Zobrazeno 1 - 10
of 243
pro vyhledávání: '"J. Lumb"'
Autor:
D. Stephenson, A. Perry, M. R. Appleby, D. Lee, J. Davison, A. Johnston, A. L. Jones, A. Nelson, S. J. Bourke, M. F. Thomas, A. De Soyza, J. L. Lordan, J. Lumb, A. E. Robb, J. R. Samuel, K. E. Walton, J. D. Perry
Publikováno v:
BMC Pulmonary Medicine, Vol 19, Iss 1, Pp 1-12 (2019)
Abstract Background RGM medium is an agar-based, selective culture medium designed for the isolation of nontuberculous mycobacteria (NTM) from the sputum of patients with cystic fibrosis (CF). We evaluated RGM medium for the detection of NTM in patie
Externí odkaz:
https://doaj.org/article/5d1baad6a49e46db891e2a4cb5f5848f
Autor:
Aaron A. Thompson, Michael B. Harbut, Pei-Pei Kung, Nathan K. Karpowich, Jeffrey D. Branson, Joanna C. Grant, Deborah Hagan, Heather A. Pascual, Guoyun Bai, Reza Beheshti Zavareh, Heather R. Coate, Bernard C. Collins, Marjorie Côte, Christine F. Gelin, Kelly L. Damm-Ganamet, Hadi Gholami, Adam R. Huff, Luis Limon, Kevin J. Lumb, Puiying A. Mak, Kohki M. Nakafuku, Edmund V. Price, Amy Y. Shih, Mandana Tootoonchi, Nadeem A. Vellore, Jocelyn Wang, Na Wei, Jeannie Ziff, Scott B. Berger, James P. Edwards, Agnès Gardet, Siquan Sun, Jennifer E. Towne, Jennifer D. Venable, Zhicai Shi, Hariharan Venkatesan, Marie-Laure Rives, Sujata Sharma, Brock T. Shireman, Samantha J. Allen
Publikováno v:
Proceedings of the National Academy of Sciences. 120
NKG2D (natural-killer group 2, member D) is a homodimeric transmembrane receptor that plays an important role in NK, γδ + , and CD8 + T cell-mediated immune responses to environmental stressors such as viral or bacterial infections and oxidative st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4d48b50bde14ca39eb944d361970a99
https://doi.org/10.1073/pnas.2216342120
https://doi.org/10.1073/pnas.2216342120
Publikováno v:
The Journal of Laryngology & Otology. 136:486-491
ObjectiveOtitis externa accounts for 1.1–1.3 per cent of patient presentations in primary care and 25 per cent of urgent referrals to ENT. This study aimed to explore otitis externa clinical decision-making at the primary-secondary care interface,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e07abb7b5c2134ed90e7c535599486
https://doi.org/10.1017/s0022215121003649
https://doi.org/10.1017/s0022215121003649
Autor:
TB Fretwell, J Lumb, S Shakir, Hilary Tedd, K Cattermole, John M. Davison, P McCallion, A Royston, Benjamin Messer, HJ Carlin, A De Soyza, RE Sobala
Publikováno v:
Advances in the management of TB and NTM infections.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bae1f540fbcc88eec0ff0ffe78c5b51a
https://doi.org/10.1136/thorax-2021-btsabstracts.151
https://doi.org/10.1136/thorax-2021-btsabstracts.151
Autor:
Samantha J, Allen, Kevin J, Lumb
Publikováno v:
Advances in protein chemistry and structural biology. 121
Protein-protein interactions are central to biology and provide opportunities to modulate disease with small-molecule or protein therapeutics. Recent developments in the understanding of the tractability of protein-protein interactions are discussed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::18dc9e25d067ab3e3bf0576f4d7b5f9f
https://pubmed.ncbi.nlm.nih.gov/32312425
https://pubmed.ncbi.nlm.nih.gov/32312425
Publikováno v:
The Journal of Physiology. 596:6009-6019
KEY POINTS Evidence obtained at whole animal, organ-system, and cellular and molecular levels suggests that afferent volume feedback is critical for the establishment of adequate ventilation at birth. As a result of the irreversible nature of the vag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ac8071f8d760fe704d0ccea101e5dd8
https://doi.org/10.1113/jp275682
https://doi.org/10.1113/jp275682
Autor:
Adam B Weinglass, Nicholas B Hastings, Bradley S Sherborne, Jennifer M. Johnston, Andrew D Howard, Maria Webb, Steven L. Colletti, Clemens Vonrhein, Kevin J. Lumb, Srivanya Tummala, Frank K Brown, Jennifer Hadix, Hubert Josien, Stephen M. Soisson, Guo Yan, Harry R. Chobanian, John Wang, Michael W. Miller, Brande Thomas-Fowlkes, Dawn L. Hall, Jeffrey D. Hermes, Thu Ho, Barbara Pio, Payal R. Sheth, Sujata Sharma, Maria Kornienko, Samantha J Allen, Sangita B. Patel, Jerry Di Salvo, Sarah Souza, Gérard Bricogne, Christopher W Plummer, Jun Lu, Noel Byrne
Publikováno v:
Nature Structural & Molecular Biology. 24:570-577
Clinical studies indicate that partial agonists of the G-protein-coupled, free fatty acid receptor 1 GPR40 enhance glucose-dependent insulin secretion and represent a potential mechanism for the treatment of type 2 diabetes mellitus. Full allosteric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db4bc0224021f59b552cc8f44381dfe9
https://doi.org/10.1038/nsmb.3417
https://doi.org/10.1038/nsmb.3417
Autor:
Kevin J. Lumb, Samantha J Allen
Publikováno v:
Advances in Protein Chemistry and Structural Biology ISBN: 9780128168462
Protein-protein interactions are central to biology and provide opportunities to modulate disease with small-molecule or protein therapeutics. Recent developments in the understanding of the tractability of protein-protein interactions are discussed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecdecf790171ac6068f25f58c9972cd1
https://doi.org/10.1016/bs.apcsb.2019.12.006
https://doi.org/10.1016/bs.apcsb.2019.12.006
Autor:
Nathaniel L. Elsen, Zangwei Xu, Peter J. Dandliker, Peter Saradjian, Keith W. Rickert, Berengere Sauvagnat, Nadya Smotrov, Dawn L. Hall, Elliott B. Nickbarg, Yiping Chen, Sujata Sharma, Kevin J. Lumb, Maria Kornienko, Noel Byrne, Chad Chamberlin, Christine Andrews, Samantha J Allen, Ilona Kariv, Jennifer M. Shipman, Patrick J. Curran, Kevin G. Coleman, Beutel Bruce A, Rachael E. Ford, Victoria Kutilek, Andrew Hashke, Rafael Fernandez, Tianxiao Sun, Matthew Richards, Ryan Boinay
Publikováno v:
SLAS Discovery. 21:608-619
The primary objective of early drug discovery is to associate druggable target space with a desired phenotype. The inability to efficiently associate these often leads to failure early in the drug discovery process. In this proof-of-concept study, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321009edd98ca17a57d26928e293e5e3
https://doi.org/10.1177/1087057116637353
https://doi.org/10.1177/1087057116637353
Autor:
A De Soyza, KE Walton, John D. Perry, Dominic Stephenson, J Davison, Amanda Jones, Appleby, J Lumb, Audrey Perry, Andrew Nelson
Publikováno v:
Atypical bugs, atypical challenges.
Introduction and objectives Non-tuberculous mycobacteria (NTM) are significant respiratory pathogens that have been estimated to affect around 9% of individuals with non-cystic fibrosis bronchiectasis (BR). Detection of NTM is achieved by conventiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63c661d721b8d0ef20f7a8402d8e3534
https://doi.org/10.1136/thorax-2018-212555.31
https://doi.org/10.1136/thorax-2018-212555.31