Zobrazeno 1 - 10
of 210
pro vyhledávání: '"J. M. Gillis"'
Autor:
Lin Xu, Joshua L. Pierce, Angelica Sanchez, Kenneth S. Chen, Abhay A. Shukla, Nicholas J. Fustino, Sarai H. Stuart, Aditya Bagrodia, Xue Xiao, Lei Guo, Mark D. Krailo, Furqan Shaikh, Deborah F. Billmire, Farzana Pashankar, Jessica Bestrashniy, J. Wolter Oosterhuis, Ad J. M. Gillis, Yang Xie, Lisa Teot, Jaume Mora, Jenny N. Poynter, Dinesh Rakheja, Leendert H. J. Looijenga, Bruce W. Draper, A. Lindsay Frazier, James F. Amatruda
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Germ cell tumors (GCTs) are neoplasms of the testis, ovary and extragonadal sites that occur in infants, children, adolescents and adults. Post-pubertal (type II) malignant GCTs may present as seminoma, non-seminoma or mixed histologies. In
Externí odkaz:
https://doaj.org/article/7de0ec00eddb4344af90c7a9512816da
Autor:
Silvia Schmidtova, Lambert C. J. Dorssers, Katarina Kalavska, Ad J. M. Gillis, J. Wolter Oosterhuis, Hans Stoop, Svetlana Miklikova, Zuzana Kozovska, Monika Burikova, Katarina Gercakova, Erika Durinikova, Michal Chovanec, Michal Mego, Lucia Kucerova, Leendert H. J. Looijenga
Publikováno v:
Cancer Cell International, Vol 20, Iss 1, Pp 1-16 (2020)
Abstract Background Cisplatin resistance of ovarian yolk sac tumors (oYST) is a clinical challenge due to dismal patient prognosis, even though the disease is extremely rare. We investigated potential association between cisplatin resistance and canc
Externí odkaz:
https://doaj.org/article/258316cd46dd400db76dfc03e396edbd
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-16 (2020)
Abstract Background Better biomarkers for assessing risk of relapse in stage I testicular germ cell tumor patients are needed, to complement classical histopathological variables. We aimed to assess the prognostic value of previously suggested biomar
Externí odkaz:
https://doaj.org/article/7a60a5d7d3f44e7b9116ea0a57f6e63f
Autor:
Dennis M. Timmerman, Thomas F. Eleveld, Ad J. M. Gillis, Carlijn C. Friedrichs, Sanne Hillenius, Tessa L. Remmers, Sruthi Sriram, Leendert H. J. Looijenga
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11774 (2021)
Germ cell tumors (GCTs) are considered to be highly curable; however, there are major differences in the outcomes related to histology and anatomical localization. GCTs originating from the testis are, overall, sensitive to platinum-based chemotherap
Externí odkaz:
https://doaj.org/article/e3ff7794ad124071bdac71a905542ee0
Autor:
Caroline C. C. Hulsker, Mariëtte E. G. Kranendonk, Thomas F. Eleveld, Ad J. M. Gillis, Cornelis P. van de Ven, Natasha K. A. van Eijkelenburg, Niels P. van der Kaaij, Alida F. W. van der Steeg, Leendert H. J. Looijenga
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9310 (2021)
Background and case: An adolescent male presented with a second mediastinal tumor 1.5 years after treatment of a proven malignant germ-cell tumor in that location. The differential diagnosis included a recurrent germ-cell tumor or a non-germ cell mal
Externí odkaz:
https://doaj.org/article/c00f6e268dda4c0ca252a0b2c8fab790
Autor:
Elske T Massolt, Layal Chaker, Theo J Visser, Ad J M Gillis, Lambert C J Dorssers, Carolien M Beukhof, Boen L R Kam, Gaston J Franssen, Giulia Brigante, Tessa M van Ginhoven, W Edward Visser, Leendert H J Looijenga, Robin P Peeters
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0194259 (2018)
Levothyroxine replacement treatment in hypothyroidism is unable to restore physiological thyroxine and triiodothyronine concentrations in serum and tissues completely. Normal serum thyroid stimulating hormone (TSH) concentrations reflect only pituita
Externí odkaz:
https://doaj.org/article/862dba42207647b4a33a87508098fdfa
Autor:
Zuzana Sycova-Mila, Leendert H. J. Looijenga, Michal Chovanec, Vera Miskovska, Maria Reckova, Daniela Svetlovska, Jana Obertova, Valentina De Angelis, Patrik Palacka, Michal Mego, Katarina Rejlekova, Jozef Mardiak, Katarina Kalavska, Ad J. M. Gillis, Daniel Pindak
Publikováno v:
European Urology Open Science, Vol 33, Iss, Pp 19-27 (2021)
European Urology Open Science
European Urology Open Science
Background Germ cell tumors represent highly curable disease even in metastatic stage. However, poor-risk patients with an unfavorable serum tumor marker (STM) decline after the first cycle of chemotherapy represent a subgroup with dismal prognosis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa68ffb871427c0cb6d2186b7958b89
http://www.sciencedirect.com/science/article/pii/S2666168321006716
http://www.sciencedirect.com/science/article/pii/S2666168321006716
Publikováno v:
First language
Auditory brainstem implantation (ABI) is a recent innovation in pediatric hearing restoration in children with a sensorineural hearing impairment. Only limited information is available on the spontaneous speech development of severe-to-profound conge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c269add4aee28afef8cd7ab7cd6d51c7
https://doi.org/10.1177/01427237211042216
https://doi.org/10.1177/01427237211042216
Autor:
Eleni Giannoulatou, Geoffrey J Maher, Zhihao Ding, Ad J M Gillis, Lambert C J Dorssers, Alexander Hoischen, Ewa Rajpert-De Meyts, WGS500 Consortium, Gilean McVean, Andrew O M Wilkie, Leendert H J Looijenga, Anne Goriely
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0178169 (2017)
Adult male germline stem cells (spermatogonia) proliferate by mitosis and, after puberty, generate spermatocytes that undertake meiosis to produce haploid spermatozoa. Germ cells are under evolutionary constraint to curtail mutations and maintain gen
Externí odkaz:
https://doaj.org/article/5ee5601fc0c34d3a8a8086765dae2fc3
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 2, p 258 (2019)
Current (high throughput omics-based) data support the model that human (malignant) germ cell tumors are not initiated by somatic mutations, but, instead through a defined locked epigenetic status, representative of their cell of origin. This elegant
Externí odkaz:
https://doaj.org/article/dbce08257d2f4177ae7d448b04ac1692