Zobrazeno 1 - 10
of 98
pro vyhledávání: '"J. M. Dupuy"'
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 43:297-308
A [14C]-labelled form of (3-{[(Z)-5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethyl-ene)-2-oxo-1H-indol-1-yle]carbonylamino}propyl)trimethylammonium chloride, a potential cartilage-targeted antirheumatic drug, was required for pharmcokinetic studies. T
Autor:
Daniela Novick, Wolf H. Fridman, Thierry Dorval, Pierre Pouillart, S. Wolf, Eric Tartour, N. Haicheur, Sylvie Negrier, P. H. M. De Mulder, T. Guillot, J. M. Dupuy, Bernard Escudier
Publikováno v:
Clinical and Experimental Immunology, 28-37
STARTPAGE=28;ENDPAGE=37;ISSN=0009-9104;TITLE=Clinical and Experimental Immunology
Clinical and Experimental Immunology, pp. 28-37
STARTPAGE=28;ENDPAGE=37;ISSN=0009-9104;TITLE=Clinical and Experimental Immunology
Clinical and Experimental Immunology, pp. 28-37
SUMMARYThis study shows that subcutaneous administration of increasing doses of IL-12, once a week, in 21 cancer patients increased the expression of cytokine genes (interferon-gamma (IFN-γ), tumour necrosis factor-alpha (TNF-α), IP-10, MIG, IL-10,
Autor:
Jean-Claude Maurizis, Maryse Rapp, J. M. Dupuy, A. Veyre, C. Cussac-Buchdhal, Jean-Claude Madelmont, Eric Debiton, Emmanuelle Mounetou
Publikováno v:
British Journal of Cancer
The exposure of cells to O6-benzyl-N2-acetylguanosine (BNAG) and several guanine derivatives is known to reduce the activity of O6-alkylguanine-DNA alkyltransferase (MGMT) and to enhance the sensitivity of Mer+ (methyl enzyme repair positive) tumour
Autor:
Jean-Claude Maurizis, Annie Veyre, Jean-Claude Madelmont, René C.-Gaudreault, J. M. Dupuy, El-mostafa Azim
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 39:559-566
Carbonation of CH 3 MgI with 14 CO 2 led to sodium [1- 14 C] acetate: 1 which was successively brominated and esterifed with diazomethane to give rise to methyl 2-bromo-[-1- 14 C] acetate: 3, the reduction of which with H 3 Al gave 2-bromo-[-1- 14 C]
Autor:
Pierre Labarre, Ph. Chollet, A. Veyre, J. P. Baudry, J. C. Madelmont, C. Fontanon, J. M. Dupuy, D. Godenèche, A. Tisserant, C. Cussac
Publikováno v:
Drug Investigation. 7:234-243
The pharmacokinetics of perrimustine and cystemustine, 2 novel 2-chloroethylnitrosoureas (CENUs), were investigated in patients with various cancer diseases. The unique protocol followed in this study consisted of a 15-minute intravenous (IV) perfusi
Autor:
J. M. Dupuy, Annie Veyre, Jean-Claude Madelmont, Maryse Rapp, Jean-Claude Maurizis, Pierre Labarre, J. M. Gillardin, Françis Lepage
Publikováno v:
Xenobiotica. 23:1335-1343
1. The disposition of stiripentol labelled with 14C and 3H on two positions has been studied in the pregnant and non-pregnant female rat after p.o. administration of a 200 mg/kg dose. 2. For both labelled species radioactivity was eliminated mainly i
Autor:
Jean-Claude Madelmont, Maryse Rapp, Annie Veyre, Jean-Claude Maurizis, J. M. Dupuy, Pierre Labarre, Françis Lepage
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 31:961-966
4,4-dimethyl-1-(3-4-methylenedioxyphenyl)-1-pentene-3-ol or stiripentol was labelled by 14C and 3H. 14C labelling was performed on the carbone 1 of the pentene group via a four steps procedure after the carbonatation. The radiochemical yield calculat
Autor:
J. M. Dupuy, Annie Veyre, J. Sauzieres, Maryse Rapp, Jean-Claude Maurizis, Pierre Labarre, C. Cussac, J. L. Chabard, D. Godeneche, Jean-Claude Madelmont, J. P. Baudry
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 31:793-800
O6 Benzyl N acetyl guanosine a new inhibitor of O6 Alkyl Guanine transferase (O6AGT) was labelled by 14C and 13C on the benzyl methylen group in order to realize a pharmacokinetic study on nude mice grafted with human tumors. The labelling yield calc
Publikováno v:
European Journal of Immunogenetics. 18:405-410
Using H-2 recombinant congenic strains of mice, genetic analysis of resistance to murine hepatitis virus type 3 (MHV3)-induced paralysis was performed. It appeared that both H-2K and H-2D, two class I gene regions of the mouse major histocompatibilit
Autor:
Jean-Claude Maurizis, P. Demerseman, J. M. Meyniel, C. Nicolas, J. M. Dupuy, H. Garrigue, H. Sentenac-Roumanou, Et A. Veyre, Jean-Claude Madelmont
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 28:1385-1392
The two compounds were labelled by 14C on the hydroxyimino methyl group substituted on the 2 positions of the pyridinium ring. The convenient pyridinium lithiated intermediates were formylated with N-methyl 14C-formanilide. The hydroxyimino methyl gr