Zobrazeno 1 - 10
of 20
pro vyhledávání: '"J. M. Cherrington"'
Autor:
H M R, Pattzi, S, Pitale, M, Alpizar, C, Bennett, A M, O'Farrell, J, Li, J M, Cherrington, H-P, Guler, Robert L, Topkis
Publikováno v:
Diabetes, Obesity and Metabolism. 12:348-355
Aim: To determine efficacy and tolerability of dutogliptin, a dipeptidyl peptidase 4 (DPP4) inhibitor, in patients with type 2 diabetes mellitus. Methods: This was a 12-week, multicentre, randomized, double-blind, placebo-controlled trial in 423 pati
Publikováno v:
Antiviral Chemistry and Chemotherapy. 7:203-208
Cidofovir 1-[(S)-3-hydroxy-2-(phosphonomethoxy) propyl] cytosine, HPMPC] is an acyclic cytosine nucleotide analogue with potent in-vitro and in-vivo activity against a broad spectrum of herpesviruses including human cytomegalovirus (HCMV). Cidofovir
Autor:
S. H. Krawczyk, J. M. Cherrington, N. Bischofberger, S. J. W. Allen, A. S. Mulato, L. R. McGee
Publikováno v:
Antiviral Chemistry and Chemotherapy. 7:37-45
Nucleotide dimers and monomers were shown to inhibit human immunodeficiency virus type 1 (HIV) RNase H activity. Several effective inhibitors were identified and placed into three general groups based on biochemical characterization of their inhibiti
Publikováno v:
Antiviral Chemistry and Chemotherapy. 6:217-221
The inhibitory effects of the diphosphates of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and its analogues on HIV reverse transcriptase and human DNA polymerases α, β, and γ have been studied. The analogues investigated are the diphosphates of 9-(
Publikováno v:
Journal of Virology. 65:887-896
Repression of human cytomegalovirus alpha (immediate-early) gene expression is under the control of the viral ie2 gene. Here we show that ie2 negatively regulates gene expression directed by the strong cytomegalovirus enhancer via a specific 15-bp ta
Autor:
T. W. Littlejohn, G. Garcia-Soria, Sherwyn Schwartz, G. M. Argoud, X. Li, H.-P. Guler, J. M. Cherrington, Craig A. Bennett, G. Gonzalez-Galvez, A. M. O’Farrell, M. Gerstman
Publikováno v:
Diabetes, obesitymetabolism. 10(4)
Aim To determine the efficacy and tolerability of PHX1149, a novel dipeptidyl peptidase-4 (DPP4) inhibitor, in patients with type 2 diabetes. Methods This is a multicentre, randomized, double-blind, placebo-controlled, 4-week study in patients with t
Autor:
J G, Christensen, R E, Schreck, E, Chan, X, Wang, C, Yang, L, Liu, J, Cui, L, Sun, J, Wei, J M, Cherrington, D B, Mendel
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(12)
The epidermal growth factor receptor (EGFR) and HER-2 tyrosine kinases have been implicated in the development, progression, and severity of several human cancers and are attractive targets for therapeutic intervention. SU11925 was developed as a sma
Autor:
D B, Mendel, R E, Schreck, D C, West, G, Li, L M, Strawn, S S, Tanciongco, S, Vasile, L K, Shawver, J M, Cherrington
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 6(12)
SU5416, a selective inhibitor of the tyrosine kinase activity of the vascular endothelial growth factor (VEGF) receptor Flk-1/KDR, is currently in Phase III clinical trials for the treatment of advanced malignancies. In cellular assays, SU5416 inhibi
Autor:
D B, Mendel, A D, Laird, B D, Smolich, R A, Blake, C, Liang, A L, Hannah, R M, Shaheen, L M, Ellis, S, Weitman, L K, Shawver, J M, Cherrington
Publikováno v:
Anti-cancer drug design. 15(1)
Angiogenesis, or the sprouting of new blood vessels, is a central process in the growth of solid tumors. For many cancers, the extent of vascularization of a tumor is a negative prognostic indicator signifying aggressive disease and increased potenti
Publikováno v:
Advances in cancer research. 79
Angiogenesis, the sprouting of new blood vessels, plays a role in diverse disease states including cancer, diabetic retinopathy, age-related macular degeneration, rheumatoid arthritis, psoriasis, atherosclerosis, and restenosis. With regard to cancer