Zobrazeno 1 - 10 of 49 pro vyhledávání: '"J. M. Sayer"'
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Dose-dependent differences in the profile of mutations induced by an ultimate carcinogen from benzo[a]pyrene
Autor: Bradley D. Preston, N. Bhachech, Xiao Xing Cui, C.-Q. Wong, H Yagi, D M Jerina, Richard L. Chang, S J Wei, J M Sayer, E. Hennig
Publikováno v: Proceedings of the National Academy of Sciences. 88:11227-11230
Mutations in the coding region of the hypoxanthine (guanine) phosphoribosyltransferase (HPRT) gene of Chinese hamster V-79 cells were examined after exposure of the cells to a high cytotoxic dose (0.48 microM; 35% survival) and a low noncytotoxic dos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477734e7af54247687227e4435cb3fc2
https://doi.org/10.1073/pnas.88.24.11227
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5
Barium enema or colonoscopy for the investigation of iron deficiency anaemia?
Autor: J M, Sayer, M T, Donnelly, A S, McIntyre, J R, Barton, M J, Grundman, F R, Vicary, R G, Long
Publikováno v: Journal of the Royal College of Physicians of London. 33(6)
To determine whether double contrast barium enema is adequate for excluding carcinoma of the colon in patients with iron deficiency anaemia.Prospective audit.One hundred and twenty-three patients with iron deficiency anaemia.All patients had upper in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e7d050cf794593b5613d31d9335e3a4c
https://pubmed.ncbi.nlm.nih.gov/10633332
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6
The ratio of deoxyadenosine to deoxyguanosine adducts formed by (+)-(7R,8S,9S,10R)-7,8-dihydroxy-9,10-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene in purified calf thymus DNA and DNA in V-79 cells is independent of dose
Autor: Allan H. Conney, D. M. Jerina, S.-J. C. Wei, Richard L. Chang, Xiao Xing Cui, J. M. Sayer, N. Dandamudi, K. A. Merkler, C.-Q. Wong, Yao-Ping Lu
Publikováno v: International journal of oncology. 14(3)
The hypothesis that the decrease in the proportion of mutations at AT base pairs in Chinese hamster V-79 cells treated with increasing doses of (+)-(R,S,S,R)-benzo[a]pyrene diol epoxide ((+)-BPDE) is due to saturation of Ahot spotsfor adduct formatio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::440fd97e7e57b8a488e2ae2fa8fcbad0
https://pubmed.ncbi.nlm.nih.gov/10024684
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7
Stereospecific differences in repair by human cell extracts of synthesized oligonucleotides containing trans-opened 7,8,9, 10-tetrahydrobenzo[a]pyrene 7,8-diol 9,10-epoxide N2-dG adduct stereoisomers located within the human K-ras codon 12 sequence
Autor: L, Custer, B, Zajc, J M, Sayer, C, Cullinane, D R, Phillips, A M, Cheh, D M, Jerina, V A, Bohr, S J, Mazur
Publikováno v: Biochemistry. 38(2)
The potent environmental carcinogen benzo[a]pyrene (BaP), following enzymatic activation to enantiomeric pairs of bay-region 7,8-diol 9, 10-epoxides (the benzylic 7-hydroxyl group and epoxide oxygen are cis for DE-1 diastereomers and trans for DE-2 d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1d7114e98684fd2d08d9d7a570e6caa7
https://pubmed.ncbi.nlm.nih.gov/9888796
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9
Covalent bonding of bay-region diol epoxides to nucleic acids
Autor: D M, Jerina, A, Chadha, A M, Cheh, M E, Schurdak, A W, Wood, J M, Sayer
Publikováno v: Advances in experimental medicine and biology. 283
Although the solution chemistry of diol epoxides is now fairly well understood, a great deal remains to be elucidated regarding their reaction in the presence of DNA. Not only DNA but also small molecules are capable of sequestering diol epoxides in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0cc3c4358c4ddcf960954b9fdbe3a54f
https://pubmed.ncbi.nlm.nih.gov/2069024
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