Zobrazeno 1 - 10 of 20 pro vyhledávání: '"J. M. Jaffe"'
2
Modification of Clinical Presentation of Prostate Tumors by a Novel Genetic Variant in CYP3A4
Autor: T R, Rebbeck, J M, Jaffe, A H, Walker, A J, Wein, S B, Malkowicz
Publikováno v: JNCI: Journal of the National Cancer Institute. 90:1225-1229
Pathways involved in androgen metabolism have been implicated in the etiology of prostate cancer. The goal of this study was to evaluate the effect of CYP3A4, a gene associated with the oxidative deactivation of testosterone, on the clinical presenta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06592cba27b99aa438807d491e1c3e7
https://doi.org/10.1093/jnci/90.16.1225
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3
Association of SRD5A2 genotype and pathological characteristics of prostate tumors
Autor: J M, Jaffe, S B, Malkowicz, A H, Walker, S, MacBride, R, Peschel, J, Tomaszewski, K, Van Arsdalen, A J, Wein, T R, Rebbeck
Publikováno v: Cancer research. 60(6)
The enzyme product of SRD5A2, 5alpha-reductase type II, is responsible for converting testosterone to the more metabolically active dihydrotestosterone. Therefore, SRDSA2 may be involved in the development or growth of prostate tumors. To examine the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b504f240d78b90a12999adc4a716b833
https://pubmed.ncbi.nlm.nih.gov/10749132
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4
Glutathione S-transferase-mu (GSTM1) and -theta (GSTT1) genotypes in the etiology of prostate cancer
Autor: T R, Rebbeck, A H, Walker, J M, Jaffe, D L, White, A J, Wein, S B, Malkowicz
Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 8(4 Pt 1)
The glutathione S-transferases (GSTs) are involved in the metabolism of numerous potential prostate carcinogens. Common homozygous germ-line deletions exist in the genes that encode GST-mu (GSTM1) and GST-theta (GSTT1) and preclude enzyme expression.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::50928222cb63c30bae686f00b08d809b
https://pubmed.ncbi.nlm.nih.gov/10207629
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6
Bioavailability of isradipine in young and old rats: Effect of mode of administration
Autor: A. E. Hassell, J. M. Jaffe, H. F. Schran, Francis L. S. Tse
Publikováno v: Journal of Pharmacy and Pharmacology. 41:657-660
The bioavailability of isradipine has been examined in 7-and 52-week-old rats after oral (12·5 mg kg−1) or intravenous (2·5 mg kg−1) doses as a solution and administration of various doses (1·8–85·5 mg kg−1) in the diet. Serial plasma sam
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07647ce28571473b8ddbbab9cf5fc91c
https://doi.org/10.1111/j.2042-7158.1989.tb06554.x
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7
Pharmacokinetics of PN 200-110 (isradipine), a new calcium antagonist, after oral administration in man
Autor: F. L. S. Tse, J. M. Jaffe
Publikováno v: European Journal of Clinical Pharmacology. 32:361-365
The pharmacokinetics of PN 200-110 (isradipine), a new calcium channel blocking agent, have been studied in 18 normal male volunteers who received orally a single 5-mg dose, a single 20-mg dose, or repeated administration of 5 mg every 8 h for 13 dos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8a8426b044d24c68654aff75a4e0b7
https://doi.org/10.1007/bf00543970
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9
Influence of high-fat meal on the absorption of a silicon — containing amide, an inhibitor of acyl — coa: Cholesterol acyltransferase, in man
Autor: J. M. Jaffe, F. L. S. Tse
Publikováno v: Biopharmaceutics & Drug Disposition. 9:201-210
The pharmacokinetics of 3-(decyldimethylsilyl)-N-[2-(4-methylphenyl)-1- phenylethyl] propanamide (DMPP), an inhibitor of acyl-CoA: cholesterol acyltransferase, have been examined in 18 healthy male volunteers who received an oral dose of either 14C-D
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d0b328434f059c1a2dbdfdda32a048
https://doi.org/10.1002/bod.2510090208
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10
Pharmacokinetics and metabolism of α-[(dimethylamino)methyl]-2-(3-ethyl-5-methyl-4-isoxazolyl)-1H-indole-3-methanol, a hypoglycemic agent, in man
Autor: Francis L. S. Tse, J. M. Jaffe, J. G. Dain, B. A. Orwig
Publikováno v: Xenobiotica. 17:1259-1267
1. The pharmacokinetics and metabolism of alpha-[(dimethylamino)methyl]-2-(3-ethyl-5-methyl-4-isoxazolyl) -1H-[3-14C]indole-3-methanol, a new hypoglycemic agent, have been studied in 15 healthy male volunteers who received an oral dose of 50 or 200 m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5d3746a1f9849f53d0ae4d62f43441
https://doi.org/10.3109/00498258709167417
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