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pro vyhledávání: '"J. M. McMillan"'
Publikováno v:
Case Reports in Endocrinology, Vol 2018 (2018)
Background. Classical Wolfram syndrome (WS) is a rare autosomal recessive disorder caused by mutations in WFS1, a gene implicated in endoplasmic reticulum (ER) and mitochondrial function. WS is characterized by insulin-requiring diabetes mellitus and
Externí odkaz:
https://doaj.org/article/dad2381656904fb99c057c9cf9bd4217
Autor:
J. M. McMillan, B. R. Sutherland
Publikováno v:
Nonlinear Processes in Geophysics, Vol 17, Iss 5, Pp 443-453 (2010)
The generation and evolution of solitary waves by intrusive gravity currents in an approximate two-layer fluid with equal upper- and lower-layer depths is examined in a cylindrical geometry by way of theory and numerical simulations. The study is lim
Externí odkaz:
https://doaj.org/article/0877136878364424b7bc65693f3e54aa
Publikováno v:
Case Reports in Endocrinology, Vol 2018 (2018)
Case Reports in Endocrinology
Case Reports in Endocrinology
Background.Classical Wolfram syndrome (WS) is a rare autosomal recessive disorder caused by mutations inWFS1,a gene implicated in endoplasmic reticulum (ER) and mitochondrial function. WS is characterized by insulin-requiring diabetes mellitus and op
Publikováno v:
Proceedings of the Institution of Mechanical Engineers, Part A: Journal of Power and Energy. 222:493-507
The tidal power available for electricity generation from in-stream turbines placed in the Minas Passage of the Bay of Fundy is examined. A previously derived theory is adapted to model the effect of turbine drag on the flow through the Minas Passage
Publikováno v:
Journal of Pharmacy and Pharmacology. 57:599-605
S-adenosyl-l-methionine (SAMe) is an endogenous molecule that is known to be protective against hepatotoxic injury. Although oral SAMe appears to be absorbed across the intestinal mucosa, its systemic bioavailability is low. The reason for this is un
Publikováno v:
Cell Biology and Toxicology. 16:257-273
Dichloroacetate (DCA) and trichloroacetate (TCA) are metabolites of the environmental contaminant trichloroethylene (TCE) that are thought to be responsible for its hepatocarcinogenicity in B6C3F1 mice. TCA and DCA induce peroxisomal proliferation an
Publikováno v:
Biochemical Pharmacology. 46:1661-1664
Metabolism of the anticancer drug taxol was investigated in freshly isolated rat hepatocytes. Two main metabolites were separated by reversed-phase HPLC and shown by tandem mass spectrometry to be monohydroxylated metabolites. Kinetic studies reveale
Autor:
J M, McMILLAN
Publikováno v:
The Journal of the Oklahoma State Medical Association. 39
Autor:
J M, McMillan
Publikováno v:
Journal of biochemical and molecular toxicology. 13(3-4)
Galactosamine hepatotoxicity in vivo has long been associated with rapid and extensive depletion of hepatic uridine nucleotides. Depletion of uridine nucleotides is considered to be causal in the toxicity, as evidenced by the protective effect of uri
Galactosamine decreases nitric oxide formation in cultured rat hepatocytes: mechanism of suppression
Autor:
J M, McMillan
Publikováno v:
Journal of biochemical and molecular toxicology. 13(3-4)
We have shown that nitric oxide production is dramatically decreased in rat primary hepatocyte cultures exposed to galactosamine. Cotreatment of the cells with uridine, which is known to prevent cytotoxicity, was found to also attenuate NO loss. In t