Zobrazeno 1 - 10
of 546
pro vyhledávání: '"J. Macrae"'
Autor:
Carolien Bastiaanssen, Pilar Bobadilla Ugarte, Kijun Kim, Giada Finocchio, Yanlei Feng, Todd A. Anzelon, Stephan Köstlbacher, Daniel Tamarit, Thijs J. G. Ettema, Martin Jinek, Ian J. MacRae, Chirlmin Joo, Daan C. Swarts, Fabai Wu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Argonaute proteins are the central effectors of RNA-guided RNA silencing pathways in eukaryotes, playing crucial roles in gene repression and defense against viruses and transposons. Eukaryotic Argonautes are subdivided into two clades: AGOs
Externí odkaz:
https://doaj.org/article/00119b4a7cf949e3816963ef58da50a7
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The RNA genome of the Hepatitis C Virus binds to the liver-specific miR122. Here the authors report the crystal structure of the Ago2:miR122:HCV complex showing that the viral RNA’s structural element traps the Ago2:miR-122 complex on the 5’ end
Externí odkaz:
https://doaj.org/article/d60f20e8b78f473e98b7f4aa71a57e00
Publikováno v:
FEBS Open Bio, Vol 9, Iss 6, Pp 1042-1051 (2019)
Viral suppressors of RNA silencing (VSRSs) are a diverse group of viral proteins that have evolved to disrupt eukaryotic RNA silencing pathways, thereby contributing to viral pathogenicity. The p19 protein is a VSRS that selectively binds to short in
Externí odkaz:
https://doaj.org/article/5e8d095a74aa4108b2c233abd8dbfd4e
Autor:
Timothy Wiryaman, Ian J. MacRae
Publikováno v:
Cell. 186:903-905
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ba8683ba739e05a89b2595f58a06871
https://doi.org/10.1016/j.cell.2023.02.003
https://doi.org/10.1016/j.cell.2023.02.003
Publikováno v:
Nature Structural & Molecular Biology.
Argonaute (AGO) proteins use small RNAs to recognize transcripts targeted for silencing in plants and animals. Many AGOs possess an endoribonuclease activity termed RNA slicing, which catalyzes rapid turnover of target RNAs. The nuclease activity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74fc1d818a8ec8f3ac47f83016045e87
https://doi.org/10.1038/s41594-023-00989-7
https://doi.org/10.1038/s41594-023-00989-7
Publikováno v:
EMBO reports.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dfa7a05e1104a078e7f80aff73ce32f
https://doi.org/10.15252/embr.202255806
https://doi.org/10.15252/embr.202255806
Akademický článek
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Autor:
Amena Arif, Shannon Bailey, Natsuko Izumi, Todd A. Anzelon, Deniz M. Ozata, Cecilia Andersson, Ildar Gainetdinov, Ian J. MacRae, Yukihide Tomari, Phillip D. Zamore
Publikováno v:
Nature. 608:618-625
Argonaute proteins use nucleic acid guides to find and bind specific DNA or RNA target sequences. Argonaute proteins have diverse biological functions and many retain their ancestral endoribonuclease activity, cleaving the phosphodiester bond between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703fb3283d992e25866ef0b761130585
https://doi.org/10.1038/s41586-022-05009-0
https://doi.org/10.1038/s41586-022-05009-0
Autor:
Jasmin Chahal, Luca FR Gebert, Hin Hark Gan, Kristin C Gunsalus, Ian J MacRae, Selena M Sagan
Publikováno v:
Proceedings, Vol 50, Iss 1, p 131 (2020)
Hepatitis C virus (HCV) is a positive-sense RNA virus that interacts with a human-liver-specific microRNA, termed miR-122. miR-122 binds to two sites in the 5' untranslated region (UTR) of the viral genome, and this interaction promotes HCV RNA accum
Externí odkaz:
https://doaj.org/article/d0f47fc2e8ad4b3583533ca6fbaf168d
Autor:
Duncan J, Macrae
Publikováno v:
Pediatr Crit Care Med
OBJECTIVE: Characterize the use of iNO for pediatric cardiac patients, and assess the relationship between patient characteristics before iNO initiation and outcomes following cardiac surgery. DESIGN: Observational cohort study SETTING: PICU and CICU
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc35a237da1903730443922449a5b56d
https://doi.org/10.1097/pcc.0000000000002928
https://doi.org/10.1097/pcc.0000000000002928