Výsledky vyhledávání - "J. M. Nerbonne"

Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability

Autor: D J, Speca, G, Ogata, D, Mandikian, H I, Bishop, S W, Wiler, K, Eum, H Jürgen, Wenzel, E T, Doisy, L, Matt, K L, Campi, M S, Golub, J M, Nerbonne, J W, Hell, B C, Trainor, J T, Sack, P A, Schwartzkroin, J S, Trimmer

Publikováno v: Genes, brain, and behavior. 13(4)

The Kv2.1 delayed rectifier potassium channel exhibits high-level expression in both principal and inhibitory neurons throughout the central nervous system, including prominent expression in hippocampal neurons. Studies of in vitro preparations sugge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d10b5dd074baf6b538290935d57d20ef
https://pubmed.ncbi.nlm.nih.gov/24494598

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Calcium-independent depolarization-activated potassium currents in superior colliculus-projecting rat visual cortical neurons

Autor: J. L. Albert, J. M. Nerbonne

Publikováno v: Journal of Neurophysiology. 73:2163-2178

1. K+ conductances were characterized in isolated, identified superior colliculus-projecting (SCP) rat visual cortical neurons. SCP neurons were identified in vitro under epifluorescence illumination after in vivo retrograde labeling with rhodamine-l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c442d895ef8b69f02b9180e4806c18bb
https://doi.org/10.1152/jn.1995.73.6.2163

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Functional consequences of elimination of i(to,f) and i(to,s): early afterdepolarizations, atrioventricular block, and ventricular arrhythmias in mice lacking Kv1.4 and expressing a dominant-negative Kv4 alpha subunit

Autor: W, Guo, H, Li, B, London, J M, Nerbonne

Publikováno v: Circulation research. 87(1)

It was recently reported that the slow transient outward K(+) current, I(to, s), that is evident in mouse left ventricular septal cells is eliminated in mice with a targeted deletion of the Kv1.4 gene (Kv1.4(-/-)). The rapidly inactivating transient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d053110118a7bc875906c6a99928d5ba
https://pubmed.ncbi.nlm.nih.gov/10884364

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Expression of distinct ERG proteins in rat, mouse, and human heart. Relation to functional I(Kr) channels

Autor: A L, Pond, B K, Scheve, A T, Benedict, K, Petrecca, D R, Van Wagoner, A, Shrier, J M, Nerbonne

Publikováno v: The Journal of biological chemistry. 275(8)

One form of inherited long QT syndrome, LQT2, results from mutations in HERG1, the human ether-a-go-go-related gene, which encodes a voltage-gated K(+) channel alpha subunit. Heterologous expression of HERG1 gives rise to K(+) currents that are simil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b759f38f314c4d7ac21f6433aadc27a6
https://pubmed.ncbi.nlm.nih.gov/10681594

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Regulation of voltage-gated K+ channel expression in the developing mammalian myocardium

Autor: J M, Nerbonne

Publikováno v: Journal of neurobiology. 37(1)

As in neurons, depolarization-activated, Ca2+-independent outward K+ currents play prominent roles in shaping the waveforms of action potentials in myocardial cells. Several different types of voltage-gated K+ currents that contribute to the distinct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cfd419347b6abff1ff756db0d785d2cf
https://pubmed.ncbi.nlm.nih.gov/9777731

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Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons

Autor: G, Bu, E A, Maksymovitch, J M, Nerbonne, A L, Schwartz

Publikováno v: The Journal of biological chemistry. 269(28)

The low density lipoprotein receptor-related protein (LRP) is a multifunctional cell surface receptor, expressed in liver, that binds with high affinity and endocytoses several structurally and functionally distinct ligands, including apolipoprotein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::61e59204389e7df171255203aa54c812
https://pubmed.ncbi.nlm.nih.gov/7518435

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cis-3,3'-Bis-[alpha-(trimethylammonium)methyl]azobenzene (cis-Bis-Q). Purification and properties at acetylcholine receptors of Electrophorus electroplaques

Autor: J M, Nerbonne, R E, Sheridan, L D, Chabala, H A, Lester

Publikováno v: Molecular pharmacology. 23(2)

The cis and trans isomers of the photoisomerizable compound, 3,3'-bis-[alpha-(trimethylammonium)methyl]azobenzene (Bis-Q), were purified by high-performance liquid chromatography using the ion-pair partitioning technique on a reverse-phase column. So

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3a8db80c5970696a756d8427800cbdfa
https://pubmed.ncbi.nlm.nih.gov/6835200

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