Impaired Mitochondrial Biogenesis in Adipose Tissue in Acquired Obesity

Autor: Maheswary Muniandy, Anu Suomalainen, Miina Ollikainen, Katriina Vuolteenaho, Jana Buzkova, Sini Heinonen, Risto Kaksonen, Aila Rissanen, Khadeeja Ismail, Eeva Moilanen, Kirsi H. Pietiläinen, Antti Hakkarainen, Nina Lundbom, J. Lundbom, Jaakko Kaprio

Publikováno v: Diabetes. 64:3135-3145

Low mitochondrial number and activity have been suggested as underlying factors in obesity, type 2 diabetes, and metabolic syndrome. However, the stage at which mitochondrial dysfunction manifests in adipose tissue after the onset of obesity remains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a524d6645c6ead5b38414eff392e99e
https://doi.org/10.2337/db14-1937

Characterising metabolically healthy obesity in weight-discordant monozygotic twins

Autor: Sampsa Hautaniemi, Gema Frühbeck, Nina Lundbom, Sini Heinonen, Kirsi H. Pietiläinen, Antti Hakkarainen, Lilli Saarinen, Katriina Vuolteenaho, Eeva Moilanen, P. Pajunen, Matej Orešič, Jaakko Kaprio, Anu Suomalainen, Amaia Rodríguez, Tuulia Hyötyläinen, Aila Rissanen, Jussi Naukkarinen, J. Lundbom

Publikováno v: Naukkarinen, J, Heinonen, S, Hakkarainen, A, Lundbom, J, Vuolteenaho, K, Saarinen, L, Hautaniemi, S, Rodriguez, A, Frühbeck, G, Pajunen, P, Hyötyläinen, T, Orešič, M, Moilanen, E, Suomalainen, A, Lundbom, N, Kaprio, J, Rissanen, A & Pietiläinen, K H 2014, ' Characterising metabolically healthy obesity in weight-discordant monozygotic twins ', Diabetologia, vol. 57, no. 1, pp. 167-176 . https://doi.org/10.1007/s00125-013-3066-y
Diabetologia; Vol 57
Diabetologia

Aims/hypothesis: Not all obese individuals display the metabolic disturbances commonly associated with excess fat accumulation. Mechanisms maintaining this ‘metabolically healthy obesity’ (MHO) are as yet unknown. We aimed to study different fat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf614c51bc439080c43518936816feb
https://doi.org/10.1007/s00125-013-3066-y

Deep subcutaneous adipose tissue is more saturated than superficial subcutaneous adipose tissue

Autor: Marja-Riitta Taskinen, J. Lundbom, Nina Lundbom, Antti Hakkarainen

Publikováno v: International Journal of Obesity. 37:620-622

Upper body abdominal subcutaneous adipose tissue (SAT) can be divided into deep SAT (DSAT) and superficial SAT (SSAT) depots. Studies on adipose tissue fatty acid (FA) composition have made no distinction between these two depots. The aim of this stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e47e7930451028eb4df9242d2e28d3
https://doi.org/10.1038/ijo.2012.72

CB(1) blockade-induced weight loss over 48 weeks decreases liver fat in proportion to weight loss in humans

Autor: Nina Lundbom, Aila Rissanen, Anna Kotronen, R. Bergholm, M. Urjansson, Antti Hakkarainen, Hannele Yki-Järvinen, Alexandre Pereira Delgado e Santos, Ksenia Sevastianova, Mirja Tiikkainen, J. Lundbom

Publikováno v: International journal of obesity (2005). 37(5)

Studies in mice have suggested that endocannabinoid blockade using the cannabinoid receptor type 1 (CB1) blocker rimonabant prevents obesity-induced hepatic steatosis.To determine effects of rimonabant on liver fat in humans, we measured liver fat co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b04bf7342d2cf61c9b5f8d96911a477
https://pubmed.ncbi.nlm.nih.gov/22828945

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