Zobrazeno 1 - 10
of 32
pro vyhledávání: '"J. M. Derocq"'
Autor:
P. Dousset, Xavier Dumont, Mourad Kaghad, P. Lelong, B. Pességué, David Shire, R Legoux, J.-M. Derocq, F.K. Jansen, H. Vidal, C. Carillon, B.J.P. Bourrié
Publikováno v:
Gene. 93:183-188
To assess the biological activity and pharmacokinetic properties of nonglycosylated ricin A-chain (RA), we have obtained the polypeptide following expression of a synthetic 842-bp RA gene in Escherichia coli. Expression of the gene was carried out us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3659a5a6dddaae7d767970e0c80ff850
https://doi.org/10.1016/0378-1119(90)90223-e
https://doi.org/10.1016/0378-1119(90)90223-e
Autor:
J. Lupker, Xavier Dumont, P. Liauzun, Pascual Ferrara, Jean-Claude Guillemot, Brigitte Miloux, Gérard Loison, Pierre Casellas, P. Leplatois, J.-M. Derocq, Adrian Minty, C. Minty, Mourad Kaghad, Pascale Chalon, D. Shire, C. Labit, Daniel Caput
Publikováno v:
Nature. 362:248-250
The discovery of new cytokines normally relies on a prior knowledge of at least one of their biological effects, which is used as a criterion either for the purification of the protein or for the isolation of the complementary DNA by expression cloni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25cec18024b1539bcca1ee8132a62010
https://doi.org/10.1038/362248a0
https://doi.org/10.1038/362248a0
Publikováno v:
The Journal of biological chemistry. 275(21)
The function of the peripheral cannabinoid receptor (CB2), which is mainly expressed on hematopoietic cells, remains an enigma. In an attempt to decipher its role, we used Affymetrix DNA chips to investigate the gene expression profile of the promyel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d220d8d809ad61f1c797f37cc77a4663
https://pubmed.ncbi.nlm.nih.gov/10821843
https://pubmed.ncbi.nlm.nih.gov/10821843
Autor:
M, Rinaldi-Carmona, F, Barth, J, Millan, J M, Derocq, P, Casellas, C, Congy, D, Oustric, M, Sarran, M, Bouaboula, B, Calandra, M, Portier, D, Shire, J C, Brelière, G L, Le Fur
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 284(2)
Based on both binding and functional data, this study introduces SR 144528 as the first, highly potent, selective and orally active antagonist for the CB2 receptor. This compound which displays subnanomolar affinity (Ki = 0.6 nM) for both the rat spl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3f9dfbf2ae524ef4096bf4a940b14ee8
https://pubmed.ncbi.nlm.nih.gov/9454810
https://pubmed.ncbi.nlm.nih.gov/9454810
Publikováno v:
Thrombosis and haemostasis. 75(2)
Endotoxin (LPS) and interleukin-1 beta (IL-1 beta) increased in a dose-dependent manner the expression of tissue factor, an ubiquitous membrane-anchored glycoprotein that initiates blood coagulation at the surface of human umbilical vein endothelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c3dc87b8fdbec50e92ef916f00b84fdd
https://pubmed.ncbi.nlm.nih.gov/8815590
https://pubmed.ncbi.nlm.nih.gov/8815590
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 272(1)
In previous studies, the authors demonstrated that the new sigma ligand, cis-N-cyclohexyl-N-ethyl-3-(3-chloro-4-cyclohexyl-phenyl) propen-2-ylamine hydrochloride (SR 31747), elicited a suppressive effect on immune responses through the sigma receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f5efcc939752736611bef67b81db74f0
https://pubmed.ncbi.nlm.nih.gov/7815336
https://pubmed.ncbi.nlm.nih.gov/7815336
Publikováno v:
The Journal of biological chemistry. 267(18)
Vacuole formation around the Golgi and immunotoxin enhancement induced by low doses of the ionophore monensin were inhibited by 50% human plasma (final concentration), whereas the lysosomal pH increase remained unaffected. Immunotoxin enhancement by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5bf489d8f946c0b63bd1423474832bb5
https://pubmed.ncbi.nlm.nih.gov/1618762
https://pubmed.ncbi.nlm.nih.gov/1618762
Publikováno v:
The Journal of Immunology. 141:2837-2843
The in vitro killing of the human CEM cell line was studied by using ricin A-chain immunotoxins constructed with either the whole IgG or the Fab and F(ab')2 fragments of the same T101 (anti-CD5) antibody. In the presence of ammonium chloride as an ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d03b6396c9bde125b68f5e49f9076bb4
https://doi.org/10.4049/jimmunol.141.8.2837
https://doi.org/10.4049/jimmunol.141.8.2837
Publikováno v:
Blood. 72(4)
To maximize T-lymphocyte killing with anti-pan-T-lymphocyte immunotoxin (IT), prepared by linking ricin A-chain to monoclonal antibody (MoAb) T101 (T101-RTA IT), we have established the nature and the extent of parameters that influence the sensitivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::32287bf78c6d3c380e9e0f2c3ebb40e3
https://pubmed.ncbi.nlm.nih.gov/3262384
https://pubmed.ncbi.nlm.nih.gov/3262384
Autor:
G, Laurent, D, Maraninchi, E, Gluckman, J P, Vernant, J M, Derocq, M H, Gaspard, B, Rio, M, Michalet, J, Reiffers, F, Dreyfus
Publikováno v:
Bone marrow transplantation. 4(4)
Thirty-eight patients with haematological malignancies were treated with bone marrow transplantation using histocompatible immunotoxin T cell-depleted marrow siblings. All patients received conventional postgraft immunosuppression (methotrexate and/o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b5e54a895401b7ce6191f3adaa5c02e2
https://pubmed.ncbi.nlm.nih.gov/2789084
https://pubmed.ncbi.nlm.nih.gov/2789084