Výsledky vyhledávání - "J. M. Schaeffer"

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Distinct effects of the antiestrogen Faslodex on the stability of estrogen receptors-alpha and -beta in the breast cancer cell line MCF-7

Autor: Edward C. Hayes, Hilary A. Wilkinson, J M Schaeffer, Sudha W. Mitra, T Chang, Norbert T. Peekhaus, S P Rohrer

Publikováno v: Journal of molecular endocrinology. 32(3)

The effects of estrogen receptor (ER) ligands on the stability and transcriptional activity of ERbeta in the breast cancer cell lines MCF-7 and HeLa were examined. We found that ERbeta was degraded in the presence of 17beta-estradiol. Tamoxifen and F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89791fa8fae018e955e0dfe881c3e701
https://pubmed.ncbi.nlm.nih.gov/15171727

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Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor

Autor: G R, Dawson, K A, Wafford, A, Smith, G R, Marshall, P J, Bayley, J M, Schaeffer, P T, Meinke, R M, McKernan

Publikováno v: The Journal of pharmacology and experimental therapeutics. 295(3)

Twenty-five avermectin analogs were assessed in a mouse seizure model. The ED(50) against pentylenetetrazole-induced tonic seizures ranged from 0.48 mg/kg (L-676,893) to160 mg/kg (L-685,869) cf. 0. 26 mg/kg for diazepam. Although avermectins are with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4ec348d341a308ac44378ab359d4b03a
https://pubmed.ncbi.nlm.nih.gov/11082440

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Picrotoxin blockade of invertebrate glutamate-gated chloride channels: subunit dependence and evidence for binding within the pore

Autor: A, Etter, D F, Cully, K K, Liu, B, Reiss, D K, Vassilatis, J M, Schaeffer, J P, Arena

Publikováno v: Journal of neurochemistry. 72(1)

Glutamate-gated chloride channels have been described in nematodes, insects, crustaceans, and mollusks. Subunits from the nematode and insect channels have been cloned and are phylogenetically related to the GABA and glycine ligand-gated chloride cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9b084c40733edc4f7d9d669088c1a484
https://pubmed.ncbi.nlm.nih.gov/9886084

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Genetic and biochemical evidence for a novel avermectin-sensitive chloride channel in Caenorhabditis elegans. Isolation and characterization

Autor: D K, Vassilatis, J P, Arena, R H, Plasterk, H A, Wilkinson, J M, Schaeffer, D F, Cully, L H, Van der Ploeg

Publikováno v: The Journal of biological chemistry. 272(52)

Avermectins are a class of macrocyclic lactones that is widely used in crop protection and to treat helminth infections in man and animals. Two complementary DNAs (GluClalpha and GluClbeta) encoding chloride channels that are gated by avermectin and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::986360eda0159359f1235993681de6d1
https://pubmed.ncbi.nlm.nih.gov/9407104

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The mechanism of action of avermectins in Caenorhabditis elegans: correlation between activation of glutamate-sensitive chloride current, membrane binding, and biological activity

Autor: J P, Arena, K K, Liu, P S, Paress, E G, Frazier, D F, Cully, H, Mrozik, J M, Schaeffer

Publikováno v: The Journal of parasitology. 81(2)

Xenopus laevis oocytes were injected with mRNA isolated from the free-living nematode Caenorhabditis elegans and the activation and potentiation of a glutamate-sensitive chloride current by a series of avermectin analogs and milbemycin D were determi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::672dec1d88b837e8de152b29ba7c28dd
https://pubmed.ncbi.nlm.nih.gov/7707209

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Ivermectin binding sites in sensitive and resistant Haemonchus contortus

Autor: S P, Rohrer, E T, Birzin, C H, Eary, J M, Schaeffer, W L, Shoop

Publikováno v: The Journal of parasitology. 80(3)

Membranes from both ivermectin-sensitive and -resistant Haemonchus contortus L3 larvae were examined for the presence of high affinity [3H]ivermectin binding sites. Both tissue preparations displayed high affinity drug binding sites (Kd = 0.13 nM). R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d0e16100699298b8fca489d6f8ef9817
https://pubmed.ncbi.nlm.nih.gov/8195956

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[3H]paraherquamide binding to Caenorhabditis elegans. Studies on a potent new anthelmintic agent

Autor: J M, Schaeffer, T A, Blizzard, J, Ondeyka, R, Goegelman, P J, Sinclair, H, Mrozik

Publikováno v: Biochemical pharmacology. 43(4)

Paraherquamide was identified recently as a potent anthelmintic agent. In this paper we describe the identification and characterization of a specific, high-affinity paraherquamide binding site in a membrane preparation isolated from the free-living

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7d18dccae00189edec203ef679b9429d
https://pubmed.ncbi.nlm.nih.gov/1540222

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The effect of protein binding on ivermectin uptake by bovine brain microvessel endothelial cells

Autor: J. M. Schaeffer, S. R. Knaub, F. L. Guillot, K. L. Audus

Publikováno v: Veterinary research communications. 16(5)

The effect of albumin binding on ivermectin uptake and transfer across the endothelial component of the blood-brain barrier (BBB) was determined with an in vitro model comprised of bovine brain microvessel endothelial cell (BMEC) monolayers. Cellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169850f2f8e5308dbcde2a5807504255
https://pubmed.ncbi.nlm.nih.gov/1494861

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