Zobrazeno 1 - 10
of 139
pro vyhledávání: '"J. Louise Jones"'
Autor:
Shayin V. Gibson, Elena Tomas Bort, Lucía Rodríguez-Fernández, Michael D. Allen, Jennifer J. Gomm, Iain Goulding, Ulrich auf dem Keller, Andrea Agnoletto, Cathrin Brisken, Barrie Peck, Angus J. Cameron, John F. Marshall, J. Louise Jones, Edward P. Carter, Richard P. Grose
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer. Virtually all women with DCIS are treated, despite evidence suggesting up to half would remain with stable, non-threatening, disease. Overtreatment thus p
Externí odkaz:
https://doaj.org/article/121dd275e1f548edb93a722fbf4391bf
Autor:
Mary-Kate Hayward, Michael D. Allen, Jennifer J. Gomm, Iain Goulding, Clare L. Thompson, Martin M. Knight, John F. Marshall, J. Louise Jones
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract Women with ductal carcinoma in situ (DCIS) have an increased risk of progression to invasive breast cancer. Although not all women with DCIS will progress to invasion, all are treated as such, emphasising the need to identify prognostic biom
Externí odkaz:
https://doaj.org/article/df3865fd8d414597839305295fcc1d88
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12613 (2023)
Our understanding of the molecular mechanisms underlying cancer development and evolution have evolved rapidly over recent years, and the variation from one patient to another is now widely recognized. Consequently, one-size-fits-all approaches to th
Externí odkaz:
https://doaj.org/article/275820e1459f43a88e940a7a5dbad0c8
Autor:
Lorenzo Massimi, Tamara Suaris, Charlotte K. Hagen, Marco Endrizzi, Peter R. T. Munro, Glafkos Havariyoun, P. M. Sam Hawker, Bennie Smit, Alberto Astolfo, Oliver J. Larkin, Richard M. Waltham, Zoheb Shah, Stephen W. Duffy, Rachel L. Nelan, Anthony Peel, J. Louise Jones, Ian G. Haig, David Bate, Alessandro Olivo
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Margins of wide local excisions in breast conserving surgery are tested through histology, which can delay results by days and lead to second operations. Detection of margin involvement intraoperatively would allow the removal of additional
Externí odkaz:
https://doaj.org/article/747a630515f14ffe9ee31490fe6ea21c
Autor:
Mary-Kate Hayward, J. Louise Jones, Allison Hall, Lorraine King, Alastair J. Ironside, Andrew C. Nelson, E. Shelley Hwang, Valerie M. Weaver
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 4063-4070 (2020)
Abnormalities in cell nuclear morphology are a hallmark of cancer. Histological assessment of cell nuclear morphology is frequently used by pathologists to grade ductal carcinoma in situ (DCIS). Objective methods that allow standardization and reprod
Externí odkaz:
https://doaj.org/article/f3b1d2da06f149639ba5551c838d7dec
Autor:
Abbie E. Fearon, Edward P. Carter, Natasha S. Clayton, Edmund H. Wilkes, Ann-Marie Baker, Ekaterina Kapitonova, Bakhouche A. Bakhouche, Yasmine Tanner, Jun Wang, Emanuela Gadaleta, Claude Chelala, Kate M. Moore, John F. Marshall, Juliette Chupin, Peter Schmid, J. Louise Jones, Michelle Lockley, Pedro R. Cutillas, Richard P. Grose
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2469-2481 (2018)
Summary: Development of resistance causes failure of drugs targeting receptor tyrosine kinase (RTK) networks and represents a critical challenge for precision medicine. Here, we show that PHLDA1 downregulation is critical to acquisition and maintenan
Externí odkaz:
https://doaj.org/article/7789669635aa4bc0b1737b37a1d0838a
Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors
Autor:
Emily A. Saunderson, Peter Stepper, Jennifer J. Gomm, Lily Hoa, Adrienne Morgan, Michael D. Allen, J. Louise Jones, John G. Gribben, Tomasz P. Jurkowski, Gabriella Ficz
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
“Although aberrant promoter DNA hypermethylation is a hallmark of cancer, it is not clear whether it is sufficient to drive transformation. Here, the authors use CRISPR-dCas9 to perform hit-and-run epigenetic editing, which prevents senescence entr
Externí odkaz:
https://doaj.org/article/cc5d45d93ae34cfa90c771738264e95a
Publikováno v:
Breast Cancer Research, Vol 19, Iss 1, Pp 1-10 (2017)
Abstract Background 3D modelling fulfils a critical role in research, allowing for complex cell behaviour and interactions to be studied in physiomimetic conditions. With tissue banks becoming established for a number of cancers, researchers now have
Externí odkaz:
https://doaj.org/article/0bead3cd38e0441dbd249ad35dcb267e
Autor:
David S. Guttery, Rachael A. Hancox, Kellie T. Mulligan, Simon Hughes, Sinead M. Lambe, J. Howard Pringle, Rosemary A. Walker, J. Louise Jones, Jacqueline A. Shaw
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-1 (2018)
After the publication of this work [1] an error was noticed in Fig. 6 (b). In the MCF-7/Vector columns, the same image was used accidentally for the 0 h and 24 h time points. Both images were taken from the 0 h time point.
Externí odkaz:
https://doaj.org/article/a5d0dee01c1b48d2a333bc0f2dbc059d
Autor:
Shayin V. Gibson, Reza M. Roozitalab, Michael D. Allen, J. Louise Jones, Edward P. Carter, Richard P. Grose
Publikováno v:
Trends in Cancer. 9:326-338