Zobrazeno 1 - 9
of 9
pro vyhledávání: '"J. M. Gibbins"'
Publikováno v:
Platelets, Vol 32, Iss 3, Pp 368-377 (2021)
Vascular complications resulting from atherosclerosis development are a major cause of death. Reactive oxygen species (ROS) are produced by platelets during activation, and have been demonstrated to positively regulate platelet activatory responses.
Externí odkaz:
https://doaj.org/article/3e247de1207a4a1e88103fc271d45ea6
Autor:
P. M. Ferreira, E. Bozbas, S. D. Tannetta, N. Alroqaiba, R. Zhou, J. T. B. Crawley, J. M. Gibbins, C. I. Jones, J. Ahnström, P. Yaqoob
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Abstract Platelet-derived extracellular vesicles (PDEVs) are the most abundant amongst all types of EVs in the circulation. However, the mechanisms leading to PDEVs release, their role in coagulation and phenotypic composition are poorly understood.
Externí odkaz:
https://doaj.org/article/eb77fbc2b64641a6ac78aac2d2517d27
Publikováno v:
Physics of life reviews.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ef874a36fb137d7c6c0a038bbab782c1
https://pubmed.ncbi.nlm.nih.gov/30477688
https://pubmed.ncbi.nlm.nih.gov/30477688
Autor:
L-M, Holbrook, G K, Sandhar, P, Sasikumar, M P, Schenk, A R, Stainer, K A, Sahli, G D, Flora, A B, Bicknell, J M, Gibbins
Publikováno v:
Journal of thrombosis and haemostasis : JTH. 16(2)
Essentials ERp72 is a thiol isomerase enzyme. ERp72 levels increase at the platelet surface during platelet activation. We generated a humanized monoclonal antibody which blocks ERp72 enzyme activity (anti-ERp72). Anti-ERp72 inhibits platelet functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9d0f4d9d7ce0a8f85c302e3374e8f1f3
https://pubmed.ncbi.nlm.nih.gov/29194946
https://pubmed.ncbi.nlm.nih.gov/29194946
Publikováno v:
Journal of Thrombosis and Haemostasis
Essentials peroxisome proliferator‐activated receptor γ (PPARγ) agonists inhibit platelet function.PPARγ agonists negatively regulate outside‐in signaling via integrin αIIbβ3.PPARγ agonists disrupt the interaction of Gα13 with integrin β3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f17e34dc696df691db37768a17acc6ac
https://pubmed.ncbi.nlm.nih.gov/27896950
https://pubmed.ncbi.nlm.nih.gov/27896950
Publikováno v:
Journal of Thrombosis and Haemostasis
Summary The role of platelets in hemostasis and thrombosis is dependent on a complex balance of activatory and inhibitory signaling pathways. Inhibitory signals released from the healthy vasculature suppress platelet activation in the absence of plat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0e75808078fa8e28233de1fba0c89828
https://pubmed.ncbi.nlm.nih.gov/26929147
https://pubmed.ncbi.nlm.nih.gov/26929147
Autor:
N E, Barrett, L, Holbrook, S, Jones, W J, Kaiser, L A, Moraes, R, Rana, T, Sage, R G, Stanley, K L, Tucker, B, Wright, J M, Gibbins
Publikováno v:
British journal of pharmacology. 154(5)
Platelets have long been recognized to be of central importance in haemostasis, but their participation in pathological conditions such as thrombosis, atherosclerosis and inflammation is now also well established. The platelet has therefore become a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5b9774bdb615c357c65f0be2484ca59c
https://pubmed.ncbi.nlm.nih.gov/18587441
https://pubmed.ncbi.nlm.nih.gov/18587441
Publikováno v:
Blood Coagulation & Fibrinolysis. 8:459
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b4fbc7493fdb8484990957e739a6139
https://doi.org/10.1097/00001721-199710000-00016
https://doi.org/10.1097/00001721-199710000-00016
Publikováno v:
The Biochemical journal. 228(3)
The rate of fatty acid synthesis in interscapular brown adipose tissue of female cold-adapted rats, as measured by the incorporation of 3H from 3H2O into tissue lipid, was decreased by about 70% after injection of noradrenaline. There was a similar d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b2d736bd8c007e2dcf959f048e061a
https://pubmed.ncbi.nlm.nih.gov/2862861
https://pubmed.ncbi.nlm.nih.gov/2862861