Zobrazeno 1 - 10
of 21
pro vyhledávání: '"J. Luis Morales"'
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11348 (2010)
Murine models of allergic asthma have been used to understand the mechanisms of development and pathology in this disease. In addition, knockout mice have contributed significantly to our understanding of the roles of specific molecules and cytokines
Externí odkaz:
https://doaj.org/article/a342d68b4bc94c43bfe0f98bbb454a4a
Publikováno v:
Journal of Allergy and Clinical Immunology. 137:1197-1205
Background Mast cells are indispensable for LPS-induced septic hypothermia, in which TNF-α plays an essential role to initiate septic responses. ITK and BTK regulate mast cell responses to allergens, but their roles in mast cell responses in LPS-ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d10bab55d32383f93e9872ffe2912d
https://doi.org/10.1016/j.jaci.2015.08.056
https://doi.org/10.1016/j.jaci.2015.08.056
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 45:1074-1082
Tec family kinases play critical roles in the activation of immune cells. In particular, Itk is important for the activation of T cells via the T cell Receptor (TcR), however, molecules that cooperate with Itk to activate downstream targets remain li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629e71423a015b16d3580dd441150d69
https://doi.org/10.1016/j.biocel.2013.02.011
https://doi.org/10.1016/j.biocel.2013.02.011
Autor:
Laurie F. Mottram, Blake R. Peterson, Archana Iyer, J. Luis Morales, Danny Bruce, Tomoaki Shirao, Mankit Law, Qian Qi, Jason C. Mercer, Avery August, Hiroyuki Yamazaki
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 42:337-345
Store-operated calcium channels are plasma membrane Ca2+ channels that are activated by depletion of intracellular Ca2+ stores, resulting in an increase in intracellular Ca2+ concentration, which is maintained for prolonged periods in some cell types
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31fa047823887a6ad461e6e1bc08b46
https://doi.org/10.1016/j.biocel.2009.11.019
https://doi.org/10.1016/j.biocel.2009.11.019
Publikováno v:
Biochemistry. 47:8445-8455
In addition to orchestrating an adaptive metabolic response to xenobiotic compounds, the aryl hydrocarbon receptor (AHR) also plays a necessary role in the normal physiology of mice. The AHR is activated by a structurally diverse group of chemicals r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd73e04fcad5cd0c487edead43e54a07
https://doi.org/10.1021/bi800712f
https://doi.org/10.1021/bi800712f
Publikováno v:
Critical Reviews™ in Eukaryotic Gene Expression. 18:207-250
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that controls the expression of a diverse set of genes. The toxicity of the potent AhR ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin is almost exclusively mediated through th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e33112adc70ce95ba0264f45af86e17
https://doi.org/10.1615/critreveukargeneexpr.v18.i3.20
https://doi.org/10.1615/critreveukargeneexpr.v18.i3.20
Autor:
J. Luis Morales, Gary H. Perdew
Publikováno v:
Biochemistry. 46:610-621
The regulation of the aryl hydrocarbon receptor (AhR) protein levels has been an area of keen interest, given its important role in mediating the cellular adaptation and toxic response to several environmental pollutants. The carboxyl terminus of hsc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435e9ec029477e15b15e1eab2dacfa6f
https://doi.org/10.1021/bi062165b
https://doi.org/10.1021/bi062165b
Autor:
J. Luis Morales, Amie Wood, Sonia Mohinta, Avery August, Jihong Song, Jonathan Pabon, Chavez Carter, Weishan Huang, Gang Ning, Arun Kannan, Mankit Law, Ah Reum Jeong, Yongchan Lee
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 195(2)
Mast cells play critical roles in allergic responses. Calcium signaling controls the function of these cells, and a role for actin in regulating calcium influx into cells has been suggested. We have previously identified the actin reorganizing protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eecdfdce9e849c5e179f774706342df
https://pubmed.ncbi.nlm.nih.gov/26056254
https://pubmed.ncbi.nlm.nih.gov/26056254
Autor:
Avery August, Laurie F. Mottram, Blake R. Peterson, Mankit Law, Archana Iyer, J. Luis Morales
Mast cells play a critical role in the development of the allergic response. Upon activation by allergens and IgE via the high affinity receptor for IgE (FcɛRI), these cells release histamine and other functional mediators that initiate and propagat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd87fe4d8e08d34bacb31687500f5974
https://europepmc.org/articles/PMC3143500/
https://europepmc.org/articles/PMC3143500/
Autor:
Archana Iyer, Folake Ojo, Weishan Huang, Elizabeth G. Wills, Gang Ning, J. Luis Morales, Avery August, Joel D. Baines
Mast cells are critical effector cells in the pathophysiology of allergic asthma and other IgE-mediated diseases. The Tec family of tyrosine kinases Itk and Btk serve as critical signal amplifiers downstream of antigen receptors. Although both kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ae5148b81b4a89b553fc09ea279ceb
https://europepmc.org/articles/PMC3059023/
https://europepmc.org/articles/PMC3059023/