Výsledky vyhledávání - "J. M. Halasy"

Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro

Autor: P. J. Masarachia, Steven P. Luckman, D. E. Hughes, Roslin Russell, A. A. Reszka, Gideon A. Rodan, J. M. Halasy, Michael J. Rogers, John E. Fisher, Gregg Wesolowski

Publikováno v: Proceedings of the National Academy of Sciences. 96:133-138

Nitrogen-containing bisphosphonates were shown to cause macrophage apoptosis by inhibiting enzymes in the biosynthetic pathway leading from mevalonate to cholesterol. This study suggests that, in osteoclasts, geranylgeranyl diphosphate, the substrate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a796e883d896cd436568db266dcfaf81
https://doi.org/10.1073/pnas.96.1.133

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Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase

Autor: A A, Reszka, J M, Halasy-Nagy, P J, Masarachia, G A, Rodan

Publikováno v: The Journal of biological chemistry. 274(49)

Bisphosphonates (BPs) include potent inhibitors of bone resorption used to treat osteoporosis and other bone diseases. BPs directly or indirectly induce apoptosis in osteoclasts, the bone resorbing cells, and this may play a role in inhibition of bon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f38a82e35698339c63b6aae93b3529dc
https://pubmed.ncbi.nlm.nih.gov/10574973

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