Výsledky vyhledávání - "J. M. Shipley"

Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice

Autor: Steven D. Shapiro, J M Shipley, Robin L. Wesselschmidt, Timothy J. Ley, D K Kobayashi

Publikováno v: Proceedings of the National Academy of Sciences. 93:3942-3946

Macrophages secrete a variety of proteinases that are thought to participate in remodeling of the extracellular matrix associated with inflammatory processes. We have eliminated expression of the macrophage metalloelastase (MME) gene by targeted disr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac7f5cfa30c145b0c761c4c13a59df39
https://doi.org/10.1073/pnas.93.9.3942

Zobrazit plný text záznamu

Contribution of the C-terminal domain of metalloproteinases to binding by tissue inhibitor of metalloproteinases. C-terminal truncated stromelysin and matrilysin exhibit equally compromised binding affinities as compared to full-length stromelysin

Autor: Qi Zhuang Ye, M. C. Conroy, H. G. Welgus, J. M. Shipley, C. J. Fliszar, Vijaykumar M. Baragi

Publikováno v: Journal of Biological Chemistry. 269:12692-12697

In this study, we have used high resolution gel-filtration chromatography and measurements of Ki to compare the capacity of full-length native stromelysin, C-terminal truncated stromelysin (Phe100-Pro273), and matrilysin (the only metalloproteinase s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55e3afd34c5f098de74c962773aa1c75
https://doi.org/10.1016/s0021-9258(18)99931-x

Zobrazit plný text záznamu

Chromosome-mediated gene thnsfer

Autor: J M, Shipley, D, Sheer

Publikováno v: Methods in molecular biology (Clifton, N.J.). 7

McBride and Ozer (1) were the first to show that purified metaphase chromosomes could act as vectors in transferring genetic information into mammalian cells. This technique, termed chromosome-mediated gene transfer (CMGT), involves the transfer of s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f378e852229c35b8b3f2829f0e06f2d6
https://pubmed.ncbi.nlm.nih.gov/21416351

Zobrazit plný text záznamu

The role of glycosylation and phosphorylation in the expression of active human beta-glucuronidase

Autor: Jeffrey H. Grubb, William S. Sly, J M Shipley

Publikováno v: Journal of Biological Chemistry. 268:12193-12198

Phosphorylation of mannose residues on N-linked oligosaccharide side chains of lysosomal enzymes targets them to lysosomes. We used site-directed mutagenesis to observe the effect of eliminating selective glycosylation sites from human beta-glucuroni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c169810f4be6cda14d24354cd67cb4a9
https://doi.org/10.1016/s0021-9258(19)50325-8

Zobrazit plný text záznamu

Microfibril-associated protein 4 binds to surfactant protein A (SP-A) and colocalizes with SP-A in the extracellular matrix of the lung

Autor: Francis X. McCormack, Uffe Holmskov, Patrick W. Hein, Ida Tornøe, F. Brasch, Theresa Thomsen, Karsten Skjødt, Nades Palaniyar, Ole John Nielsen, W. Steinhilber, J. M. Shipley, Anders Schlosser

Publikováno v: Schlosser, A, Thomsen, T H, Shipley, J M, Hein, P W, Brasch, F, Tornøe, I, Nielsen, O, Skjødt, K, Palaniyar, N, Steinhilber, W, McCormack, F X & Holmskov, U 2006, ' Microfibril-associated Protein 4 Binds to Surfactant Protein A (SP-A) and Colocalizes with SP-A in the Extracellular Matrix of the Lung ', Scandinavian Journal of Immunology, vol. 64, no. 2, pp. 104-116 .
University of Southern Denmark

Udgivelsesdato: august 2006 Pulmonary surfactant protein A (SP-A) is an oligomeric collectin that recognizes lipid and carbohydrate moieties present on broad range of micro-organisms, and mediates microbial lysis and clearance. SP-A also modulates mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01bcddf8ddc39a491c1e9ff0ab1f4d2
https://pubmed.ncbi.nlm.nih.gov/16867155

Zobrazit plný text záznamu

Developmental Expression of Latent Transforming Growth Factor β Binding Protein 2 and Its Requirement Early in Mouse Development

Autor: Steven D. Shapiro, F Segade, Mary Baumann, J M Shipley, E Maus, Robert P. Mecham, Ronald McCarthy, J. Rosenbloom, Cheryl Frankfater, J Bonadio

Latent transforming growth factor beta (TGF-beta) binding protein 2 (LTBP-2) is an integral component of elastin-containing microfibrils. We studied the expression of LTBP-2 in the developing mouse and rat by in situ hybridization, using tropoelastin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450b16763f73e40ab6866c288d248b59
https://europepmc.org/articles/PMC85939/

Zobrazit plný text záznamu

Comparative genomic hybridization analysis of lobular carcinoma in situ and atypical lobular hyperplasia and potential roles for gains and losses of genetic material in breast neoplasia

Autor: Y J, Lu, P, Osin, S R, Lakhani, S, Di Palma, B A, Gusterson, J M, Shipley

Publikováno v: Cancer research. 58(20)

Lobular carcinoma in situ (LCIS) and atypical lobular hyperplasia (ALH) of the breast are cytologically similar breast lesions that reportedly carry different relative risks of subsequent development of invasive carcinoma. They are frequently multifo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::06108405f8079f658841d5731b7aa4f5
https://pubmed.ncbi.nlm.nih.gov/9788628

Zobrazit plný text záznamu

Interphase fluorescence in situ hybridization detection of t(2;13)(q35;q14) in alveolar rhabdomyosarcoma--a diagnostic tool in minimally invasive biopsies

Autor: A P, McManus, M A, O'Reilly, K P, Jones, B A, Gusterson, C D, Mitchell, C R, Pinkerton, J M, Shipley

Publikováno v: The Journal of pathology. 178(4)

The identification of t(2;13)(q35;q14) is a useful aid in the accurate diagnosis of rhabdomyosarcoma, distinguishing it from other small round cell tumours and supporting the distinction between alveolar and embryonal forms. Cytogenetic analysis is d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c36e537a9983cbc9eed11a70ead71745
https://pubmed.ncbi.nlm.nih.gov/8691319

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání