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Akademický článek

Antigenic mapping of human low density lipoprotein with monoclonal antibodies

Autor: N J Tikkanen, R Dargar, B Pfleger, B Gonen, J M Davie, G Schonfeld

Publikováno v: Journal of Lipid Research, Vol 23, Iss 7, Pp 1032-1038 (1982)

Monoclonal anti-LDL antibodies were produced in a mouse spleen-myeloma system and purified by affinity chromatography on insolubilized low density lipoprotein (LDL). Five antibodies with different specificities could be distinguished by their immunor

Externí odkaz: https://doaj.org/article/a1da69c5ff524ad8bfccfe6ea20d95d5

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Akademický článek

Limited proteolysis selectively destroys epitopes on apolipoprotein B in low density lipoproteins.

Autor: K S Hahm, M J Tikkanen, R Dargar, T G Cole, J M Davie, G Schonfeld

Publikováno v: Journal of Lipid Research, Vol 24, Iss 7, Pp 877-885 (1983)

Apolipoprotein B (apoB), the major apoprotein in human low density lipoprotein (LDL), is a large protein and complex immunogen, against which seven monoclonal IgG antibodies have been produced in our laboratory. These antibodies were used to define a

Externí odkaz: https://doaj.org/article/87cd169b59734dbeb360ab43048ff736

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Idiotope structure and genetic diversity in anti-streptococcal group A carbohydrate antibodies

Autor: N J Phillips, J M Davie

Publikováno v: The Journal of Immunology. 145:915-924

Three cross-reactive idiotopes(Id), termed IdX, IdI-1, and Id5, that are present on free L chains from murine anti-group A streptococcal carbohydrate antibodies have been mapped; these Id distinguish between products of three homologous V kappa genes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2483204ab3b98d645ea8bfee92442952
https://doi.org/10.4049/jimmunol.145.3.915

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Analysis of anti-streptococcal group A carbohydrate idiotope levels in sera: correlation of magnitude of expression with idiotope position and VK haplotype

Autor: N S Greenspan, R J Fulton, J M Davie

Publikováno v: The Journal of Immunology. 137:228-233

We have employed monoclonal anti-idiotopes to map the corresponding idiotopes on the variable domain of a prototype antibody specific for streptococcal group A carbohydrate (GAC). Idiotope variability, as assessed by direct and competitive binding as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::83e6c91ab9244cbe5252e87a954a5bf1
https://doi.org/10.4049/jimmunol.137.1.228

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Roles of apolipoproteins B and E in the cellular binding of very low density lipoproteins

Autor: Elaine S. Krul, Matti J. Tikkanen, J. M. Davie, Gustav Schonfeld, Thomas G. Cole

Publikováno v: Journal of Clinical Investigation. 75:361-369

Apoproteins B and E both interact with cellular low density lipoprotein (LDL) apolipoprotein B and E (apo B,E)-receptors, and very low density lipoproteins (VLDL) contain both apo B and apo E. Our aim was to study the relative importance of apo B and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3c21de15db99317db37f3fb927e168
https://doi.org/10.1172/jci111708

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Analysis of idiotope variability as a function of distance from the binding site for anti-streptococcal group A carbohydrate antibodies

Autor: N S Greenspan, J M Davie

Publikováno v: The Journal of Immunology. 135:1914-1921

We have extended our analysis of rat monoclonal anti-idiotopes (anti-Id) specific for previously mapped binding site-associated (distal) and less-or nonbinding site-associated (proximal) idiotopes on a murine monoclonal anti-streptococcal group A car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8543e306dad7ddbbe053596a944568cd
https://doi.org/10.4049/jimmunol.135.3.1914

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Analysis of the Diversity of Murine Antibodies to Dextran B1355: N-Terminal Amino Acid Sequences of Heavy Chains from Serum Antibody

Autor: J. Schilling, D. Hansburg, J. M. Davie, L. Hood

Publikováno v: The Journal of Immunology. 123:384-388

The N-terminal amino acid sequences of two γ and two µ chains from normally induced serum antibodies to dextran in BALB/c mice are presented. These heavy chains are derived from antibodies with three distinguishable idiotypes. These variable region

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de0f325b831990c00f393f83a5771a53
https://doi.org/10.4049/jimmunol.123.1.384

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Influence of the immunoglobulin heavy chain locus on expression of the VK1GAC light chain

Autor: R J Fulton, J M Davie

Publikováno v: The Journal of Immunology. 133:465-470

The VK1GAC light chain represents the dominant V kappa structure employed in the antibody response of A/J mice to streptococcal group A carbohydrate ( GAC ). Two anti-idiotypic antisera, anti- Id5 and anti- Id20 , with specificity for the VK1GAC ligh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c851d09b4e6253d04ca50df4687dc32e
https://doi.org/10.4049/jimmunol.133.1.465

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Clonal nature of the immune response to phosphorylcholine (PC). V. Cross-idiotypic specificity among heavy chains of murine anti-PC antibodies and PC-binding myeloma proteins

Autor: J M Davie, J L Claflin

Publikováno v: The Journal of Experimental Medicine

Seven mouse myeloma proteins with specificity for phosphorylcholine (PC) were found to share a common antigenic determinant. This group of proteins contained members which differed in genetic origin, heavy chain class, kappa-chain subgroup, individua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa72091cfee017aa0d5ee6b305e76a1
https://doi.org/10.1084/jem.141.5.1073

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