Suppressor macrophages in African trypanosomiasis inhibit T cell proliferative responses by nitric oxide and prostaglandins

Autor: K W Schleifer, J M Mansfield

Publikováno v: The Journal of Immunology. 151:5492-5503

Suppression of host T cell responses is one of the hallmarks of infection with the African trypanosomes. The cellular basis for immunosuppression includes the generation of suppressor macrophages that down-regulate T cell proliferative but not necess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e5d6ceffceee988121661922a1ea2b3
https://doi.org/10.4049/jimmunol.151.10.5492

Regulation of B cell responses to the variant surface glycoprotein molecule in trypanosomiasis. II. Down-regulation of idiotype expression is associated with the appearance of lymphocytes expressing antiidiotypic receptors

Autor: C M Theodos, J M Mansfield

Publikováno v: The Journal of Immunology. 144:4022-4029

The current study examines the idiotypic expression and regulation of variant surface glycoprotein (VSG)-specific B cell responses during African trypanosomiasis. Utilizing competitive inhibition RIA analysis, we detected antibodies in the serum of B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7425e3fc9d5767c37c7421c2b1150878
https://doi.org/10.4049/jimmunol.144.10.4022

Characterization of a relatively rare class B, type 2 trypanosome variant surface glycoprotein gene

Autor: L R, Schopf, J M, Mansfield

Publikováno v: The Journal of parasitology. 84(2)

The variant surface glycoprotein (VSG) gene of Trypanosoma brucei rhodesiense LouTat 1.5, a defined African trypanosome variant antigenic type, was cloned and sequenced. Southern blot analysis revealed 2 DNA restriction fragments in both VSG 1.5 expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b27115240314e5e1dff157e35cabb8d1
https://pubmed.ncbi.nlm.nih.gov/9576500

Cytoskeleton-associated antigens from African trypanosomes are recognized by self-reactive antibodies of uninfected mice

Autor: J. M. Mansfield, E. Detmer, M. Imboden, Thomas Seebeck, Norbert Müller

Publikováno v: Müller, N.; Imboden, M.; Detmer, E.; Mansfield, J. M.; Seebeck, T. (1993). Cytoskeleton-associated antigens from African trypanosomes are recognized by self-reactive antibodies of uninfected mice. Parasitology, 107(4), pp. 411-417. Cambridge University Press 10.1017/S0031182000067767

SUMMARYSerum from uninfected mice of different strains, as well as from germ-free animals, contains antibodies which react specifically with at least two trypanosomal proteins, I/6 and MARP1. These antibody populations are highly specific for the res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f854b2dba6f013d53d3c6991f5db4ed3
https://pubmed.ncbi.nlm.nih.gov/7506406

Regulation of B cell responses to the variant surface glycoprotein (VSG) molecule in trypanosomiasis. I. Epitope specificity and idiotypic profile of monoclonal antibodies to the VSG of Trypanosoma brucei rhodesiense

Autor: C M, Theodos, D M, Reinitz, J M, Mansfield

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 144(10)

Regulatory mechanisms governing B cell responses to the trypanosome variant surface glycoprotein (VSG) molecule currently are being studied. As a fundamental basis for examining such regulation, the epitope specificities and idiotypic profiles of mur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dee355f7d751b78790c63c5b1c351562
https://pubmed.ncbi.nlm.nih.gov/1692071