Zobrazeno 1 - 10
of 55
pro vyhledávání: '"J. M. Edwardson"'
Autor:
Wamberto Antonio Varanda, Ruth D. Murrell-Lagnado, J. M. Edwardson, Andrew P. Stewart, Ligia S. Antonio, Xing Jian Xu
Publikováno v:
British Journal of Pharmacology. 163:1069-1077
The P2X receptor family consists of seven subunit types - P2X1-P2X7. All but P2X6 are able to assemble as homotrimers. In addition, various subunit permutations have been reported to form heterotrimers. Evidence for heterotrimer formation includes co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48f0f7f6cec6ea0b8c05930b086e087c
https://doi.org/10.1111/j.1476-5381.2011.01303.x
https://doi.org/10.1111/j.1476-5381.2011.01303.x
Autor:
J. M. Edwardson, A. J. Morton
Publikováno v:
Journal of Neurochemistry. 76:166-172
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by motor, emotional and cognitive dysfunction. There is no treatment or cure for this disease, and after the onset of symptoms, usually in the fourth decade o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53f9ac4b84b5ea74b8af95e137d3ed6b
https://doi.org/10.1046/j.1471-4159.2001.00059.x
https://doi.org/10.1046/j.1471-4159.2001.00059.x
Publikováno v:
Journal of Neurochemistry. 70:1694-1703
Preexposure of SH-SY5Y cells to the muscarinic agonist carbachol caused a rapid desensitization of subsequent carbachol-stimulated intracellular Ca2+ responses and a slower decrease in the number of receptors at the plasma membrane. Desensitization (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e4cc9dbbac3974f14ea376d72069e5
https://doi.org/10.1046/j.1471-4159.1998.70041694.x
https://doi.org/10.1046/j.1471-4159.1998.70041694.x
Autor:
Robert M. Henderson, David T. F. Dryden, Shane S. Sturrock, Torunn Berge, J M Edwardson, Malcolm D. Walkinshaw, Paul Taylor, C. Atanasiu
Publikováno v:
Molecular Cell. 9:187-194
We have solved, by X-ray crystallography to a resolution of 1.8 A, the structure of a protein capable of mimicking approximately 20 base pairs of B-form DNA. This ocr protein, encoded by gene 0.3 of bacteriophage T7, mimics the size and shape of a be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::248f5d52cc1b29a388fdfc4e0ec59205
https://doi.org/10.1016/s1097-2765(02)00435-5
https://doi.org/10.1016/s1097-2765(02)00435-5
Publikováno v:
Journal of Neurochemistry. 73:1236-1245
NG108-15 cells express predominantly the M4 subtype of the muscarinic receptor for acetylcholine. Stimulation of these receptors by the agonist carbachol causes an inhibition of cellular adenylyl cyclase and a consequent fall in the intracellular cyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d42bfd6af700e36e2f11c0ef7b35b5
https://doi.org/10.1046/j.1471-4159.1999.0731236.x
https://doi.org/10.1046/j.1471-4159.1999.0731236.x
Autor:
J M Edwardson, A Hodel
Publikováno v:
Biochemical Journal. 350:637-643
Syncollin is a 13-kDa protein associated with the membranes of pancreatic zymogen granules. Here we determine the in situ localization of syncollin in pancreatic acinar cells from adult and neonatal rats, and study the targeting of green fluorescent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d575ca78954c61bc70d1f19fb9f811
https://doi.org/10.1042/bj3500637
https://doi.org/10.1042/bj3500637
Publikováno v:
Journal of Biological Chemistry
The molecular basis of exocytotic membrane fusion in the pancreatic acinar cell was investigated using an in vitro assay that measures both zymogen granule-plasma membrane fusion and granule-granule fusion. These two fusion events were differentially
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c712546e0944bf1252231dbe4911ba6
https://doi.org/10.1074/jbc.274.32.22871
https://doi.org/10.1074/jbc.274.32.22871
Publikováno v:
Microscopy Research and Technique. 44:368-377
The origin of contrast in atomic force microscopy (AFM) lies in the probe's response to forces between itself and the sample. These forces most commonly result from changes in height as the tip is scanned over the surface, but can also originate in p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd11458095424438b29da476b6d040a9
https://doi.org/10.1002/(sici)1097-0029(19990301)44:5<368::aid-jemt9>3.0.co
https://doi.org/10.1002/(sici)1097-0029(19990301)44:5<368::aid-jemt9>3.0.co
Publikováno v:
Biochemical Journal. 325:511-518
alpha-SNAP [soluble N-ethylmaleimide-sensitive fusion protein (NSF)-attachment protein] is required for fusion of transport vesicles with their target membrane. In this study, we have examined the membrane-binding properties of alpha-SNAP. We have fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb7b601f2856c155a4c88fb944a46578
https://doi.org/10.1042/bj3250511
https://doi.org/10.1042/bj3250511
Publikováno v:
British Journal of Pharmacology. 120:45-51
We have used somatostatin (SRIF) receptor subtype-selective ligands to determine some of the operational characteristics of somatostatin receptors in Neuro2A mouse neuroblastoma cells. The potent SRIF1-receptor selective ligand, BIM-23027, was able t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6192f0d39bb41f943fc354098d2c51a
https://doi.org/10.1038/sj.bjp.0700858
https://doi.org/10.1038/sj.bjp.0700858