Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase

Autor: A A, Reszka, J M, Halasy-Nagy, P J, Masarachia, G A, Rodan

Publikováno v: The Journal of biological chemistry. 274(49)

Bisphosphonates (BPs) include potent inhibitors of bone resorption used to treat osteoporosis and other bone diseases. BPs directly or indirectly induce apoptosis in osteoclasts, the bone resorbing cells, and this may play a role in inhibition of bon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f38a82e35698339c63b6aae93b3529dc
https://pubmed.ncbi.nlm.nih.gov/10574973

Harnessing Macromolecular Chemistry to Design Hydrogel Micro- and Macro-Environments.

Autor: Soliman BG; School of Materials Science and Engineering, University of New South Wales, Sydney, 2052, Australia., Longoni A; Department of Orthopedics, University Medical Center Utrecht, Utrecht, 3584CX, The Netherlands., Major GS; Department of Orthopedic Surgery and Musculoskeletal Medicine, University of Otago, Christchurch, 8011, New Zealand., Lindberg GCJ; Phil and Penny Knight Campus for Accelerating Scientific Impact Department of Bioengineering, University of Oregon, Eugene, OR, 97403, USA., Choi YS; School of Human Sciences, The University of Western Australia, Perth, 6009, Australia., Zhang YS; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02115, USA., Woodfield TBF; Department of Orthopedic Surgery and Musculoskeletal Medicine, University of Otago, Christchurch, 8011, New Zealand., Lim KS; Department of Orthopedic Surgery and Musculoskeletal Medicine, University of Otago, Christchurch, 8011, New Zealand.; School of Medical Sciences, University of Sydney, Sydney, 2006, Australia.; Charles Perkins Centre, University of Sydney, Sydney, 2006, Australia.

Publikováno v: Macromolecular bioscience [Macromol Biosci] 2024 May; Vol. 24 (5), pp. e2300457. Date of Electronic Publication: 2023 Dec 20.

pH-Sensitive nanocarrier assisted delivery of adenosine to treat osteoporotic bone loss.

Autor: Newman, Hunter, Hoque, Jiaul, Shih, Yu-Ru V., Marushack, Gabrielle, Ko, Unghyeon, Gonzales, Gavin, Varghese, Shyni

Publikováno v: Biomaterials Science (2047-4830); 9/21/2022, Vol. 10 Issue 18, p5340-5355, 16p

In Vitro Osteogenesis of Synovium Mesenchymal Cells Induced by Controlled Release of Alendronate and Dexamethasone from a Sintered Microspherical Scaffold.

Autor: Yingjun Wang^1,2 imwangyj@scut.edu.cn, Xuetao Shi^1,3, Li Ren^1,2, Yongchang Yao³, Dong-An Wang^2,3

Publikováno v: Journal of Biomaterials Science -- Polymer Edition. May2010, Vol. 21 Issue 8/9, p1227-1238. 12p. 1 Black and White Photograph, 2 Diagrams, 5 Graphs.

Therapeutic Approaches to Bone Diseases.

Autor: Rodan, Gideon A., Martin, T. John

Publikováno v: Science. 9/1/2000, Vol. 289 Issue 5484, p1508-1514. 7p. 3 Diagrams.