Zobrazeno 1 - 10
of 62
pro vyhledávání: '"J. Leigh Leasure"'
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 15 (2021)
The recognition of novel objects is a common cognitive test for rodents, but current paradigms have limitations, such as low sensitivity, possible odor confounds and stress due to being performed outside of the homecage. We have developed a paradigm
Externí odkaz:
https://doaj.org/article/5df6c91a16f144b3bbd0b1c28095ef3a
Publikováno v:
Brain Sciences, Vol 11, Iss 9, p 1250 (2021)
Binge alcohol consumption and alcohol use disorders (AUD) are prevalent, and there is comorbidity with depression and anxiety. Potential underlying mechanisms include neurophysiological, genetic, and metabolic changes resulting from alcohol exposure.
Externí odkaz:
https://doaj.org/article/3346aa6019c3408f9bbb224f038a59fe
Autor:
Emma C. Perez, Shaefali P. Rodgers, Taeko Inoue, Steen E. Pedersen, J. Leigh Leasure, M. Waleed Gaber
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 12 (2018)
Although an effective treatment for pediatric brain tumors, cranial radiation therapy (CRT) damages surrounding healthy tissue, thereby disrupting brain development. Animal models of pediatric CRT have primarily relied on visual tasks to assess cogni
Externí odkaz:
https://doaj.org/article/c288d300b2ce4202a79deb86a5e81eaf
Publikováno v:
Neural Plasticity, Vol 2016 (2016)
Cranial radiotherapy (CRT) increases survival in pediatric brain-tumor patients but can cause deleterious effects. This study evaluates the acute and long-term impact of CRT delivered during childhood/adolescence on the brain and body using a rodent
Externí odkaz:
https://doaj.org/article/dd21094a9e9c4046a127abbec71a5981
Publikováno v:
Brain Sciences, Vol 7, Iss 10, p 139 (2017)
The female brain appears selectively vulnerable to the neurotoxic effects of alcohol, but the reasons for this are unclear. One possibility is an exaggerated neuroimmune response in the female brain, such that alcohol increases microglia number and r
Externí odkaz:
https://doaj.org/article/38f73a4f155d4401b12e45d5644f792d
Publikováno v:
Neural Plasticity, Vol 2013 (2013)
Brain cancer is a common type of childhood malignancy, and radiotherapy (RT) is a mainstay of treatment. RT is effective for tumor eradication, and survival rates are high. However, RT damages the brain and disrupts ongoing developmental processes, r
Externí odkaz:
https://doaj.org/article/522c1627639547dbbc646452869230f1
Autor:
Craig E. Henderson, Laian Z. Najjar, Chelsie M. Young, J. Leigh Leasure, Clayton Neighbors, Melissa L. Gasser, Kristen P. Lindgren
Publikováno v:
Psychology of Addictive Behaviors. 37:285-293
Recent research has revealed positive associations between alcohol use and physical activity. However, findings from these studies have been inconsistent, and longitudinal designs have been underutilized. Therefore, the present study examined longitu
Publikováno v:
Journal of Studies on Alcohol and Drugs. 84:137-146
Akademický článek
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Publikováno v:
Brain Plasticity
Historically, most alcohol neurotoxicity studies were conducted in young adult males and focused on chronic intake. There has been a shift towards studying the effects of alcohol on the adolescent brain, due to alcohol consumption during this formati