Zobrazeno 1 - 10
of 463
pro vyhledávání: '"J. Macneil"'
Autor:
Bianca M. Marcella, Briana L. Hockey, Jessica L. Braun, Kennedy C. Whitley, Mia S. Geromella, Ryan W. Baranowski, Colton J. F. Watson, Sebastian Silvera, Sophie I. Hamstra, Luc J. Wasilewicz, Robert W. E. Crozier, Amélie A. T. Marais, Kun Ho Kim, Gabsang Lee, Rene Vandenboom, Brian D. Roy, Adam J. MacNeil, Rebecca E. K. MacPherson, Val A. Fajardo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Inhibiting glycogen synthase kinase 3 (GSK3) improves muscle function, metabolism, and bone health in many diseases and conditions; however, whether GSK3 should be targeted for Duchenne muscular dystrophy (DMD), a severe muscle wasting disor
Externí odkaz:
https://doaj.org/article/713f13a5ed734888b992a697f764fc15
Autor:
Pazhanichamy Kalailingam, Khalilatul‐Hanisah Mohd‐Kahliab, SoFong Cam Ngan, Ranjith Iyappan, Evelin Melekh, Tian Lu, Gan Wei Zien, Bhargy Sharma, Tiannan Guo, Adam J MacNeil, Rebecca EK MacPherson, Evangelia Litsa Tsiani, Deborah D O'Leary, Kah Leong Lim, I Hsin Su, Yong‐Gui Gao, A Mark Richards, Raj N Kalaria, Christopher P Chen, Neil E McCarthy, Siu Kwan Sze
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 12, Pp 1-16 (2023)
Abstract Aging results from the accumulation of molecular damage that impairs normal biochemical processes. We previously reported that age‐linked damage to amino acid sequence NGR (Asn‐Gly‐Arg) results in “gain‐of‐function” conformatio
Externí odkaz:
https://doaj.org/article/0e78e068254840989c041da6a4477442
Autor:
Ryan W. Baranowski, Jessica L. Braun, Briana L. Hockey, Jenalyn L. Yumol, Mia S. Geromella, Colton J.F. Watson, Nigel Kurgan, Holt N. Messner, Kennedy C. Whitley, Adam J. MacNeil, Guillemette Gauquelin-Koch, Fabrice Bertile, William Gittings, Rene Vandenboom, Wendy E. Ward, Val A. Fajardo
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107047- (2023)
Summary: We examined the effects of ∼30 days of spaceflight on glycogen synthase kinase 3 (GSK3) content and inhibitory serine phosphorylation in murine muscle and bone samples from four separate missions (BION-M1, rodent research [RR]1, RR9, and R
Externí odkaz:
https://doaj.org/article/e4d4f424c12d421f9b505e655757ff9a
Autor:
Karen A. Patte, Terrance J. Wade, Adam J. MacNeil, Richard E. Bélanger, Markus J. Duncan, Negin Riazi, Scott T. Leatherdale
Publikováno v:
BMC Public Health, Vol 22, Iss 1, Pp 1-10 (2022)
Abstract Background Youth voice has been largely absent from deliberations regarding public health measures intended to prevent SARS-CoV-2 transmission, despite being one of the populations most impacted by school-based policies. To inform public hea
Externí odkaz:
https://doaj.org/article/00063fc9e1ca459ab7feef793a4be2c4
Autor:
Nigel Kurgan, Bradley Baranowski, Joshua Stoikos, Adam J. MacNeil, Val A. Fajardo, Rebecca E. K. MacPherson, Panagiota Klentrou
Publikováno v:
Frontiers in Physiology, Vol 13 (2023)
Introduction: It is well established that sclerostin antagonizes the anabolic Wnt signalling pathway in bone, however, its physiological role in other tissues remains less clear. This study examined the effect of a high-fat diet (HFD) on sclerostin c
Externí odkaz:
https://doaj.org/article/599ad75424c84f5491a002e9c1bbe109
Autor:
Nathaniel J. Iannarelli, Terrance J. Wade, Kylie S. Dempster, Jessy Moore, Adam J. MacNeil, Deborah D. O'Leary
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 21 (2022)
Background Adverse childhood experiences (ACEs) have been linked to increased cardiovascular disease (CVD) risk. Previous reports have suggested that accelerated biological aging—indexed by telomere length (TL) and mitochondrial DNA copy number (mt
Externí odkaz:
https://doaj.org/article/cf54d53053f44890a80f4fdaca1a1a97
Autor:
Kingston E. Wong, Terrance J. Wade, Jessy Moore, Ashley Marcellus, Danielle S. Molnar, Deborah D. O'Leary, Adam J. MacNeil
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 25, Iss , Pp 100516- (2022)
Adverse childhood experiences (ACEs) are associated with dysregulation of inflammation and cortisol. The objectives of this study were to use principal component analysis to explore the inflammatory biomarker data to create inflammation composite var
Externí odkaz:
https://doaj.org/article/15c9958434d449fda355a07b86e9f9b7
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 324:H791-H803
This is the first study to investigate the influence of adverse childhood experiences (ACEs) on left ventricular mass (LVM) and function. We identified experiencing any childhood household dysfunction was associated with lower LVM in young adults ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::065b4bf7ea7b72c9c9f0c4d010f5d5d8
https://doi.org/10.1152/ajpheart.00128.2022
https://doi.org/10.1152/ajpheart.00128.2022
Autor:
Nathaniel J. Iannarelli, Adam J. MacNeil, Kylie S. Dempster, Terrance J. Wade, Deborah D. O’Leary
Publikováno v:
Physiological Reports, Vol 9, Iss 11, Pp n/a-n/a (2021)
Abstract Central arterial stiffness is an independent predictor of cardiovascular disease. It is characterized by a marked reduction in the elastin‐collagen ratio of the arterial wall extracellular matrix (ECM), and is largely the result of degrada
Externí odkaz:
https://doaj.org/article/f7e571b881c049d0988066d3340986cb
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 13, Iss , Pp 100211- (2021)
Previous research has demonstrated that perfectionism is implicated in poorer health and earlier mortality. However, to our knowledge, research has not yet determined how individual differences in perfectionistic cognitions are related to intermediar
Externí odkaz:
https://doaj.org/article/4bb1f11cdd524af1a416a0ec89436c9e