Zobrazeno 1 - 10 of 40 pro vyhledávání: '"J. M. WHITELEY"'
1
Antibacterial agents that inhibit two-component signal transduction systems
Autor: R. M. Goldschmidt, S. G. Johnson, D. H. Klaubert, L. E. Lawrence, B. Foleno, James A. Hoch, J. P. Demers, R. M. Kanojia, Lei Wang, R. Chen, R. Frechette, A. Donetz, L. Licata, John F. Barrett, J. M. Whiteley, Kwasi A. Ohemeng, D. J. Hlasta, MaryBeth Frosco, J. Bernstein, J. Fernandez, S. Huang, M. J. Macielag
Publikováno v: Proceedings of the National Academy of Sciences. 95:5317-5322
A class of antibacterials has been discovered that inhibits the growth of Gram-positive pathogenic bacteria. RWJ-49815, a representative of a family of hydrophobic tyramines, in addition to being a potent bactericidal Gram-positive antibacterial, inh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f5c667d49c293cae45ac2a9293f4c7
https://doi.org/10.1073/pnas.95.9.5317
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2
A Response Regulatory Protein with the Site of Phosphorylation Blocked by an Arginine Interaction: Crystal Structure of Spo0F from Bacillus subtilis
Autor: Kottayil I. Varughese, Nguyen-Huu Xuong, Madhusudan M, James A. Hoch, J Zapf, J. M. Whiteley
Publikováno v: Biochemistry. 36:12739-12745
Spo0F is a secondary messenger in the "two-component" system controlling the sporulation of Bacillus subtilis. Spo0F, like the chemotaxis protein CheY, is a single-domain protein homologous to the N-terminal activator domain of the response regulator
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3809c7c78b5ca5ecb7b6afe9db0e543
https://doi.org/10.1021/bi971276v
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3
Purification and preliminary crystallographic studies on the sporulation response regulatory phosphotransferase protein, spo0B, fromBacillus subtilis
Autor: Kottayil I. Varughese, Madhusudan, James A. Hoch, Xiao Zhen Zhou, J. M. Whiteley
Publikováno v: Proteins: Structure, Function, and Genetics. 27:597-600
The phosphotransferase protein Spo0B, a component of the sporulation signal transduction system in Bacillus subtilis was expressed from the Escherichia coli strain BL21DE3. It was purified, crystallized, and 2.25 A data measured using the synchrotron
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f448d1a6b1e0a2b7a984eb7894793b2
https://doi.org/10.1002/(sici)1097-0134(199704)27:4<597::aid-prot11>3.0.co
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4
Crystal structure of a monoclinic form of dihydropteridine reductase from rat liver
Autor: M. Skinner, David A. Matthews, Ying Su, Kottayil I. Varughese, Nguyen-Huu Xuong, J. M. Whiteley
Publikováno v: Acta Crystallographica Section D Biological Crystallography. 50:884-888
A binary complex of dihydropteridine reductase and NADH crystallizes in the space group C2, with a = 222.2, b = 46.5, c = 95.3 A and beta = 101.1 degrees. There are two dimers in the asymmetric unit. The structure was solved by molecular-replacement
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec9a4896e726cdf2ba909dbbc1dec7c
https://doi.org/10.1107/s0907444994005718
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5
Structural and mechanistic characteristics of dihydropteridine reductase: a member of the Tyr-(Xaa)3-Lys-containing family of reductases and dehydrogenases
Autor: J. M. Whiteley, P M Kiefer, Kottayil I. Varughese, Nguyen Huu Xuong, David A. Matthews
Publikováno v: Proceedings of the National Academy of Sciences. 91:5582-5586
Dihydropteridine reductase (EC 1.6.99.7) is a member of the recently identified family of proteins known as short-chain dehydrogenases. When the x-ray structure of dihydropteridine reductase is correlated with conserved amino acid sequences character
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9ddab8457068c7a28f40fcb9a05312
https://doi.org/10.1073/pnas.91.12.5582
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6
Subunit composition and domain structure of the Spo0A sporulation transcription factor of Bacillus subtilis
Autor: James A. Hoch, Z Hostomsky, J. M. Whiteley, T H Bird, Mark A. Strauch, G B Spiegelman, Ronald B. Tjalkens, J K Grimsley
Publikováno v: Journal of Biological Chemistry. 269:16977-16982
The Spo0A transcription factor is responsible for the initiation of sporulation and is active in transcription only after phosphorylation by a specific signal transduction pathway, the phosphorelay. The effect of phosphorylation on the physical prope
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1dc70298d7315af94ad76dc6307c1bea
https://doi.org/10.1016/s0021-9258(19)89485-1
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9
Characterization and nucleotide binding properties of a mutant dihydropteridine reductase containing an aspartate 37-isoleucine replacement
Autor: Tom Bray, M. Skinner, Kottayil I. Varughese, Nguyen-Huu Xuong, D.A. Matthews, James A. Hoch, J. M. Whiteley, C E Grimshaw
Publikováno v: Journal of Biological Chemistry. 267:15334-15339
Kinetic constants for the interaction of NADH and NADPH with native rat dihydropteridine reductase (DHPR) and an Escherichia coli expressed mutant (D-37-I) have been determined. Comparison of kcat and Km values measured employing quinonoid 6,7-dimeth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a16f0f303bcfbcea3b6cb7b0e2cf44a
https://doi.org/10.1016/s0021-9258(19)49538-0
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