Výsledky vyhledávání - "J. M. B. Wilson"

Isolation of various forms of sterol β-d-glucoside from the seed of Cycas circinalis: neurotoxicity and implications for ALS-parkinsonism dementia complex

Autor: Bryce A. Pasqualotto, Christopher A. Shaw, J. M. B. Wilson, Lidong Liu, Yu Tian Wang, Raymond J. Andersen, Iraj Khabazian, U‐K. Craig, Seung U. Kim, David E. Williams, Jaswinder S. Bains, A. Nagai, J. Cheung, Steven L. Pelech

Publikováno v: Journal of Neurochemistry. 82:516-528

The factors responsible for ALS-parkinsonism dementia complex (ALS-PDC), the unique neurological disorder of Guam, remain unresolved, but identification of causal factors could lead to clues for related neurodegenerative disorders elsewhere. Earlier

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f489e558b7765aa704dac8c24749f9ee
https://doi.org/10.1046/j.1471-4159.2002.00976.x

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Reverse Engineering Neurological Disease

Autor: J. M. B. Wilson, Christopher A. Shaw, Iraj Khabazian

Publikováno v: Unifying Themes in Complex Systems IV ISBN: 9783540738480

The key problem for preventing the onset of the age-dependent neurological diseases (Alzheimer’s, Parkinson’s, and ALS) lies in knowing what factor(s) triggers the cascade of events leading to neuron cell death. Similarly, halting such cascades b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0166150d9c48c809e34458d2986fbdc
https://doi.org/10.1007/978-3-540-73849-7_11

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Chronic exposure to dietary sterol glucosides is neurotoxic to motor neurons and induces an ALS-PDC phenotype

Autor: R. C. Tabata, Christopher A. Shaw, Neil R. Cashman, P. Ly, D. Kwok, P. Zwiegers, J. M. Van Kampen, J. M. B. Wilson

Publikováno v: Neuromolecular medicine. 10(1)

Epidemiological studies of the Guamanian variants of amyotrophic lateral sclerosis (ALS) and parkinsonism, amyotrophic lateral sclerosis-parkinsonism dementia complex (ALS-PDC), have shown a positive correlation between consumption of washed cycad se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3332ee34b01db90eff6fa855e38622d4
https://pubmed.ncbi.nlm.nih.gov/18196479

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Magnetic resonance microscopy and immunohistochemistry of the CNS of the mutant SOD murine model of ALS reveals widespread neural deficits

Autor: Stephen J. Blackband, Christopher A. Shaw, Michael S. Petrik, Xiaoyang Shan, R. C. Tabata, Charles Krieger, J. M. B. Wilson, Samuel C. Grant

Publikováno v: Neuromolecular medicine. 9(3)

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that primarily affects motor neurons and descending motor tracts of the CNS. We have evaluated the CNS of a murine model of familial ALS based on the over-expression of mutant human s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b4a19fccbd878a5e412126e77c8d54
https://pubmed.ncbi.nlm.nih.gov/17914180

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Late appearance of glutamate transporter defects in a murine model of ALS-parkinsonism dementia complex

Autor: J M B Wilson, C A Shaw

Publikováno v: Neurochemistry international. 50(7-8)

Excitotoxicity has been widely hypothesized to play a major role in various neurodegenerative diseases. We have used a mouse model of ALS-parkinsonism dementia complex (ALS-PDC) of the Western Pacific to explore this hypothesis. Mice fed washed cycad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b665e04a7485ff0c6640c94b91978df
https://pubmed.ncbi.nlm.nih.gov/17095122

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