Inhibition of Receptor-Interacting Protein Kinase 1 in Chronic Plaque Psoriasis: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study

Autor: Valerie J. Ludbrook, David C. Budd, Katie Thorn, Debra Tompson, Bartholomew J. Votta, Lucy Walker, Amy Lee, Xin Chen, Amanda Peppercorn, Wei Jing Loo

Publikováno v: Dermatology and Therapy, Vol 14, Iss 2, Pp 489-504 (2024)

Abstract Introduction Receptor-interacting protein kinase 1 (RIPK1), a key mediator of inflammation through necroptosis and proinflammatory cytokine production, may play a role in the pathogenesis of immune-mediated inflammatory diseases such as chro

Externí odkaz: https://doaj.org/article/1b2c7392c4ac4a949714b6dc004b1758

Adaptive study design to assess effect of TRPV4 inhibition in patients with chronic cough

Autor: Valerie J. Ludbrook, Kate E. Hanrott, James L. Kreindler, Joanna E. Marks-Konczalik, Nick P. Bird, Debbie A. Hewens, Misba Beerahee, David J. Behm, Alyn Morice, Lorcan McGarvey, Sean M. Parker, Surinder S. Birring, Jaclyn Smith

Publikováno v: ERJ Open Research, Vol 7, Iss 3 (2021)

Objective Airway sensory nerves involved in the cough reflex are activated by adenosine triphosphate (ATP) agonism of P2X purinoceptor 3 (P2X3) receptors. Transient receptor potential vanilloid 4 (TRPV4) channel activation causes ATP release from air

Externí odkaz: https://doaj.org/article/8898a21c0e9847d39d530aa3f6cd63d4

International comparison of cosmetic outcomes of breast conserving surgery and radiation therapy for women with ductal carcinoma in situ of the breast

Autor: Peter Graham, Mohamed Akra, Emma Link, Boon Chua, Timothy J. Whelan, G. Bryant, Jennifer Harvey, J Ludbrook, Ivo A. Olivotto, Ian Campbell, Guenther Gruber, Kash Purohit, O. McArdle, Geoff P. Delaney, A. Helen Westenberg, Joseph Martin, John H. Maduro, Ian H. Kunkler, Claire Phillips, Verity Ahern, C. Kirkove

Publikováno v: Olivotto, I A, Link, E, Phillips, C, Whelan, T J, Bryant, G, Kunkler, I, Westenberg, H, Purohit, K, Ahern, V, H. Graham, P, Akra, M, McArdle, O, Ludbrook, J J, Harvey, J A, Maduro, J H, Kirkove, C, Gruber, G, Martin, J D, Campbell, I D & Delaney, G P & Chua, B H 2019, ' International comparison of cosmetic outcomes of breast conserving surgery and radiation therapy for women with ductal carcinoma in situ of the breast ', Radiotherapy and Oncology . https://doi.org/10.1016/j.radonc.2019.07.024
Radiotherapy and Oncology, 142, 180-185. ELSEVIER IRELAND LTD

Purpose: To assess the cosmetic impact of breast conserving surgery (BCS), whole breast irradiation (WBI) fractionation and tumour bed boost (TBB) use in a phase III trial for women with ductal carcinoma in situ (DCIS) of the breast. Materials and me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b666fc5cf437a6af83fe7a21bb4447
https://doi.org/10.1016/j.radonc.2019.07.024

Implementation of the Australian Computer-Assisted Theragnostics (AusCAT) network for radiation oncology data extraction, reporting and distributed learning

Autor: Andrew Miller, Noel J Aherne, Lois Holloway, Martin G Carolan, Stuart Greenham, Shalini K Vinod, Eric Hau, Matthew Field, Andre Dekker, Joerg Lehmann, Jonathan R Sykes, David Thwaites, J Ludbrook, Geoff P. Delaney, Angela Rezo, Jothybasu Selvaraj

Publikováno v: Journal of Medical Imaging and Radiation Oncology, 65(5), 627-636. Wiley-Blackwell

Introduction There is significant potential to analyse and model routinely collected data for radiotherapy patients to provide evidence to support clinical decisions, particularly where clinical trials evidence is limited or non-existent. However, in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f77d5d21515fb249537024db94087602
https://pubmed.ncbi.nlm.nih.gov/34331748

Fostering a culture of research within a clinical radiation oncology department

Autor: Mary-Claire Hanlon, Karen Jovanovic, Peter B. Greer, J Ludbrook, Jarad Martin

Publikováno v: Journal of Medical Imaging and Radiation Oncology. 62:102-108

Introduction Support and investment in increasing a research-active culture in clinical practice needs to be translated at the department and hospital levels as well as regional, state and national levels. We aimed to improve the research culture of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00845d294df559cb23dacef6b9adef2f
https://doi.org/10.1111/1754-9485.12662