Zobrazeno 1 - 10
of 1 896
pro vyhledávání: '"J. Lyon"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Tuberculosis (TB) remains a major underdiagnosed public health threat worldwide, being responsible for more than 10 million cases and one million deaths annually. TB diagnosis has become more rapid with the development and adoption of molecular tests
Externí odkaz:
https://doaj.org/article/62b9ebc22df244a89fa663b4de20b0c1
Autor:
Zhen Huang, Lili Zhang, Christopher J. Lyon, Bo Ning, Brady M. Youngquist, Alex Niu, Brandon J. Beddingfield, Nicholas J. Maness, Nakhle S. Saba, Chen-Zhong Li, Chad J. Roy, Tony Y. Hu
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 629-638 (2022)
Mounting evidence indicates that SARS-CoV-2 can infect multiple systemic tissues, but few studies have evaluated SARS-CoV-2 RNA dynamics in multiple specimen types due to their reduced accessibility and diminished performance of RT-qPCR with non-resp
Externí odkaz:
https://doaj.org/article/37331d055e52443da112f8ee0fb7a565
Autor:
Qian Hu, Shu Zhang, Yue Yang, Jia-Qi Yao, Wen-Fu Tang, Christopher J. Lyon, Tony Ye Hu, Mei-Hua Wan
Publikováno v:
Military Medical Research, Vol 9, Iss 1, Pp 1-21 (2022)
Abstract Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common life-threatening lung diseases associated with acute and severe inflammation. Both have high mortality rates, and despite decades of research on clinical ALI/A
Externí odkaz:
https://doaj.org/article/5802c62ada2b4154bd763ea5efaab9d3
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
The close association between bacteria and insect hosts has played an indispensable role in insect diversity and ecology. Thus, continued characterization of such insect-associated-microbial communities is imperative, especially those of saprophagous
Externí odkaz:
https://doaj.org/article/0baec0e74255496caf00f5905391b264
Autor:
Amy Louise Ball, Carol E Jolly, Mark G Lennon, Jonathan J Lyon, Ana Alfirevic, Amy E Chadwick
Publikováno v:
eLife, Vol 12 (2023)
Background: Evidence supports an important link between mitochondrial DNA (mtDNA) variation and adverse drug reactions such as idiosyncratic drug-induced liver injury (iDILI). Here, we describe the generation of HepG2-derived transmitochondrial cybri
Externí odkaz:
https://doaj.org/article/cac0c9cc70c841ffb77c6bdfa52724f5
Autor:
Alynna J. Lyon
It is no secret that the US variously pulls away from the United Nations and embraces it as a significant venue for policy initiatives. But what explains this dramatic inconsistency? What is the logic of US multilateralism? Alynna Lyon explores the p
Publikováno v:
Materials Today Bio, Vol 18, Iss , Pp 100538- (2023)
Exosomes are membrane-defined extracellular vesicles (EVs) approximately 40–160 nm in diameter that are found in all body fluids including blood, urine, and saliva. They act as important vehicles for intercellular communication between both loca
Externí odkaz:
https://doaj.org/article/49b7e1b6c0c448c2b2addb50a66d7f67
Autor:
Daniel Danis, Julius O. B. Jacobsen, Parithi Balachandran, Qihui Zhu, Feyza Yilmaz, Justin Reese, Matthias Haimel, Gholson J. Lyon, Ingo Helbig, Christopher J. Mungall, Christine R. Beck, Charles Lee, Damian Smedley, Peter N. Robinson
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-13 (2022)
Abstract Structural variants (SVs) are implicated in the etiology of Mendelian diseases but have been systematically underascertained owing to sequencing technology limitations. Long-read sequencing enables comprehensive detection of SVs, but approac
Externí odkaz:
https://doaj.org/article/fe605196548d4f368b64f3d69399235e
Publikováno v:
BME Frontiers, Vol 4 (2023)
Extensive effort has been devoted to the discovery, development, and validation of biomarkers for early disease diagnosis and prognosis as well as rapid evaluation of the response to therapeutic interventions. Genomic and transcriptomic profiling are
Externí odkaz:
https://doaj.org/article/6f4f541d7ecd4594bf0c7ea1b5705d9d
Autor:
Katie A. O’Brien, Ben D. McNally, Alice P. Sowton, Antonio Murgia, James Armitage, Luke W. Thomas, Fynn N. Krause, Lucas A. Maddalena, Ian Francis, Stefan Kavanagh, Dominic P. Williams, Margaret Ashcroft, Julian L. Griffin, Jonathan J. Lyon, Andrew J. Murray
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-20 (2021)
Abstract Background Tissue hypoxia is a key feature of several endemic hepatic diseases, including alcoholic and non-alcoholic fatty liver disease, and organ failure. Hypoxia imposes a severe metabolic challenge on the liver, potentially disrupting i
Externí odkaz:
https://doaj.org/article/e6fa613deccb4bec8cc1aae51e72dedf