Zobrazeno 1 - 10
of 955
pro vyhledávání: '"J. LeClerc"'
Publikováno v:
Wellcome Open Research, Vol 9 (2024)
Background Efforts to estimate the global burden of antimicrobial resistance (AMR) have highlighted gaps in existing surveillance systems. Data gathered from hospital networks globally by pharmaceutical industries to monitor antibiotic efficacy in di
Externí odkaz:
https://doaj.org/article/7decdf8f4b6f465ca087ee190b4fef2c
Publikováno v:
PLoS Medicine, Vol 21, Iss 7, p e1004433 (2024)
BackgroundLong-term care facilities (LTCFs) are hotspots for pathogen transmission. Infection control interventions are essential, but the high density and heterogeneity of interindividual contacts within LTCF may hinder their efficacy. Here, we expl
Externí odkaz:
https://doaj.org/article/2ba01e5175144e079011111cb8af176a
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 6, p e1012227 (2024)
Small populations (e.g., hospitals, schools or workplaces) are characterised by high contact heterogeneity and stochasticity affecting pathogen transmission dynamics. Empirical individual contact data provide unprecedented information to characterize
Externí odkaz:
https://doaj.org/article/2d272bed4d764bb391395391adefd9ee
Autor:
Quentin J. Leclerc, Emily S. Nightingale, Sam Abbott, CMMID COVID-19 Working Group, Thibaut Jombart
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract The National Health Service (NHS) Pathways triage system collates data on enquiries to 111 and 999 services in England. Since the 18th of March 2020, these data have been made publically available for potential COVID-19 symptoms self-reporte
Externí odkaz:
https://doaj.org/article/2831dc14c35c4c80859086a8e7f8ff64
Autor:
Gwenan M Knight, Rebecca E Glover, C Finn McQuaid, Ioana D Olaru, Karin Gallandat, Quentin J Leclerc, Naomi M Fuller, Sam J Willcocks, Rumina Hasan, Esther van Kleef, Clare IR Chandler
Publikováno v:
eLife, Vol 10 (2021)
Before the coronavirus 2019 (COVID-19) pandemic began, antimicrobial resistance (AMR) was among the top priorities for global public health. Already a complex challenge, AMR now needs to be addressed in a changing healthcare landscape. Here, we analy
Externí odkaz:
https://doaj.org/article/a0c482ba9d674074885c1a67e80168d1
Autor:
Akira Endo, Centre for the Mathematical Modelling of Infectious Diseases COVID-19 Working Group, Quentin J. Leclerc, Gwenan M. Knight, Graham F. Medley, Katherine E. Atkins, Sebastian Funk, Adam J. Kucharski
Publikováno v:
Wellcome Open Research, Vol 5 (2020)
Introduction: Contact tracing has the potential to control outbreaks without the need for stringent physical distancing policies, e.g. civil lockdowns. Unlike forward contact tracing, backward contact tracing identifies the source of newly detected c
Externí odkaz:
https://doaj.org/article/1d536a71aed0438f886d5e878dd980ef
Autor:
Andrew Clark, PhD, Mark Jit, ProfPhD, Charlotte Warren-Gash, PhD, Bruce Guthrie, ProfPhD, Harry H X Wang, PhD, Stewart W Mercer, ProfPhD, Colin Sanderson, ProfPhD, Martin McKee, ProfDSc, Christopher Troeger, MPH, Kanyin L Ong, PhD, Francesco Checchi, ProfPhD, Pablo Perel, ProfPhD, Sarah Joseph, PhD, Hamish P Gibbs, MSc, Amitava Banerjee, DPhil, Rosalind M Eggo, PhD, Emily S Nightingale, Kathleen O'Reilly, Thibaut Jombart, W John Edmunds, Alicia Rosello, Fiona Yueqian Sun, Katherine E Atkins, Nikos I Bosse, Samuel Clifford, Timothy W Russell, Arminder K Deol, Yang Liu, Simon R Procter, Quentin J Leclerc, Graham Medley, Gwen Knight, James D Munday, Adam J Kucharski, Carl A B Pearson, Petra Klepac, Kiesha Prem, Rein M G J Houben, Akira Endo, Stefan Flasche, Nicholas G Davies, Charlie Diamond, Kevin van Zandvoort, Sebastian Funk, Megan Auzenbergs, Eleanor M Rees, Damien C Tully, Jon C Emery, Billy J Quilty, Sam Abbott, Ch Julian Villabona-Arenas, Stéphane Hué, Joel Hellewell, Amy Gimma, Christopher I Jarvis
Publikováno v:
The Lancet Global Health, Vol 8, Iss 8, Pp e1003-e1017 (2020)
Summary: Background: The risk of severe COVID-19 if an individual becomes infected is known to be higher in older individuals and those with underlying health conditions. Understanding the number of individuals at increased risk of severe COVID-19 an
Externí odkaz:
https://doaj.org/article/7cefbc9edc754cc1bf55134172b7efbe
Autor:
Quentin J. Leclerc, Naomi M. Fuller, Lisa E. Knight, CMMID COVID-19 Working Group, Sebastian Funk, Gwenan M. Knight
Publikováno v:
Wellcome Open Research, Vol 5 (2020)
Background: Concern about the health impact of novel coronavirus SARS-CoV-2 has resulted in widespread enforced reductions in people’s movement (“lockdowns”). However, there are increasing concerns about the severe economic and wider societal c
Externí odkaz:
https://doaj.org/article/d9ef9712d98746e481e960fa696a5024
Publikováno v:
Wellcome Open Research, Vol 4 (2020)
Background: Antibiotics are often prescribed empirically to treat infection syndromes before causative bacteria and their susceptibility to antibiotics are identified. Guidelines on empiric antibiotic prescribing are key to effective treatment of inf
Externí odkaz:
https://doaj.org/article/f6380eb524f34068a886b795f2f09ea0
Autor:
Julio C. Barredo, Theodore J. Lampidis, Guy J. Leclerc, Gilles M. Leclerc, Jianfeng Du, Jeffim N. Kuznetsov, Joanna DeSalvo
The ability to pair the regulation of metabolism and cellular energetics with oncogenes and tumor suppressor genes provides cancer cells with a growth and survival advantage over normal cells. We investigated the mechanism of cell death induced by 2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b11bc58bb06a7b0721f066cad99407c0
https://doi.org/10.1158/1541-7786.c.6541816
https://doi.org/10.1158/1541-7786.c.6541816
