgery. DESIGN: Observational cohort study SETTING: PICU and CICU