Výsledky vyhledávání - "J. M. Wrigglesworth"

Comparison of Indomethacin and Nimesulide, a Selective Cyclooxygenase-2 Inhibitor, on Key Pathophysiologic Steps in the Pathogenesis of Nonsteroidal Anti-Inflammatory Drug Enteropathy in the Rat

Autor: Iggy Tavares, Robert J. Simpson, Ingvar Bjarnason, S Rafi, J. M. Wrigglesworth, T Mahmud, S Somasundaram, G Sigthorsson, Arne Røseth, Russell Foster, Molly Jacob

Publikováno v: Scandinavian Journal of Gastroenterology. 33:728-735

The predicted gastrointestinal tolerability of specific cyclooxygenase-2 inhibitors could be due to either a lack of 'topical' irritation and/or lack of effect on cyclooxygenase-1.Key pathophysiologic steps (in vitro and in vivo uncoupling, intestina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbaca35657f4f075520d4ff13d1fec58
https://doi.org/10.1080/00365529850171675

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Review: The Biochemical Basis of Non-Steroidal Anti-Inflammatory Drug-Induced Damage to the Gastrointestinal Tract: A Review and a Hypothesis

Autor: Ingvar Bjarnason, S Rafi, H. Hayllar, J. M. Wrigglesworth, A. J. S. Macpherson, S Somasundaram

Publikováno v: Scandinavian Journal of Gastroenterology. 30:289-299

Non-steroidal anti-inflammatory drugs (NSAIDs) are amongst the most successful group of drugs ever marketed, which demonstrates their overall efficacy. They are not, however, without side effects (...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98233dd6a624fad2e4e5d22d1a5d03e3
https://doi.org/10.3109/00365529509093280

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Uncoupling of intestinal mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of NSAID-enteropathy in the rat

Autor: S, Somasundaram, G, Sigthorsson, R J, Simpson, J, Watts, M, Jacob, I A, Tavares, S, Rafi, A, Roseth, R, Foster, A B, Price, J M, Wrigglesworth, I, Bjarnason

Publikováno v: Alimentary pharmacologytherapeutics. 14(5)

The pathogenesis of NSAID-induced gastrointestinal damage is believed to involve a nonprostaglandin dependent effect as well as prostaglandin dependent effects. One suggestion is that the nonprostaglandin mechanism involves uncoupling of mitochondria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8656038da855fef08bdcaeec5b101d5f
https://pubmed.ncbi.nlm.nih.gov/10792129

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The ferric-reducing activity of duodenal brush-border membrane vesicles is associated with a b-type haem

Autor: D J, Pountney, K B, Raja, R J, Simpson, J M, Wrigglesworth

Publikováno v: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 12(1)

Rabbit brush-border membrane vesicles possess ferricyanide reducing activity. This activity is preferentially dependent on NADH as reductant, and can be stimulated by the addition of FMN. The latency of activity observed following vesicle solubilisat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::07fb6777c483103579a7044b6a21d482
https://pubmed.ncbi.nlm.nih.gov/10420574

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Mitochondrial damage: a possible mechanism of the 'topical' phase of NSAID induced injury to the rat intestine

Autor: Ingvar Bjarnason, S Rafi, A Macpherson, Jeremy Hayllar, J. M. Wrigglesworth, M Jacob, T Mahmod, A B Price, S Somasundaram, David Scott, G Sigthorsson

Background—The “topical” effect of non-steroidal anti-inflammatory drugs (NSAIDs) seems to be an important cause of NSAID induced gastrointestinal damage.Aim—To examine the possible mechanism of the “topical” phase of damage in the small

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9aa33b5178ba39be2da821050239d45
https://europepmc.org/articles/PMC1891477/

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Cytochrome bd oxidase from Azotobacter vinelandii. Purification and quantitation of ligand binding to the oxygen reduction site

Autor: S, Jünemann, J M, Wrigglesworth

Publikováno v: The Journal of biological chemistry. 270(27)

Cytochrome bd has been purified from Azotobacter vinelandii by a new simplified procedure. The heme and total iron content has been measured, as has the number of high affinity CO and NO binding sites. Spectral changes indicate high affinity binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::355b7d569f3393ad79b27a1761840add
https://pubmed.ncbi.nlm.nih.gov/7608187

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Formation and reduction of a ‘peroxy’ intermediate of cytochrome c oxidase by hydrogen peroxide

Autor: J M Wrigglesworth

Publikováno v: Biochemical Journal. 217:715-719

In the presence of micromolar concentrations of H2O2, ferric cytochrome c oxidase forms a stable complex characterized by an increased absorption intensity at 606-607 nm with a weaker absorption band in the 560-580 nm region. Higher (millimolar) conc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7652b29db0c7dde949228fd5272e5fc6
https://doi.org/10.1042/bj2170715

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Pathways of cytochrome c oxidation by soluble and membrane-bound cytochrome aa3

Autor: B. C. Hill, Peter Nicholls, V. Hildebrandt, J. M. Wrigglesworth, F. Nicholls

Publikováno v: Canadian Journal of Biochemistry. 58:969-977

In media of low ionic strength, membraneous cytochrome c oxidase, isolated cytochrome c oxidase, and proteoliposomal cytochrome c oxidase each bind cytochrome c at two sites, one of low affinity (1 μM > Kd′ > 0.2 μM) and readily reversible and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c943955bf9542212373c6e06b598f13
https://doi.org/10.1139/o80-132

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