Zobrazeno 1 - 10
of 12
pro vyhledávání: '"J. M. Fukuto"'
Autor:
Gianmichele Massimo, Krishnaraj S. Rathod, Amrita Ahluwalia, Rayomand S. Khambata, C. Primus, Vikas Kapil, J. M. Fukuto, Daniel A. Jones
Publikováno v:
Pharmacological reviews. 72(3)
In contrast to nitric oxide, which has well established and important roles in the regulation of blood flow and thrombosis, neurotransmission, the normal functioning of the genitourinary system, and the inflammation response and host defense, its oxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::088a4de558cece61d84d0741f1789fcf
https://pubmed.ncbi.nlm.nih.gov/32576603
https://pubmed.ncbi.nlm.nih.gov/32576603
Publikováno v:
Biochemical and Biophysical Research Communications. 202:174-180
NG-hydroxy-L-arginine, an intermediate in the biosynthesis of nitric oxide (NO), has been found to be a uniquely potent competitive inhibitor of rat liver arginase. Among previously reported inhibitors of arginase and the eight arginine analogs teste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b47257aaaccdb20c944a13a6c8bdeaf
https://doi.org/10.1006/bbrc.1994.1909
https://doi.org/10.1006/bbrc.1994.1909
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(9)
Nitric oxide (NO) is both an endogenously generated species and the active species released from a variety of important drugs. Due to its endogenous generation and use as a therapeutic agent, the metabolism and fate of NO is of interest and concern.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::051e76db96241123aa72cee0abf71d03
https://pubmed.ncbi.nlm.nih.gov/10460799
https://pubmed.ncbi.nlm.nih.gov/10460799
Autor:
P S, Wong, J M, Fukuto
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(4)
Organic nitrate esters, such as glyceryl trinitrate and isosorbide dinitrate, are a class of compounds used to treat a variety of vascular ailments. Their effectiveness relies on their ability to be bioactivated to nitric oxide (NO) which, in turn, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::415cc11fa801f3c446451230ddba792f
https://pubmed.ncbi.nlm.nih.gov/10232931
https://pubmed.ncbi.nlm.nih.gov/10232931
Autor:
J M, Fukuto, D A, Wink
Publikováno v:
Metal ions in biological systems. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b58d56d6cd83364033bb29b6dd7a051b
https://pubmed.ncbi.nlm.nih.gov/10093936
https://pubmed.ncbi.nlm.nih.gov/10093936
Autor:
J M, Fukuto
Publikováno v:
Methods in enzymology. 268
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c0b23406cfa9ec4ad9f59379141afcb6
https://pubmed.ncbi.nlm.nih.gov/8782603
https://pubmed.ncbi.nlm.nih.gov/8782603
Publikováno v:
Journal of biochemistry. 117(4)
The role of thiols on the activation and/or stabilization of rat brain nitric oxide synthase (NOS) has been investigated. It was found that thiols are not necessary for stabilizing or protecting the protein during purification but are required during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4966dced961d6456a172c5c688c7edd9
https://pubmed.ncbi.nlm.nih.gov/7592560
https://pubmed.ncbi.nlm.nih.gov/7592560
Autor:
J M, Fukuto
Publikováno v:
Advances in pharmacology (San Diego, Calif.). 34
This discussion of NO chemistry has addressed only certain aspects that may be of biological relevance. It is not meant to be a comprehensive in-depth treatment of general NO chemistry. For more information regarding the chemistry of NO and related n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4e82a8dd54e462fb6ff8a40ad3301e4
https://pubmed.ncbi.nlm.nih.gov/8562429
https://pubmed.ncbi.nlm.nih.gov/8562429
Publikováno v:
The Journal of biological chemistry. 269(34)
The objective of this study was to elucidate the mechanism by which nitric oxide (NO) inhibits NO synthase. Previous studies revealed that NO inhibits unpurified preparations of NO synthase. In the present study, the mechanism by which NO inhibits pu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::62f84b94d5aaae9346b1a795025265fd
https://pubmed.ncbi.nlm.nih.gov/7520440
https://pubmed.ncbi.nlm.nih.gov/7520440
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 263(2)
Chemical oxidation of N-hydroxy-L-arginine (NOHA) and other N-hydroxyguanidines has been previously shown to generate either nitric oxide (NO) or nitroxyl (HNO), depending on the oxidative conditions. Because N-hydroxy-L-arginine has been demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ef86dfba89608a2b826ea7e5e5838b7
https://pubmed.ncbi.nlm.nih.gov/1331403
https://pubmed.ncbi.nlm.nih.gov/1331403